The antipsychotic drug clozapine suppresses autoimmunity driving psychosis-like behavior in mice
Overview
- Francis Crick Institute, London, United Kingdom
- School of Medical Sciences, Faculty of Health, University of Victoria, Victoria, Canada
- Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
- Peter Gorer Department of Immunobiology, King’s College, London, United Kingdom
- Division of Psychiatry, University College London, London, United Kingdom
- North London NHS Foundation Trust, London, United Kingdom
Abstract
Antipsychotic drugs are the first-line treatment for psychosis yet their mechanism of action remains poorly understood, largely due to the challenge to faithfully model psychosis preclinically. Here, we focus on the emerging concept that psychosis can be caused by brain autoimmunity and present a novel mouse model of anti-N-me-thyl-D-asparta
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FrancisCrickInstitute/HeFeldman2026
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- 30 September 2026: the link is dead
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Recorded: type, journal, dates, 18 authors, 5 keywords, 1 funder, 47 references, 17 RRIDs.
Cite
This paper
He, L., Feldman, H., Nguyen, T., Bosc, M., Polisetty, V., Kriel, O., Land-wehr, A., Borg, A., Subtil, F. T., Khakpour, M., Zhou, J., Kjær, S., MacCabe, J., Pollak, T. A., Tremblay, M.-E., Vinuesa, C. G., Hayday, A., & Schmack, K. (2026). The antipsychotic drug clozapine suppresses autoimmunity driving psychosis-like behavior in mice. bioRxiv (preprint). https://
BibTeX
@article{he2026antipsych
author = {He, Le and Feldman, Harriet and Nguyen, Timothy and Bosc, Marion and Polisetty, Vasishta and Kriel, Orla and Land-wehr, Antonia and Borg, Annabel and Subtil, Fernanda Teixera and Khakpour, Mohammadparsa and Zhou, Jitong and Kjær, Svend and MacCabe, James and Pollak, Thomas A. and Tremblay, Marie-Eve and Vinuesa, Carola G. and Hayday, Adrian and Schmack, Katharina},
title = {{The antipsychotic drug clozapine suppresses autoimmunity driving psychosis-like behavior in mice}},
journal = {bioRxiv (preprint)},
year = {2026},
month = mar,
publisher = {bioRxiv},
issn = {2692-8205},
doi = {10.64898/
url = {https://
}
RIS
TY - JOUR
AU - He, Le
AU - Feldman, Harriet
AU - Nguyen, Timothy
AU - Bosc, Marion
AU - Polisetty, Vasishta
AU - Kriel, Orla
AU - Land-wehr, Antonia
AU - Borg, Annabel
AU - Subtil, Fernanda Teixera
AU - Khakpour, Mohammadparsa
AU - Zhou, Jitong
AU - Kjær, Svend
AU - MacCabe, James
AU - Pollak, Thomas A.
AU - Tremblay, Marie-Eve
AU - Vinuesa, Carola G.
AU - Hayday, Adrian
AU - Schmack, Katharina
TI - The antipsychotic drug clozapine suppresses autoimmunity driving psychosis-like behavior in mice
T2 - bioRxiv (preprint)
J2 - bioRxiv
PY - 2026
DA - 2026/
SN - 2692-8205
PB - bioRxiv
DO - 10.64898/
UR - https://
ER -
CSL-JSON
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