A Dual-Mode Wireless Microsystem for Monitoring Dopamine and Spike Changes with Dexmedetomidine.

Overview

Authors: Peiyao Jiao^1,2, Yilin Song^1,2, Jin Shan^1,2, Yu Liu^1,2, Qianli Jia^1,2, Qi Li³, Ying Wang³, Yan Luo³, Pengfei Zhao⁴, Juntao Liu^1,2, Zhenchang Wang⁴, Mixia Wang^1,2, Xinxia Cai^1,2

ORCID iDs: Mixia Wang, Xinxia Cai

State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China
School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China
Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Institutions: Chinese Academy of Sciences (China); State Key Laboratory of Transducer Technology (China); Aerospace Information Research Institute (China); University of Chinese Academy of Sciences (China); Shanghai Jiao Tong University (China); Ruijin Hospital (China); Capital Medical University (China); Beijing Friendship Hospital (China)

Journal: Cyborg and bionic systems (Washington, D.C.), volume 7, article 0566

Dates: received 6 January 2026; accepted 17 March 2026; published online 21 May 2026

Type: Research article · Language: English

License: CC BY

Identifiers: DOI 10.34133/cbsystems.0566 · PMID 42182932 · PMCID PMC13191085 · OpenAlex W7140120971

Open access: diamond, a free copy (OpenAlex)

Status: code on request

Categories: extracellular electrophysiology (units, LFP) (modality)

Methods: Statistics, Preprocessing, Evoked potentials, Single-unit activity, calcium imaging

Topic: Neuroscience and Neural Engineering (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex

Funding: National Natural Science Foundation of China (T2293731, 62333020, T2293730, 62471291, 62171434, 62121003)

Citations: cited by 1 paper (Europe PMC); 39 references in the paper

Abstract

To understand how cortical circuits respond to pharmacological regulation, tools that can simultaneously detect electrophysiological and electrochemical signals in vivo are needed. However, most existing methods target only a single modality or depend on tethered recording systems that constrain movement and limit the ability to monitor coordinated neural processes. To address these challenges, we developed a dual-mode wireless microsystem that enables simultaneous recording of spikes, local field potentials (LFPs), and dopamine (DA)-related electrochemical signals on microelectrode arrays. The platform integrates a PtNPs/PEDOT:PSS/rGO/Nafion-modified electrochemical site for sensitive and selective detection of DA, as well as independent electrophysiological and electrochemical acquisition pathways that support stable long-distance wireless transmission of dual-mode signals. In vitro tests demonstrated that the platform can stably detect DA within a certain range and exhibits reliable wireless transmission performance. Using this platform, we recorded simultaneous electrophysiological and dopaminergic signals from the prelimbic cortex under different doses of dexmedetomidine. The results showed that increasing drug dose led to a significant reduction in spike firing rate and high-frequency LFP power, accompanied by dose-dependent elevations in DA-related amperometric response. These combined measurements showed simultaneous dose-dependent changes in electrophysiological activity and the DA-related electrochemical signal under dexmedetomidine. This dual-mode wireless microsystem provides a practical tool for neuroscience experiments requiring the integration of electrophysiology and neurochemistry.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

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Data Availability

All data needed to support the conclusions in the paper are provided in the paper and the Supplementary Materials. Representative raw data and additional datasets are available from the authors upon reasonable request. The analysis code used for signal processing is available from the authors upon reasonable request. Key system architecture details are provided in the paper and/or the Supplementary Materials, and further implementation details may be requested from the authors.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 2, 28 September 2026

Funding: added National Natural Science Foundation of China: T2293731, 62333020, T2293730, 62471291, 62171434, 62121003

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 13 authors, 30 references.

Cite

This paper

Jiao, P., Song, Y., Shan, J., Liu, Y., Jia, Q., Li, Q., Wang, Y., Luo, Y., Zhao, P., Liu, J., Wang, Z., Wang, M., & Cai, X. (2026). A Dual-Mode Wireless Microsystem for Monitoring Dopamine and Spike Changes with Dexmedetomidine. Cyborg and bionic systems (Washington, D.C.), 7, 0566. https://doi.org/10.34133/cbsystems.0566

BibTeX

@article{jiao2026dual, author = {Jiao, Peiyao and Song, Yilin and Shan, Jin and Liu, Yu and Jia, Qianli and Li, Qi and Wang, Ying and Luo, Yan and Zhao, Pengfei and Liu, Juntao and Wang, Zhenchang and Wang, Mixia and Cai, Xinxia}, title = {{A Dual-Mode Wireless Microsystem for Monitoring Dopamine and Spike Changes with Dexmedetomidine}}, journal = {Cyborg and bionic systems (Washington, D.C.)}, year = {2026}, month = may, volume = {7}, pages = {0566}, publisher = {AAAS Science Partner Journal Program}, issn = {2097-1087}, doi = {10.34133/cbsystems.0566}, url = {https://doi.org/10.34133/cbsystems.0566}, pmid = {42182932}, pmcid = {PMC13191085} }

RIS

TY - JOUR AU - Jiao, Peiyao AU - Song, Yilin AU - Shan, Jin AU - Liu, Yu AU - Jia, Qianli AU - Li, Qi AU - Wang, Ying AU - Luo, Yan AU - Zhao, Pengfei AU - Liu, Juntao AU - Wang, Zhenchang AU - Wang, Mixia AU - Cai, Xinxia TI - A Dual-Mode Wireless Microsystem for Monitoring Dopamine and Spike Changes with Dexmedetomidine T2 - Cyborg and bionic systems (Washington, D.C.) J2 - Cyborg Bionic Syst PY - 2026 DA - 2026/05/21 VL - 7 SP - 0566 SN - 2097-1087 PB - AAAS Science Partner Journal Program DO - 10.34133/cbsystems.0566 UR - https://doi.org/10.34133/cbsystems.0566 LA - en ER -

CSL-JSON

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