Prenatal and neonatal housing conditions affect anxiety-like behavior in adulthood in rats and interact with brain-derived neurotrophic factor (BDNF) Val66Met to alter expression of BDNF and stress markers in the ventral hippocampus.
Overview
- School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia
- Biological Psychiatry Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy
- Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, Italy
Abstract
Introduction: We investigated the interaction of the brain-derived neurotrophic factor (BDNF) gene variant, Val66Met, with the effect of prenatal/
Methods: In a genetic Val66Met rat model, we compared the effects of a high-enrichment/
Results: Body weight and behavioral changes did not differ between BDNF genotypes. Fear conditioning and extinction were not affected. The effect of HE vs. LE condition on expression of BDNF, the antioxidant transcription factor, NRF2, and the glucocorticoid receptor, NR3C1, in the ventral hippocampus varied depending on genotype, and most of these changes were again only seen in females. There were no effects on the expression of the stress markers, SGK1 and FKBP5, or the mineralocorticoid receptor, NR3C2.
Discussion: These results show persistent effects of early-life environment on anxiety-like behavior and gene expression of BDNF and stress markers in adulthood, with some effects showing sex- and Val66Met genotype specificity. These results may be important for our understanding of factors involved in the development of clinical anxiety and depression, and also have implications for animal welfare in the laboratory setting.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:32754111, at figshare; found in “Data availability statement”
Data availability statement
The original contributions presented in the study are publicly available. This data can be found here: https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 2, 28 September 2026
- Funding: added Università degli Studi di Milano; La Trobe University
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 6 authors, 5 keywords, 102 references.
Cite
This paper
van den Buuse, M., Corrone, M., Jaehne, E. J., Begni, V., Marchesin, A., & Riva, M. A. (2026). Prenatal and neonatal housing conditions affect anxiety-like behavior in adulthood in rats and interact with brain-derived neurotrophic factor (BDNF) Val66Met to alter expression of BDNF and stress markers in the ventral hippocampus. Frontiers in molecular neuroscience, 19, 1844602. https://
BibTeX
@article{vandenbuuse2026
author = {van den Buuse, Maarten and Corrone, Michelle and Jaehne, Emily J. and Begni, Veronica and Marchesin, Alessia and Riva, Marco A.},
title = {{Prenatal and neonatal housing conditions affect anxiety-like behavior in adulthood in rats and interact with brain-derived neurotrophic factor (BDNF) Val66Met to alter expression of BDNF and stress markers in the ventral hippocampus}},
journal = {Frontiers in molecular neuroscience},
year = {2026},
month = jul,
volume = {19},
pages = {1844602},
publisher = {Frontiers Media SA},
issn = {1662-5099},
doi = {10.3389/
url = {https://
pmid = {42488725},
pmcid = {PMC13388326}
}
RIS
TY - JOUR
AU - van den Buuse, Maarten
AU - Corrone, Michelle
AU - Jaehne, Emily J.
AU - Begni, Veronica
AU - Marchesin, Alessia
AU - Riva, Marco A.
TI - Prenatal and neonatal housing conditions affect anxiety-like behavior in adulthood in rats and interact with brain-derived neurotrophic factor (BDNF) Val66Met to alter expression of BDNF and stress markers in the ventral hippocampus
T2 - Frontiers in molecular neuroscience
J2 - Front Mol Neurosci
PY - 2026
DA - 2026/
VL - 19
SP - 1844602
SN - 1662-5099
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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"container-title": "Frontiers in molecular neuroscience",
"author": [
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"given": "Veronica"
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"given": "Alessia"
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"family": "Riva",
"given": "Marco A."
}
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"volume": "19",
"page": "1844602",
"DOI": "10.3389/
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"URL": "https://
"language": "en",
"issued": {
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