OSCR

<i>TMEM106B</i> haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain

Overview

Authors: Alex N. Salazar1, Niccolò Tesi1,2, Sven van der Lee1,3, Frank Koopmans4, Ka Wan Li4, Susan K. Rohde1,5, Maruelle C. Luimes1,5, Annemieke J.M. Rozemuller5, August B. Smit4, Marc Hulsman1, Henne Holstege1,6,7
ORCID iDs: Alex N. Salazar, Sven van der Lee, Henne Holstege
  1. Section Genomics of Neurodegenerative Diseases and Aging, Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
  2. Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands
  3. Amsterdam Neuroscience, Neurodegeneration, Amsterdam, The Netherlands
  4. Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
  5. Department of Pathology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands
  6. VIB Center for Neuroscience, Leuven, Belgium
  7. Department of Neurosciences, Leuven Brain Institute, KU Leuven, Leuven, Belgium
Institutions: Vrije Universiteit Amsterdam (Netherlands); Amsterdam University Medical Centers (Netherlands); Delft University of Technology (Netherlands); Amsterdam Neuroscience (Netherlands); KU Leuven (Belgium)
Journal: medRxiv (preprint)
Dates: published 12 August 2026
Type: Preprint
License: CC BY-ND
Identifiers: DOI 10.64898/2026.08.11.26359568 · OpenAlex W7202276947
Open access: green, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Connectivity, fMRI & imaging
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: Health~Holland (#LSHM20106); ZonMw (LSHM20106, #73305095007, 09150172010083); Technische Universiteit Delft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek (17232, 2022.028, 2025.046, 2024.036, #73305095007, 2020.030, 15318); Alzheimer Nederland (LSHM20106)
Citations: not cited yet (OpenAlex); 40 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.64898/2026.08.11.26359568.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 3, 28 September 2026

  • Authors: added Alex N. Salazar (0000-0002-8453-8769); Sven van der Lee (0000-0003-1606-8643); Henne Holstege (0000-0002-7688-3087); removed Alex N. Salazar; Sven van der Lee; Henne Holstege
  • Funding: added Health~Holland: #LSHM20106; ZonMw: LSHM20106, #73305095007, 09150172010083; Technische Universiteit Delft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek: 17232, 2022.028, 2025.046, 2024.036, #73305095007, 2020.030, 15318; Alzheimer Nederland: LSHM20106

Version 1, 27 September 2026: the first record

Recorded: type, journal, 11 authors, 40 references.

Cite

This paper

Salazar, A. N., Tesi, N., van der Lee, S., Koopmans, F., Li, K. W., Rohde, S. K., Luimes, M. C., Rozemuller, A. J., Smit, A. B., Hulsman, M., & Holstege, H. (2026). <i>TMEM106B</i> haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain. medRxiv (preprint). https://doi.org/10.64898/2026.08.11.26359568

BibTeX

@article{salazar2026i,
author = {Salazar, Alex N. and Tesi, Niccolò and van der Lee, Sven and Koopmans, Frank and Li, Ka Wan and Rohde, Susan K. and Luimes, Maruelle C. and Rozemuller, Annemieke J.M. and Smit, August B. and Hulsman, Marc and Holstege, Henne},
title = {{<i>TMEM106B</i> haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain}},
journal = {medRxiv (preprint)},
year = {2026},
month = aug,
publisher = {medRxiv},
doi = {10.64898/2026.08.11.26359568},
url = {https://doi.org/10.64898/2026.08.11.26359568}
}

RIS

TY - JOUR
AU - Salazar, Alex N.
AU - Tesi, Niccolò
AU - van der Lee, Sven
AU - Koopmans, Frank
AU - Li, Ka Wan
AU - Rohde, Susan K.
AU - Luimes, Maruelle C.
AU - Rozemuller, Annemieke J.M.
AU - Smit, August B.
AU - Hulsman, Marc
AU - Holstege, Henne
TI - <i>TMEM106B</i> haplotypes show distinct associations with tau and TDP-43 pathologies in the aging brain
T2 - medRxiv (preprint)
J2 - medRxiv
PY - 2026
DA - 2026/08/12
PB - medRxiv
DO - 10.64898/2026.08.11.26359568
UR - https://doi.org/10.64898/2026.08.11.26359568
ER -

CSL-JSON

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