Sex-specific alterations in CRF and dopaminergic markers in the lateral septum and mesolimbic system following chronic high-fat diet exposure in rats.
Overview
- Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile
- Programa de Doctorado en Ciencias Mención Neurociencia, Universidad de Valparaíso, Valparaíso, Chile
- Instituto de Biología, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile
- Programa de Doctorado en Ciencias e Ingeniería para la Salud, Universidad de Valparaíso, Valparaíso, Chile
- Departamento de Ciencias Veterinarias, Facultad de Ciencias de la Vida, Universidad Viña del Mar, Viña del Mar, Chile
- Centro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, Chile
- Departamento de Ciencias Químicas y Recursos Naturales, Facultad de Ingeniería y Ciencias, Universidad de la Frontera, Temuco, Chile
- Grupo de NeuroGastroBioquímica, Instituto de Química, Facultad de Ciencias, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile
- Millennium Nucleus of Neuroepigenetics and Plasticity (EpiNeuro), Santiago, Chile
Abstract
Background: Obesity is a global health concern closely associated with sedentary lifestyles and the consumption of hypercaloric, hyperpalatable diets. While these factors contribute to excessive food intake and weight gain, the long-term impact of obesogenic diets on neural circuits regulating energy balance remains insufficiently understood. Previous research has identified the lateral septum (LS) as a critical structure involved in stress responses and addiction, with corticotropin-releasing factor (CRF) and dopaminergic signalling playing key roles. However, the influence of chronic high fat diet (HFD) exposure on LS function and its contribution to feeding regulation remains poorly characterized.
Methods and Results: Male and female Sprague–Dawley rats were fed either a high fat diet (HFD) or standard chow from postnatal day 21–62. Chronic HFD exposure induced anxiolytic-like behavior and increased CRF in the LS of males. In females, HFD elevated dopamine D1 and D2 receptor expression, as well as CRF receptor type 2 (CRF2), compared to controls. Moreover, dopamine metabolite levels were elevated in mesolimbic regions in both sexes following HFD exposure.
Conclusion: These results indicate that the LS undergoes sex-specific molecular and cellular alterations in response to prolonged HFD consumption. The observed alterations in dopamine and CRF signalling suggest that the LS may mediate diet-induced dysregulation of both homeostatic and hedonic aspects of feeding. These findings provide novel insights into the neural mechanisms by which chronic exposure to an obesogenic diet may promote overeating and obesity.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- zenodo:19632378, at Zenodo; found in “Data availability statement”
Data availability statement
The data presented in the study are deposited in the zenodo repository, accession number https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 10 authors, 5 keywords, 59 references.
Cite
This paper
Olivares-Barraza, R., Marcos, J. L., Escobar-Luna, J., Covarrubias, M. J., Renard, G. M., Iturriaga-Vásquez, P., Gysling, K., Bravo, J. A., Fuenzalida, M., & Sotomayor-Zárate, R. (2026). Sex-specific alterations in CRF and dopaminergic markers in the lateral septum and mesolimbic system following chronic high-fat diet exposure in rats. Frontiers in pharmacology, 17, 1781720. https://
BibTeX
@article{olivaresbarraza
author = {Olivares-Barraza, Rossy and Marcos, José L. and Escobar-Luna, Jorge and Covarrubias, María José and Renard, Georgina M. and Iturriaga-Vásquez, Patricio and Gysling, Katia and Bravo, Javier A. and Fuenzalida, Marco and Sotomayor-Zárate, Ramón},
title = {{Sex-specific alterations in CRF and dopaminergic markers in the lateral septum and mesolimbic system following chronic high-fat diet exposure in rats}},
journal = {Frontiers in pharmacology},
year = {2026},
month = apr,
volume = {17},
pages = {1781720},
publisher = {Frontiers Media SA},
issn = {1663-9812},
doi = {10.3389/
url = {https://
pmid = {42147343},
pmcid = {PMC13172626}
}
RIS
TY - JOUR
AU - Olivares-Barraza, Rossy
AU - Marcos, José L.
AU - Escobar-Luna, Jorge
AU - Covarrubias, María José
AU - Renard, Georgina M.
AU - Iturriaga-Vásquez, Patricio
AU - Gysling, Katia
AU - Bravo, Javier A.
AU - Fuenzalida, Marco
AU - Sotomayor-Zárate, Ramón
TI - Sex-specific alterations in CRF and dopaminergic markers in the lateral septum and mesolimbic system following chronic high-fat diet exposure in rats
T2 - Frontiers in pharmacology
J2 - Front Pharmacol
PY - 2026
DA - 2026/
VL - 17
SP - 1781720
SN - 1663-9812
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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