Transvenous Embolisation-Based Strategies for Brain Arteriovenous Malformations: Systematic Review and Meta-Analysis.

Overview

Authors: Sergiu-Florin Arnautu^1,2,3, Hamed Nejadhamzeeigilani⁴, Tufail Patankar³, Rory Fairhead⁵, Sara Sciacca⁶, Mohd Shariq³, Prem Rangi⁷, Dragos-Catalin Jianu^1,8, Claudiu-Daniel Malita⁹, Aida-Lorenta Iancu⁹, Catalin Juratu^10,11, Stela Iurciuc¹², Minodora Andor², Alison Cousins¹³, Diana-Aurora Arnautu^2,14, Jeremy Lynch³

ORCID iDs: Sergiu-Florin Arnautu, Mohd Shariq, Dragos-Catalin Jianu, Stela Iurciuc, Diana-Aurora Arnautu

14 affiliations

Institutions: Barking, Havering And Redbridge University Hospitals NHS Trust (United Kingdom); Victor Babeș University of Medicine and Pharmacy Timișoara (Romania); Leeds General Infirmary (United Kingdom); Leeds Teaching Hospitals NHS Trust (United Kingdom); Barts Health NHS Trust (United Kingdom); Royal London Hospital (United Kingdom); King's College Hospital NHS Foundation Trust (United Kingdom); King's College Hospital (United Kingdom); University College London Hospitals NHS Foundation Trust (United Kingdom); National Hospital for Neurology and Neurosurgery (United Kingdom); Spitalul Clinic Judeţean de Urgenţă "Pius Brînzeu" Timişoara (Romania); King's College London (United Kingdom); University of Leeds (United Kingdom)

Journal: Biomedicines, volume 14, issue 8, article 1829

Dates: received 15 July 2026; accepted 11 August 2026; published online 14 August 2026

Type: Review · Language: English

License: CC BY

Identifiers: DOI 10.3390/biomedicines14081829 · PMID 42652211 · PMCID PMC13510176 · OpenAlex W7203471897

Open access: gold, a free copy (OpenAlex)

Status: code on request

Categories: other (modality), human (organism), stroke (population), clinical / translational (subfield)

Methods: Statistics

Keywords: brain arteriovenous malformation, transvenous embolisation, endovascular treatment, embolisation, neuro-intervention, angiographic occlusion, functional outcome, systematic review, meta-analysis, modified Rankin Scale, cerebrovascular disorders

Topic: Vascular Malformations Diagnosis and Treatment (Neurology, Medicine), according to OpenAlex

Citations: not cited yet (Europe PMC); 30 references in the paper

Abstract

Background: Transvenous embolisation (TVE) has emerged as a promising treatment option for selected brain arteriovenous malformations (bAVMs). Objective: To evaluate the safety and efficacy of TVE-based treatment strategies for bAVMs. Methods: This Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020-compliant systematic review and meta-analysis was registered in PROSPERO (CRD420261397818). PubMed, Embase, Cochrane CENTRAL, and Scopus were searched on 20 May 2026, supplemented by citation screening. Studies reporting TVE for bAVMs in ≥5 patients were included. Binary outcomes were pooled using random-effects binomial-normal generalised linear mixed models (GLMMs) with a logit link under an intention-to-treat framework. Results: Twelve studies comprising 239 patients were included; 57.7% underwent combined transarterial/transvenous embolisation. Complete angiographic occlusion was 92.2% (217/239; 95% CI, 84.5–96.2%; I2 = 0%) overall and 97.1% (149/160; 95% CI, 76.6–99.7%; I2 = 0%) among patients with ≥3 months of imaging follow-up. Functional independence (mRS 0–2) was 85.0% (155/180; 95% CI, 68.7–93.7%; I2 = 55%), and technical success was 97.1% (219/227; 95% CI, 91.5–99.0%; I2 = 0%). GLMM pooled rates were 0.7% for ischaemic complications, 12.3% for haemorrhagic complications, 3.3% for permanent neurological morbidity, 2.3% for overall mortality, 0.8% for procedure-related mortality, and 13.9% for any procedure-related complication or death. Conclusions: TVE-based strategies are associated with high angiographic occlusion and favourable functional outcomes in carefully selected bAVMs, but the evidence is predominantly observational and safety estimates remain uncertain. As most patients underwent combined transarterial/transvenous treatment, these findings should not be interpreted as estimates of standalone TVE.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

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Data

No dataset and no data link were found in the paper.

Data Availability Statement

The extracted study-level dataset, statistical code, and Supplementary Review Materials are available from the corresponding author upon reasonable request.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 11 keywords, 30 references.

Cite

This paper

Arnautu, S.-F., Nejadhamzeeigilani, H., Patankar, T., Fairhead, R., Sciacca, S., Shariq, M., Rangi, P., Jianu, D.-C., Malita, C.-D., Iancu, A.-L., Juratu, C., Iurciuc, S., Andor, M., Cousins, A., Arnautu, D.-A., & Lynch, J. (2026). Transvenous Embolisation-Based Strategies for Brain Arteriovenous Malformations: Systematic Review and Meta-Analysis. Biomedicines, 14(8), 1829. https://doi.org/10.3390/biomedicines14081829

BibTeX

@article{arnautu2026transvenous, author = {Arnautu, Sergiu-Florin and Nejadhamzeeigilani, Hamed and Patankar, Tufail and Fairhead, Rory and Sciacca, Sara and Shariq, Mohd and Rangi, Prem and Jianu, Dragos-Catalin and Malita, Claudiu-Daniel and Iancu, Aida-Lorenta and Juratu, Catalin and Iurciuc, Stela and Andor, Minodora and Cousins, Alison and Arnautu, Diana-Aurora and Lynch, Jeremy}, title = {{Transvenous Embolisation-Based Strategies for Brain Arteriovenous Malformations: Systematic Review and Meta-Analysis}}, journal = {Biomedicines}, year = {2026}, month = aug, volume = {14}, number = {8}, pages = {1829}, publisher = {Multidisciplinary Digital Publishing Institute (MDPI)}, issn = {2227-9059}, doi = {10.3390/biomedicines14081829}, url = {https://doi.org/10.3390/biomedicines14081829}, pmid = {42652211}, pmcid = {PMC13510176} }

RIS

TY - JOUR AU - Arnautu, Sergiu-Florin AU - Nejadhamzeeigilani, Hamed AU - Patankar, Tufail AU - Fairhead, Rory AU - Sciacca, Sara AU - Shariq, Mohd AU - Rangi, Prem AU - Jianu, Dragos-Catalin AU - Malita, Claudiu-Daniel AU - Iancu, Aida-Lorenta AU - Juratu, Catalin AU - Iurciuc, Stela AU - Andor, Minodora AU - Cousins, Alison AU - Arnautu, Diana-Aurora AU - Lynch, Jeremy TI - Transvenous Embolisation-Based Strategies for Brain Arteriovenous Malformations: Systematic Review and Meta-Analysis T2 - Biomedicines J2 - Biomedicines PY - 2026 DA - 2026/08/14 VL - 14 IS - 8 SP - 1829 SN - 2227-9059 PB - Multidisciplinary Digital Publishing Institute (MDPI) DO - 10.3390/biomedicines14081829 UR - https://doi.org/10.3390/biomedicines14081829 LA - en ER -

CSL-JSON

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