OSCR

Epigenetic and Transcriptomic Impacts of Ethanol Vary by Brain Region and Extent of Exposure.

Overview

Authors: Erica M Periandri1, Kala M Dodson1, Mariana Lopes2, Francisca N de Luna Vitorino3, Anjola Ola1, Joanna M Gongora3, Benjamin A Garcia3, Karl M Glastad4, Gabor Egervari1,3
ORCID iDs: Erica M Periandri, Kala M Dodson, Mariana Lopes, Francisca N de Luna Vitorino, Joanna M Gongora, Benjamin A Garcia, Karl M Glastad, Gabor Egervari
  1. Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110
  2. Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
  3. Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110
  4. Department of Biology, University of Rochester, Rochester, New York 14627
Institutions: Washington University in St. Louis (United States); Case Western Reserve University (United States); University of Rochester (United States)
Journal: eNeuro, volume 13, issue 4, pages ENEURO.0484-25.2026
Dates: received 30 December 2025; accepted 23 February 2026; published online 9 April 2026; in print April 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1523/eneuro.0484-25.2026 · PMID 41912333 · PMCID PMC13086551 · OpenAlex W7143307939
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), clinical / translational (subfield)
Methods: Statistics
Keywords: acute alcohol exposure, brain, chronic alcohol exposure, epigenetics, ethanol, transcriptomics
MeSH: Brain*, Central Nervous System Depressants*, Epigenesis, Genetic*, Ethanol*, Transcriptome*, Acetylation, Animals, Histones, Male, Mice, Mice, Inbred C57BL (* major topic)
Topic: Prenatal Substance Exposure Effects (Pediatrics, Perinatology and Child Health, Medicine), according to OpenAlex
Funding: NICHD NIH HHS (R01 HD106051); NIAAA NIH HHS (R00 AA028577); NINDS NIH HHS (R01 NS111997)
Citations: not cited yet (Europe PMC); 85 references in the paper
Research resources: RRID:IMSR_JAX:00064

Abstract

Epigenetic and transcriptional mechanisms are key contributors to alcohol use disorder (AUD). However, a better understanding of the specific genes, transcripts, and chromatin marks affected is necessary to inform novel pharmacotherapies. Here, we systematically investigate the genome-wide epigenetic and transcriptomic effects of ethanol across key brain regions relevant to AUD and assess how these outcomes differ between acute and chronic exposure in male C57BL/6J mice. We show that alcohol-derived acetate contributes to histone acetylation in the brain in response to acute or chronic exposure, with a broader and more robust effect following repeated exposure. Further, we find that chromatin and transcriptomic changes elicited by acute or chronic ethanol exposure are predominantly specific to brain region and observe more robust dysregulation of gene and transcript expression following acute exposure. We show that ethanol-induced transcriptional changes are paradigm dependent in some brain regions, most strikingly in the ventral hippocampus. Overall, our results systematically illuminate and compare key epigenetic and transcriptomic outcomes linked to acute and chronic ethanol exposure, which will guide the development of future therapeutic interventions.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Tracing map

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Data

Datasets cited

Data accessibility

All mass spectrometry and RNA sequencing data are publicly available at the time of publication. Mass spectrometry data have been deposited in the MassIVE Repository (accession: MSV000100736). RNA sequencing data have been deposited in the NCBI Gene Expression Omnibus (GEO; accession: GSE31424 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE31424)).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 6 keywords, 11 MeSH terms, 3 funders, 80 references, 1 RRID.

Cite

This paper

Periandri, E. M., Dodson, K. M., Lopes, M., de Luna Vitorino, F. N., Ola, A., Gongora, J. M., Garcia, B. A., Glastad, K. M., & Egervari, G. (2026). Epigenetic and Transcriptomic Impacts of Ethanol Vary by Brain Region and Extent of Exposure. eNeuro, 13(4), ENEURO.0484-25.2026. https://doi.org/10.1523/eneuro.0484-25.2026

BibTeX

@article{periandri2026epigenetic,
author = {Periandri, Erica M and Dodson, Kala M and Lopes, Mariana and de Luna Vitorino, Francisca N and Ola, Anjola and Gongora, Joanna M and Garcia, Benjamin A and Glastad, Karl M and Egervari, Gabor},
title = {{Epigenetic and Transcriptomic Impacts of Ethanol Vary by Brain Region and Extent of Exposure}},
journal = {eNeuro},
year = {2026},
month = apr,
volume = {13},
number = {4},
pages = {ENEURO.0484--25.2026},
publisher = {Society for Neuroscience},
issn = {2373-2822},
doi = {10.1523/eneuro.0484-25.2026},
url = {https://doi.org/10.1523/eneuro.0484-25.2026},
pmid = {41912333},
pmcid = {PMC13086551}
}

RIS

TY - JOUR
AU - Periandri, Erica M
AU - Dodson, Kala M
AU - Lopes, Mariana
AU - de Luna Vitorino, Francisca N
AU - Ola, Anjola
AU - Gongora, Joanna M
AU - Garcia, Benjamin A
AU - Glastad, Karl M
AU - Egervari, Gabor
TI - Epigenetic and Transcriptomic Impacts of Ethanol Vary by Brain Region and Extent of Exposure
T2 - eNeuro
J2 - eNeuro
PY - 2026
DA - 2026/04/16
VL - 13
IS - 4
SP - ENEURO.0484
EP - 25.2026
SN - 2373-2822
PB - Society for Neuroscience
DO - 10.1523/eneuro.0484-25.2026
UR - https://doi.org/10.1523/eneuro.0484-25.2026
LA - en
ER -

CSL-JSON

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