OSCR

Subchronic PAH Exposure Impacts Cardiac Electrophysiology of the Polar Fish, Navaga Cod (<i>Eleginus nawaga</i>).

Overview

Authors: Irina Dzhumaniiazova1, Tatiana S Filatova1, Artem V Shamshura1, Denis V Abramochkin1,2
ORCID iDs: Irina Dzhumaniiazova, Artem V Shamshura, Denis V Abramochkin
  1. Department of Human and Animal Physiology, Faculty of Biology, Lomonosov Moscow State University, 119234 Moscow, Russia; (I.D.)
  2. Institute of Physiology, Pirogov Russian National Research Medical University, Ostrovityanova Str., 117513 Moscow, Russia
Institutions: Lomonosov Moscow State University (Russia); Pirogov Russian National Research Medical University (Russia)
Journal: Toxics, volume 14, issue 8, article 674
Dates: received 12 June 2026; accepted 26 July 2026; published online 30 July 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.3390/toxics14080674 · PMID 42646956 · PMCID PMC13517624 · OpenAlex W7171873179
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: intracellular / patch clamp (modality)
Methods: Statistics
Keywords: polycyclic aromatic hydrocarbons, phenanthrene, 3-methylphenanthrene, cardiomyocytes, patch-clamp, ionic currents, action potential, fish heart
Topic: Environmental Toxicology and Ecotoxicology (Health, Toxicology and Mutagenesis, Environmental Science), according to OpenAlex
Funding: Russian Science Foundation (22-14-00075)
Citations: not cited yet (Europe PMC); 50 references in the paper

Abstract

Polycyclic aromatic hydrocarbons (PAHs) from the water-soluble fraction (WSF) of crude oil are recognized cardiotoxicants in fish; however, all electrophysiological evidence to date derives from acute exposure experiments. This study examined the effects of prolonged (5–8 h) incubation of isolated ventricular cardiomyocytes from the navaga cod (Eleginus nawaga, Walbaum, 1792) with 10% WSF (total dissolved tricyclic-PAH concentration in the tens-of-nM), 3 µM phenanthrene (Phe), or 3 µM 3-methylphenanthrene (3-MP) on action potential (AP) parameters and the underlying ionic currents using the whole-cell patch-clamp technique. WSF and 3-MP reduced AP amplitude and maximum rate of depolarization through suppression of the fast sodium current (INa), whereas Phe and 3-MP shortened AP duration, associated with decreased density and a hyperpolarizing shift in steady-state activation of the rapid delayed rectifier potassium current (IKr). The L-type calcium current and inward rectifier potassium current remained unaffected by all treatments. Notably, the effects of prolonged incubation differed qualitatively from previously reported acute responses to the same compounds, suggesting the involvement of indirect mechanisms such as reactive oxygen species production and activation of intracellular signaling cascades. These findings demonstrate that subchronic PAH exposure produces distinct and potentially proarrhythmogenic alterations in fish cardiac electrophysiology that cannot be predicted from acute exposure data alone.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

Data Availability Statement

The original data presented in the study are openly available at https://shorturl.at/NMhiR (accessed on 25 July 2026) (DOI: 10.5281/zenodo.20763230).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 8 keywords, 1 funder, 49 references.

Cite

This paper

Dzhumaniiazova, I., Filatova, T. S., Shamshura, A. V., & Abramochkin, D. V. (2026). Subchronic PAH Exposure Impacts Cardiac Electrophysiology of the Polar Fish, Navaga Cod (<i>Eleginus nawaga</i>). Toxics, 14(8), 674. https://doi.org/10.3390/toxics14080674

BibTeX

@article{dzhumaniiazova2026subchronic,
author = {Dzhumaniiazova, Irina and Filatova, Tatiana S and Shamshura, Artem V and Abramochkin, Denis V},
title = {{Subchronic PAH Exposure Impacts Cardiac Electrophysiology of the Polar Fish, Navaga Cod (\<i\>Eleginus nawaga\</i\>)}},
journal = {Toxics},
year = {2026},
month = jul,
volume = {14},
number = {8},
pages = {674},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {2305-6304},
doi = {10.3390/toxics14080674},
url = {https://doi.org/10.3390/toxics14080674},
pmid = {42646956},
pmcid = {PMC13517624}
}

RIS

TY - JOUR
AU - Dzhumaniiazova, Irina
AU - Filatova, Tatiana S
AU - Shamshura, Artem V
AU - Abramochkin, Denis V
TI - Subchronic PAH Exposure Impacts Cardiac Electrophysiology of the Polar Fish, Navaga Cod (<i>Eleginus nawaga</i>)
T2 - Toxics
J2 - Toxics
PY - 2026
DA - 2026/07/30
VL - 14
IS - 8
SP - 674
SN - 2305-6304
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/toxics14080674
UR - https://doi.org/10.3390/toxics14080674
LA - en
ER -

CSL-JSON

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"id": "10.3390/toxics14080674",
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"title": "Subchronic PAH Exposure Impacts Cardiac Electrophysiology of the Polar Fish, Navaga Cod (<i>Eleginus nawaga</i>)",
"container-title": "Toxics",
"author": [
{
"family": "Dzhumaniiazova",
"given": "Irina"
},
{
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"given": "Tatiana S"
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"container-title-short": "Toxics",
"volume": "14",
"issue": "8",
"page": "674",
"DOI": "10.3390/toxics14080674",
"PMID": "42646956",
"PMCID": "PMC13517624",
"ISSN": "2305-6304",
"publisher": "Multidisciplinary Digital Publishing Institute (MDPI)",
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"language": "en",
"issued": {
"date-parts": [
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}
}

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