OSCR

Estrogen deprivation exacerbates Alzheimer's disease pathology through neuronal CTSS signaling.

Overview

Authors: Renzhi Yang1,2, Lin Shao3, Fang Huang1,2, Ying He1,2, Meng Yuan1,2, Qilong Wu1,2, Sen Lin3, Kai Guo2, Hongsheng Zhang1,2
  1. Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Department of Neurobiology, School of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016 China
  2. Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400014 China
  3. Department of Neurology, Second Affiliated Hospital, Army Medical University, Chongqing, 400037 China
Institutions: The Affiliated Yongchuan Hospital of Chongqing Medical University (China); Chongqing Medical University (China); Army Medical University (China)
Journal: Journal of neuroinflammation, volume 23, issue 1, article 311
Dates: received 21 April 2026; accepted 13 July 2026; published online 11 September 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03970-5 · PMID 42728627 · PMCID PMC13570535 · OpenAlex W7212228751
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Statistics, Smoothing, state filtering, decompositions, fMRI & imaging
MeSH: Alzheimer Disease*, Cathepsins*, Estrogens*, Neurons*, Signal Transduction*, Amyloid beta-Peptides, Animals, Brain, Female, Humans, Mice, Mice, Transgenic, Ovariectomy (* major topic)
Topic: Menopause: Health Impacts and Treatments (Endocrinology, Diabetes and Metabolism, Medicine), according to OpenAlex
Funding: the Lingang Laboratory (LG-GG-202401-ADAD060100 and LG-GG-202401-ADA060200); National Natural Science Foundation of China (82271472); the Natural Science Foundation of Chongqing (CSTB2022NSCQ-LZX0033); the Science and Technology Research Program of Chongqing Municipal Education Commission (KJQN202200479); CQMU Program for Youth Innovation in Future Medicine (W0158)
Citations: not cited yet (Europe PMC); 68 references in the paper
Research resources: rabbit anti Bassoon RRID:AB_1860018, 1:10000 for WB) and mouse anti-GAPDH RRID:AB_2107436, rat anti-LAMP1 RRID:AB_2134500, rabbit anti-PU.1 RRID:AB_2186909, rabbit anti-β Tubulin RRID:AB_2210695, mouse anti-PSD-95 RRID:AB_2292909, RRID:AB_2534017, RRID:AB_2534102, RRID:AB_2534104, RRID:AB_2535729, RRID:AB_2536183, C-Terminal RRID:AB_258409, rabbit anti-β-Actin RRID:AB_2687938, RRID:AB_2722564, RRID:AB_2722565, rabbit anti-Synaptophysin RRID:AB_2766946, rabbit anti-α Tubulin RRID:AB_2863541, RRID:AB_2893137, rabbit anti-GFAP RRID:AB_305808, rat anti-CD68 RRID:AB_3100585, goat anti-IBA1 RRID:AB_3148646, rabbit anti-IBA1 RRID:AB_839504

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1186/s12974-026-03970-5.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 13 MeSH terms, 5 funders, 68 references, 22 RRIDs.

Cite

This paper

Yang, R., Shao, L., Huang, F., He, Y., Yuan, M., Wu, Q., Lin, S., Guo, K., & Zhang, H. (2026). Estrogen deprivation exacerbates Alzheimer's disease pathology through neuronal CTSS signaling. Journal of neuroinflammation, 23(1), 311. https://doi.org/10.1186/s12974-026-03970-5

BibTeX

@article{yang2026estrogen,
author = {Yang, Renzhi and Shao, Lin and Huang, Fang and He, Ying and Yuan, Meng and Wu, Qilong and Lin, Sen and Guo, Kai and Zhang, Hongsheng},
title = {{Estrogen deprivation exacerbates Alzheimer's disease pathology through neuronal CTSS signaling}},
journal = {Journal of neuroinflammation},
year = {2026},
month = sep,
volume = {23},
number = {1},
pages = {311},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03970-5},
url = {https://doi.org/10.1186/s12974-026-03970-5},
pmid = {42728627},
pmcid = {PMC13570535}
}

RIS

TY - JOUR
AU - Yang, Renzhi
AU - Shao, Lin
AU - Huang, Fang
AU - He, Ying
AU - Yuan, Meng
AU - Wu, Qilong
AU - Lin, Sen
AU - Guo, Kai
AU - Zhang, Hongsheng
TI - Estrogen deprivation exacerbates Alzheimer's disease pathology through neuronal CTSS signaling
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/09/11
VL - 23
IS - 1
SP - 311
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03970-5
UR - https://doi.org/10.1186/s12974-026-03970-5
LA - en
ER -

CSL-JSON

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