Structures of the volume-regulated anion channel LRRC8A/D in activating and inhibiting conditions.
Overview
Abstract
Volume-regulated anion channels, which are activated in response to hypotonicity, are heteromers composed of LRRC8 family members. They consist of the obligatory subunit LRRC8A and at least another paralog that determines their substrate preference. Here we investigate heteromeric assemblies composed of LRRC8A and D subunits, the latter of which confer permeability to amino acids, osmolytes and anti-cancer drugs. Using patch-clamp electrophysiology, we show that LRRC8A/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- ebi.ac.uk/
emdb/ , at EMBL-EBI; found in “Data availability”emd-55589 - ebi.ac.uk/
emdb/ , at EMBL-EBI; found in “Data availability”emd-55590 - ebi.ac.uk/
emdb/ , at EMBL-EBI; found in “Data availability”emd-55591 - ebi.ac.uk/
emdb/ , at EMBL-EBI; found in “Data availability”emd-55592
Data availability
The three-dimensional cryo-EM density maps generated in this study have been deposited in the Electron Microscopy Data Bank under accession numbers EMD-55589 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 4 keywords, 12 MeSH terms, 2 funders, 59 references.
Cite
This paper
Lehmann, E. F., Stierli, F., Rutz, S., Deneka, D., & Dutzler, R. (2026). Structures of the volume-regulated anion channel LRRC8A/
BibTeX
@article{lehmann2026stru
author = {Lehmann, Elena F. and Stierli, Fabienne and Rutz, Sonja and Deneka, Dawid and Dutzler, Raimund},
title = {{Structures of the volume-regulated anion channel LRRC8A/
journal = {Nature communications},
year = {2026},
month = sep,
volume = {17},
number = {1},
pages = {9884},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/
url = {https://
pmid = {42754598},
pmcid = {PMC13586245}
}
RIS
TY - JOUR
AU - Lehmann, Elena F.
AU - Stierli, Fabienne
AU - Rutz, Sonja
AU - Deneka, Dawid
AU - Dutzler, Raimund
TI - Structures of the volume-regulated anion channel LRRC8A/
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/
VL - 17
IS - 1
SP - 9884
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
{
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"title": "Structures of the volume-regulated anion channel LRRC8A/
"container-title": "Nature communications",
"author": [
{
"family": "Lehmann",
"given": "Elena F."
},
{
"family": "Stierli",
"given": "Fabienne"
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{
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"given": "Sonja"
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{
"family": "Deneka",
"given": "Dawid"
},
{
"family": "Dutzler",
"given": "Raimund"
}
],
"container-title-short":
"volume": "17",
"issue": "1",
"page": "9884",
"DOI": "10.1038/
"PMID": "42754598",
"PMCID": "PMC13586245",
"ISSN": "2041-1723",
"publisher": "Nature Publishing Group",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
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2026,
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}
}
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