OSCR

Metabolic parameter variability, brain structure, perfusion, and cognition: a population-based study.

Overview

Authors: Xiaoshuai Li1, Xuejia Li2, Mengmeng Bai3, Ling Yang1, Jing Chen4, Jiacheng Fan5, Huijing Shi6, Rui Li1, Xiaoliang Liang5, Shun Zhang5, Pengfei Zhao1, Jing Li7, Han Lv1, Shuohua Chen8, Zhenghan Yang1, Zhenjian Yu5, Yuntao Wu8, Ying Hui9, Shouling Wu8, Zhenchang Wang1
  1. Department of Radiology, Beijing Friendship Hospital, Capital Medical University,Beijing, 100050 China
  2. Department of Radiology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital),Qingdao, Shandong Province 266001 China
  3. Hebei North University,Zhangjiakou, Hebei Province 075000 China
  4. Department of CT, Kailuan General Hospital,No. 57 Xinhua East Road, Tangshan, Hebei Province 063000 China
  5. Department of Psychiatry, Kailuan Mental Health Center, Jixiang Road, Hua Yuan Street, Lunan District, Tangshan, Hebei Province 063000 China
  6. Department of Rheumatology and Immunology, Kailuan General Hospital,No. 57 Xinhua East Road, Tangshan, Hebei Province 063000 China
  7. Beijing Tsinghua Changgung Hospital,Beijing, 102218 China
  8. Department of Cardiology, Kailuan General Hospital,No. 57 Xinhua East Road, Tangshan, Hebei Province 063000 China
  9. Department of MR, Kailuan General Hospital,No. 57 Xinhua East Road, Tangshan, Hebei Province 063000 China
Institutions: Capital Medical University (China); Qingdao Municipal Hospital (China); Hebei North University (China); Kailuan General Hospital (China); Beijing Tsinghua Chang Gung Hospital (China)
Journal: Alzheimer's research & therapy, volume 18, issue 1, article 160
Dates: received 8 January 2026; accepted 7 May 2026; published online 20 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s13195-026-02074-9 · PMID 42157314 · PMCID PMC13360039 · OpenAlex W7161740006
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: structural MRI / diffusion (modality), human (organism), Alzheimer's / dementia (population), stroke (population), cognitive (subfield)
Methods: Statistics, fMRI & imaging
Keywords: Metabolic parameter variability, Coefficient of variation, Cerebral blood flow, Brain volume, Cognitive function, Mediation analyses
MeSH: Brain*, Cerebrovascular Circulation*, Cognition*, Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies (* major topic)
Topic: Diet and metabolism studies (Physiology, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82202109); Beijing Natural Science Foundation (7232335); Beijing Scholar 2015 (2015-160); Beijing Key Clinical Discipline Funding (2021-135); Beijing Natural Science Foundation Youth Science Fund Key Project (JR25018)
Citations: not cited yet (Europe PMC); 55 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1186/s13195-026-02074-9.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 6 keywords, 10 MeSH terms, 5 funders, 55 references.

Cite

This paper

Li, X., Li, X., Bai, M., Yang, L., Chen, J., Fan, J., Shi, H., Li, R., Liang, X., Zhang, S., Zhao, P., Li, J., Lv, H., Chen, S., Yang, Z., Yu, Z., Wu, Y., Hui, Y., Wu, S., & Wang, Z. (2026). Metabolic parameter variability, brain structure, perfusion, and cognition: a population-based study. Alzheimer's research & therapy, 18(1), 160. https://doi.org/10.1186/s13195-026-02074-9

BibTeX

@article{li2026metabolic,
author = {Li, Xiaoshuai and Li, Xuejia and Bai, Mengmeng and Yang, Ling and Chen, Jing and Fan, Jiacheng and Shi, Huijing and Li, Rui and Liang, Xiaoliang and Zhang, Shun and Zhao, Pengfei and Li, Jing and Lv, Han and Chen, Shuohua and Yang, Zhenghan and Yu, Zhenjian and Wu, Yuntao and Hui, Ying and Wu, Shouling and Wang, Zhenchang},
title = {{Metabolic parameter variability, brain structure, perfusion, and cognition: a population-based study}},
journal = {Alzheimer's research \& therapy},
year = {2026},
month = may,
volume = {18},
number = {1},
pages = {160},
publisher = {BMC},
issn = {1758-9193},
doi = {10.1186/s13195-026-02074-9},
url = {https://doi.org/10.1186/s13195-026-02074-9},
pmid = {42157314},
pmcid = {PMC13360039}
}

RIS

TY - JOUR
AU - Li, Xiaoshuai
AU - Li, Xuejia
AU - Bai, Mengmeng
AU - Yang, Ling
AU - Chen, Jing
AU - Fan, Jiacheng
AU - Shi, Huijing
AU - Li, Rui
AU - Liang, Xiaoliang
AU - Zhang, Shun
AU - Zhao, Pengfei
AU - Li, Jing
AU - Lv, Han
AU - Chen, Shuohua
AU - Yang, Zhenghan
AU - Yu, Zhenjian
AU - Wu, Yuntao
AU - Hui, Ying
AU - Wu, Shouling
AU - Wang, Zhenchang
TI - Metabolic parameter variability, brain structure, perfusion, and cognition: a population-based study
T2 - Alzheimer's research & therapy
J2 - Alzheimers Res Ther
PY - 2026
DA - 2026/05/20
VL - 18
IS - 1
SP - 160
SN - 1758-9193
PB - BMC
DO - 10.1186/s13195-026-02074-9
UR - https://doi.org/10.1186/s13195-026-02074-9
LA - en
ER -

CSL-JSON

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