Cat brains age like humans: translating time shows pet cats live to be natural models for human aging.
The 5 matches
- [1] § MATERIALS AND METHODS › Comparison of MRI data with other observations ↔ Supplemenrary_material 1.R, lines 604–670 · score 0.79 · standard deviation, bootstrapped sample, bootstrapped predictions, prediction intervals, replacement, spar
- [2] § RESULTS › Diverse feline populations are used to translate ages across species ↔ Supplementary material 2.R, lines 1–40 · score 0.74 · blood chemistry profiles, age related variation, age alignments, colony cats, alkaline, phosphorus
- [3] § MATERIALS AND METHODS › Blood chemistry profiles from the colony and Auburn CVM ↔ Supplementary material 2.R, lines 1–40 · score 0.65 · Blood chemistry profiles, colony cats, healthy, SRRC, females
- [4] § RESULTS › Domestic cats and wildcats are similar in their pace of development ↔ Supplementary material 4.R, lines 1–37 · score 0.64 · domestic cat, breed cat, wildcats, captive, slope, pace
- [5] § RESULTS › Translating time shows the pace of development and aging follows a complex trajectory ↔ Supplemenrary_material 1.R, lines 476–518 · score 0.50 · general linear model, event scale, longer, mice, species, fitted
Paper
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The authors' code
R · 672 lines · 25 KB · no license · 2 matches
Supplemenrary_material 1.R, no license · at the source
Overview
- Department of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
- Ecole Nationale Vétérinaire de Toulouse, Toulouse 31076, France
- Scott-Ritchey-Research Center, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA
- Centre for Accountable, Responsible, and Transparent AI (ART-AI), Department of Computer Science, University of Bath, Bath BA2 7AY, UK
Abstract
Whether an animal can achieve a lifespan equivalent to a human in their 80s remains an open question. Cats may serve as valuable models for human aging because there is some evidence that they can develop human related aging patterns. Here, we leveraged 3754 observations extracted from age-related brain variation, blood chemistry profiles, and other data to equate ages across the lifespan of humans and cats. We used structural MR scans (7T and 3T MRI) from pet and colony cats to quantify age-related brain metrics during aging. Cat and human brains exhibit similar age-related patterns of brain atrophy. We used common patterns of brain change and other health-related metrics to generate age alignments across the lifespan to late stages of life (e.g. an 80-year-old human equates to a 15-year-old cat). We also collected observations across multiple cat populations, including pets, zoos, and colonies to encapsulate individual variation in cross-species age alignments. One major finding to emerge is that pet cats are studied at significantly older ages than colony cats, and pet cats demonstrate a high degree of age-related brain atrophy. We demonstrate that it is feasible to translate ages across the lifespan of humans and cats.
Reproduced under the paper's license (CC BY), from the paper cited above.
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supp:PMC13382973/biolopen-15-062604-Dataset1.zip
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supp:PMC13382973/biolopen-15-062604-Dataset2.zip
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- Supplementary material 2.R — R, 182 lines, 2 matches, not shown here
supp:PMC13382973/biolopen-15-062604-Dataset3.zip
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supp:PMC13382973/biolopen-15-062604-Dataset4.zip
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- Supplementary material 4.R — R, 50 lines, 1 match, not shown here
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 6 keywords, 8 MeSH terms, 2 funders, 62 references.
Cite
This paper
Januel, C., Morrow, E., Gibson, R., Gross, A., de Sousa, A. A., Rigby Dames, B. A., & Charvet, C. J. (2026). Cat brains age like humans: translating time shows pet cats live to be natural models for human aging. Biology open, 15(6), bio062604. https://
BibTeX
@article{januel2026cat,
author = {Januel, Capucine and Morrow, Elijah and Gibson, Ryan and Gross, Amanda and de Sousa, Alexandra A. and Rigby Dames, Brier A. and Charvet, Christine J.},
title = {{Cat brains age like humans: translating time shows pet cats live to be natural models for human aging}},
journal = {Biology open},
year = {2026},
month = jun,
volume = {15},
number = {6},
pages = {bio062604},
publisher = {Company of Biologists},
issn = {2046-6390},
doi = {10.1242/
url = {https://
pmid = {42145034},
pmcid = {PMC13382973}
}
RIS
TY - JOUR
AU - Januel, Capucine
AU - Morrow, Elijah
AU - Gibson, Ryan
AU - Gross, Amanda
AU - de Sousa, Alexandra A.
AU - Rigby Dames, Brier A.
AU - Charvet, Christine J.
TI - Cat brains age like humans: translating time shows pet cats live to be natural models for human aging
T2 - Biology open
J2 - Biol Open
PY - 2026
DA - 2026/
VL - 15
IS - 6
SP - bio062604
SN - 2046-6390
PB - Company of Biologists
DO - 10.1242/
UR - https://
LA - en
ER -
CSL-JSON
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