OSCR

Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis.

Overview

Authors: Shaocong Lu1, Fangla Luo1, Niqi Chen1, Gongde Shi1, Yeru Chen1
  1. Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China
Institutions: Sir Run Run Shaw Hospital (China); Zhejiang University (China)
Journal: Molecular medicine reports, volume 34, issue 3, article 257
Dates: received 29 January 2026; accepted 3 July 2026; published online 16 July 2026; in print September 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.3892/mmr.2026.13967 · PMID 42464680 · PMCID PMC13408541 · OpenAlex W7168555129
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), depression (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: depressive disorder, sedanolide, complement C3, microglia
MeSH: Depression*, Glycolysis*, Microglia*, Signal Transduction*, Animals, Behavior, Animal, Cell Line, Disease Models, Animal, Lipopolysaccharides, Male, Mice, Mice, Inbred C57BL (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: National Natural Science Foundation of China (82001424)
Citations: not cited yet (Europe PMC); 41 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.3892/mmr.2026.13967.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 4 keywords, 12 MeSH terms, 1 funder, 39 references.

Cite

This paper

Lu, S., Luo, F., Chen, N., Shi, G., & Chen, Y. (2026). Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis. Molecular medicine reports, 34(3), 257. https://doi.org/10.3892/mmr.2026.13967

BibTeX

@article{lu2026sedanolide,
author = {Lu, Shaocong and Luo, Fangla and Chen, Niqi and Shi, Gongde and Chen, Yeru},
title = {{Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis}},
journal = {Molecular medicine reports},
year = {2026},
month = jul,
volume = {34},
number = {3},
pages = {257},
publisher = {Spandidos Publications},
issn = {1791-2997},
doi = {10.3892/mmr.2026.13967},
url = {https://doi.org/10.3892/mmr.2026.13967},
pmid = {42464680},
pmcid = {PMC13408541}
}

RIS

TY - JOUR
AU - Lu, Shaocong
AU - Luo, Fangla
AU - Chen, Niqi
AU - Shi, Gongde
AU - Chen, Yeru
TI - Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis
T2 - Molecular medicine reports
J2 - Mol Med Rep
PY - 2026
DA - 2026/07/17
VL - 34
IS - 3
SP - 257
SN - 1791-2997
PB - Spandidos Publications
DO - 10.3892/mmr.2026.13967
UR - https://doi.org/10.3892/mmr.2026.13967
LA - en
ER -

CSL-JSON

{
"id": "10.3892/mmr.2026.13967",
"type": "article-journal",
"title": "Sedanolide alleviates LPS‑induced depressive‑like behaviors by modulating the C3a/C3aR signaling axis and microglial glycolysis",
"container-title": "Molecular medicine reports",
"author": [
{
"family": "Lu",
"given": "Shaocong"
},
{
"family": "Luo",
"given": "Fangla"
},
{
"family": "Chen",
"given": "Niqi"
},
{
"family": "Shi",
"given": "Gongde"
},
{
"family": "Chen",
"given": "Yeru"
}
],
"container-title-short": "Mol Med Rep",
"volume": "34",
"issue": "3",
"page": "257",
"DOI": "10.3892/mmr.2026.13967",
"PMID": "42464680",
"PMCID": "PMC13408541",
"ISSN": "1791-2997",
"publisher": "Spandidos Publications",
"URL": "https://doi.org/10.3892/mmr.2026.13967",
"language": "en",
"issued": {
"date-parts": [
[
2026,
7,
17
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1167/iovs.67.10.41
Ascl1 Represses Müller Glial and Promotes Rod Photoreceptor Fate Through Repressing Notch Signaling in Late Retinal Progenitor Cells.
Journal: Investigative ophthalmology & visual science
In common: genetics / omics, mouse, cellular / molecular, 2 references
[2] doi:10.1016/j.stemcr.2026.103012
Identification of novel genes with enriched expression in human intermediate progenitors reveals a key role for CDKN3 in cortical development.
Journal: Stem cell reports
In common: genetics / omics, mouse, cellular / molecular, 2 references
[3] doi:10.1097/shk.0000000000002867
Transcriptome and Experimental Verification Identified Candidate Biomarkers Related to Mitochondrial Metabolism in Sepsis-Associated Encephalopathy.
Journal: Shock (Augusta, Ga.)
In common: genetics / omics, mouse, 2 references
[4] doi:10.1002/cns.71080
Vorinostat Mitigates Early Brain Injury Following Subarachnoid Hemorrhage Through Modulation of the C3aR1/TGF-β/Smad Pathway.
Journal: CNS neuroscience & therapeutics
In common: mouse, cellular / molecular, 2 references
[5] doi:10.1186/s12864-026-12863-z [code]
Chromosome-level genome assembly of the nematophagous flatworm Luticola nematophagus: revealing molecular adaptations for predation and its biocontrol potential against nematode diseases.
Journal: BMC genomics
In common: cellular / molecular, 2 references
[6] doi:10.1186/s13041-026-01300-7
Hippocampal transcriptome profiling in a 22q11.2 deletion syndrome mouse model: comparison with human schizophrenia.
Journal: Molecular brain
In common: genetics / omics, mouse, cellular / molecular, 2 references
[7] doi:10.3390/ijms27146442
Phenotype-Specific Transcriptomic Responses to Glucocorticoid Signaling in the Prefrontal Cortex and Dorsal Raphe Nucleus Following Chronic Social Stress.
Journal: International journal of molecular sciences
In common: genetics / omics, mouse, 2 references
[8] doi:10.1186/s13072-026-00678-x
Host-cell dependent epigenetic profiles associated with survival outcomes in T. gondii infection.
Journal: Epigenetics & chromatin
In common: genetics / omics, mouse, 2 references
[9] doi:10.1186/s12974-026-03898-w
TGR5 is essential for protecting from chronic stress-induced learning and memory impairments in mice by modulating inflammation associated with the gut-brain axis.
Journal: Journal of neuroinflammation
In common: genetics / omics, mouse, cellular / molecular, 1 reference
[10] doi:10.1002/npr2.70150
Sleep Deprivation and Neuronal Hyperexcitation Share Transcriptomic Signatures.
Journal: Neuropsychopharmacology reports
In common: genetics / omics, mouse, cellular / molecular, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.