Silencing arachidonate 15-lipoxygenase alleviates hypoxia-induced cognitive impairment through the mediation of phospholipase A2 group IVC-LPC18:0 to suppress ferroptosis.
Overview
- School of Pharmaceutical Sciences, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Metabonomics & Medical NMR, Wenzhou Medical University, Wenzhou, 325035 China
- College of Pharmacy, Chonnam National University, Gwangju, 61186 Republic of Korea
- Research and Experiment Center, Innovation Academy of Testing Technology, Wenzhou Medical University, Wenzhou, 325035 China
Abstract
Hypoxic injury is a major contributor to cognitive impairment (CI), but the lipid metabolic mechanisms linking hypoxia (HYP) to hippocampal ferroptosis remain understood. This study investigated whether the arachidonate 15-lipoxygenase-cytosoli
Supplementary Information: The online version contains supplementary material available at 10.1186/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
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Data
Datasets cited
- geo:GSE66287, at NCBI GEO; found in the text, “Bioinformatic screening of ferroptosis-related…”
Data availability
The metabolomics data are available in Synapse under Project SynID syn75980291. The transcriptome sequencing data are available in NCBI under accession number PRJNA1477317.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 4 keywords, 16 MeSH terms, 2 funders, 55 references.
Cite
This paper
Li, Z., Gao, J., Fu, J., Zhang, X., Zhou, Y., Li, C., Nam, J., & Gao, H. (2026). Silencing arachidonate 15-lipoxygenase alleviates hypoxia-induced cognitive impairment through the mediation of phospholipase A2 group IVC-LPC18:0 to suppress ferroptosis. Molecular biomedicine, 7(1), 152. https://
BibTeX
@article{li2026silencing
author = {Li, Zhen and Gao, Jie and Fu, Jun and Zhang, Xi and Zhou, Yiyang and Li, Chen and Nam, Jutaek and Gao, Hongchang},
title = {{Silencing arachidonate 15-lipoxygenase alleviates hypoxia-induced cognitive impairment through the mediation of phospholipase A2 group IVC-LPC18:0 to suppress ferroptosis}},
journal = {Molecular biomedicine},
year = {2026},
month = aug,
volume = {7},
number = {1},
pages = {152},
publisher = {Springer},
issn = {2662-8651},
doi = {10.1186/
url = {https://
pmid = {42645726},
pmcid = {PMC13518694}
}
RIS
TY - JOUR
AU - Li, Zhen
AU - Gao, Jie
AU - Fu, Jun
AU - Zhang, Xi
AU - Zhou, Yiyang
AU - Li, Chen
AU - Nam, Jutaek
AU - Gao, Hongchang
TI - Silencing arachidonate 15-lipoxygenase alleviates hypoxia-induced cognitive impairment through the mediation of phospholipase A2 group IVC-LPC18:0 to suppress ferroptosis
T2 - Molecular biomedicine
J2 - Mol Biomed
PY - 2026
DA - 2026/
VL - 7
IS - 1
SP - 152
SN - 2662-8651
PB - Springer
DO - 10.1186/
UR - https://
LA - en
ER -
CSL-JSON
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"URL": "https://
"language": "en",
"issued": {
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