Pharmacological Inhibition of Tropomyosin Receptor Kinase B Reverses Remifentanil-Induced Postoperative Hyperalgesia and Synaptic Remodeling.

Overview

Authors: Lijun Yang¹, Yu Huang¹, Bo Long²

ORCID iDs: Bo Long

Department of Anesthesiology,Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350001, People’s Republic of China
Department of Anesthesiology,The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, 350001, People’s Republic of China

Institutions: Fujian Medical University (China); Fujian Women and Children Hospital (China); Fujian University of Traditional Chinese Medicine (China)

Journal: Journal of pain research, volume 19, article 598801

Dates: received 27 January 2026; accepted 17 June 2026; published online 29 June 2026

Type: Research article · Language: English

License: CC BY-NC

Identifiers: DOI 10.2147/jpr.s598801 · PMID 42404688 · PMCID PMC13331029 · OpenAlex W7166558976

Open access: gold, a free copy (OpenAlex)

Status: data only

Categories: rat (organism), pain (population), cellular / molecular (subfield)

Methods: Statistics, Physiology & signal measures

Keywords: remifentanil, hyperalgesia, tropomyosin receptor kinase B, brain-derived neurotrophic factor, neuroplasticity

Topic: Pain Mechanisms and Treatments (Physiology, Medicine), according to OpenAlex

Funding: Joint Funds for the Innovation of Science and Technology, Fujian province

Citations: not cited yet (Europe PMC); 34 references in the paper

Abstract

Purpose: This study investigated the contributions of tropomyosin receptor kinase B (TrkB) signaling to behavioral hyperalgesia and associated spinal synaptic and dendritic remodeling in the rat remifentanil-induced hyperalgesia (RIH) model.

Methods: Forty rats were randomly assigned to four treatment groups (n = 10/group): normal saline + TrkB inhibitor (NS + ANA), surgical incision of the hind paw (I), remifentanil + incision (IR), and remifentanil + incision + TrkB inhibitor (IR + ANA). Paw mechanical withdrawal threshold (PMWT), expression levels of Brain-derived neurotrophic factor (BDNF), TrkB, and synaptic proteins, and dendritic morphology were compared among groups.

Results: Rats in the IR group exhibited significantly reduced mechanical pain thresholds and elevated expression levels of BDNF, TrkB, the glutamate receptor 1 subunit (GluR1), postsynaptic density protein 95 (PSD-95), and synapsin compared to the I group at 48 h post-surgery. In addition, IR rats had longer spinal dendrites with greater branching complexity. Administration of a TrkB inhibitor (IR + ANA group) reversed all these changes, with the exception of upregulated BDNF expression.

Conclusion: This study provides molecular and morphological evidence that TrkB inhibition reverses synaptic structural remodeling in RIH, suggesting TrkB as a potential therapeutic target. The feasibility of TrkB inhibitors for human postoperative hyperalgesia warrants further investigation.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

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Data

Datasets cited

doi:10.7910/dvn/ej82ij, at the source; found in the references

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 3 authors, 5 keywords, 1 funder, 34 references.

Cite

This paper

Yang, L., Huang, Y., & Long, B. (2026). Pharmacological Inhibition of Tropomyosin Receptor Kinase B Reverses Remifentanil-Induced Postoperative Hyperalgesia and Synaptic Remodeling. Journal of pain research, 19, 598801. https://doi.org/10.2147/jpr.s598801

BibTeX

@article{yang2026pharmacological, author = {Yang, Lijun and Huang, Yu and Long, Bo}, title = {{Pharmacological Inhibition of Tropomyosin Receptor Kinase B Reverses Remifentanil-Induced Postoperative Hyperalgesia and Synaptic Remodeling}}, journal = {Journal of pain research}, year = {2026}, month = jun, volume = {19}, pages = {598801}, publisher = {Dove Press}, issn = {1178-7090}, doi = {10.2147/jpr.s598801}, url = {https://doi.org/10.2147/jpr.s598801}, pmid = {42404688}, pmcid = {PMC13331029} }

RIS

TY - JOUR AU - Yang, Lijun AU - Huang, Yu AU - Long, Bo TI - Pharmacological Inhibition of Tropomyosin Receptor Kinase B Reverses Remifentanil-Induced Postoperative Hyperalgesia and Synaptic Remodeling T2 - Journal of pain research J2 - J Pain Res PY - 2026 DA - 2026/06/29 VL - 19 SP - 598801 SN - 1178-7090 PB - Dove Press DO - 10.2147/jpr.s598801 UR - https://doi.org/10.2147/jpr.s598801 LA - en ER -

CSL-JSON

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