PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures.

1. Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE, Lille, France
2. Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
3. Interdisciplinary Institute for Neuroscience, CNRS UMR 5297, University of Bordeaux, Bordeaux, France
4. Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA USA
5. Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, EGID—U1011, Lille, France
6. Genomics of Neurodegenerative Diseases and Aging, Human Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands
7. Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, the Netherlands
8. Amsterdam Neuroscience, Neurodegeneration, Amsterdam, the Netherlands
9. Univ. Rouen Normandie, Inserm U1245 and CHU Rouen, Department of Biostatistics and CNRMAJ, Rouen, France
10. Commissariat à L’Énergie Atomique et Aux Énergies Alternatives, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Gif-sur-Yvette, France
11. Department of Neurology, II B Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
12. Biomedical Research Networking Center on Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain
13. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland
14. Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, University College London Institute of Neurology, London, UK
15. Univ. Rouen Normandie, Inserm U1245 and CHU Rouen, Department of Genetics and CNRMAJ, Rouen, France
16. Medical Research Council Prion Unit, University College London Institute of Prion Diseases, London, UK
17. Department of Cognitive Disorders and Old Age Psychiatry, Medical Faculty, University Hospital Bonn, Bonn, Germany
18. German Center for Neurodegenerative Diseases, Bonn, Germany
19. Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
20. Department of Psychiatry, Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases, UT Health San Antonio, San Antonio, TX USA
21. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Disease (CECAD), University of Cologne, Cologne, Germany
22. Department of Pathology, Kuopio University Hospital, Kuopio, Finland and Unit of Pathology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
23. Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK
24. Department of Neurology, University of Eastern Finland, Kuopio, Finland
25. Department of Neurology, Erasmus Medical Centre, Rotterdam, the Netherlands
26. UK Dementia Research Institute and Moondance Dementia Research Laboratory, Department of Psychological Medicine, Cardiff University, Cardiff, UK
27. Roche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland
28. Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil
29. Bioinformatics Program, Faculty of Computing & Data Sciences, Boston University, Boston, MA USA
30. Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg

@article{coulon2026plcg2,
author = {Coulon, Audrey and Rabiller, Florian and Takalo, Mari and Roy, Avishek and Pelletier, Alexandre and Martiskainen, Henna and Siedlecki-Wullich, Dolores and Lannette-Weimann, Nina and Majerníková, Naďa and Grenon, Arthur and Gao, Vance and Erhardt, Anaël and Pernodet, Anne and Lemaire, Morgane and Limoge, Floriane and Walle, Pauline and Mendes, Tiago and Guyot, Karine and Lemeu, Célia and Carvalho, Lukas-Iohan and Melo de Farias, Ana Raquel and Hulsman, Marc and Najdek, Chloé and Freire-Regatillo, Alejandra and Saha, Orthis and Amouyel, Philippe and Charbonnier, Camille and Deleuze, Jean-François and Dols-Icardo, Orio and Jeskanen, Heli and Willman, Roosa-Maria and Kuulasmaa, Teemu and Kurki, Mitja and Hardy, John and Heikkinen, Sami and Holstege, Henne and Mäkinen, Petra and Nicolas, Gaël and Mead, Simon and Wagner, Michael and Ramirez, Alfredo and Rauramaa, Tuomas and Palotie, Aarno and Sims, Rebecca and Soininen, Hilkka and van Swieten, John and Williams, Julie and Bellenguez, Céline and Gelle, Carla and Lambert, Erwan and Costa, Marcos R and TCW, Julia and Glaab, Enrico and Ayral, Anne-Marie and Demiautte, Florie and Grenier-Boley, Benjamin and Muntaner, Manon and Eberlé, Delphine and Deforges, Séverine and Haas, Joel T and Kilinc, Devrim and Mulle, Christophe and Chapuis, Julien and Hiltunen, Mikko and Dumont, Julie and Lambert, Jean-Charles},
title = {{PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures}},
journal = {Nature genetics},
year = {2026},
month = aug,
volume = {58},
number = {9},
pages = {2164--2176},
publisher = {Nature Portfolio},
issn = {1061-4036},
doi = {10.1038/s41588-026-02709-5},
url = {https://doi.org/10.1038/s41588-026-02709-5},
pmid = {42601455},
pmcid = {PMC13553309}
}

TY - JOUR
AU - Coulon, Audrey
AU - Rabiller, Florian
AU - Takalo, Mari
AU - Roy, Avishek
AU - Pelletier, Alexandre
AU - Martiskainen, Henna
AU - Siedlecki-Wullich, Dolores
AU - Lannette-Weimann, Nina
AU - Majerníková, Naďa
AU - Grenon, Arthur
AU - Gao, Vance
AU - Erhardt, Anaël
AU - Pernodet, Anne
AU - Lemaire, Morgane
AU - Limoge, Floriane
AU - Walle, Pauline
AU - Mendes, Tiago
AU - Guyot, Karine
AU - Lemeu, Célia
AU - Carvalho, Lukas-Iohan
AU - Melo de Farias, Ana Raquel
AU - Hulsman, Marc
AU - Najdek, Chloé
AU - Freire-Regatillo, Alejandra
AU - Saha, Orthis
AU - Amouyel, Philippe
AU - Charbonnier, Camille
AU - Deleuze, Jean-François
AU - Dols-Icardo, Orio
AU - Jeskanen, Heli
AU - Willman, Roosa-Maria
AU - Kuulasmaa, Teemu
AU - Kurki, Mitja
AU - Hardy, John
AU - Heikkinen, Sami
AU - Holstege, Henne
AU - Mäkinen, Petra
AU - Nicolas, Gaël
AU - Mead, Simon
AU - Wagner, Michael
AU - Ramirez, Alfredo
AU - Rauramaa, Tuomas
AU - Palotie, Aarno
AU - Sims, Rebecca
AU - Soininen, Hilkka
AU - van Swieten, John
AU - Williams, Julie
AU - Bellenguez, Céline
AU - Gelle, Carla
AU - Lambert, Erwan
AU - Costa, Marcos R
AU - TCW, Julia
AU - Glaab, Enrico
AU - Ayral, Anne-Marie
AU - Demiautte, Florie
AU - Grenier-Boley, Benjamin
AU - Muntaner, Manon
AU - Eberlé, Delphine
AU - Deforges, Séverine
AU - Haas, Joel T
AU - Kilinc, Devrim
AU - Mulle, Christophe
AU - Chapuis, Julien
AU - Hiltunen, Mikko
AU - Dumont, Julie
AU - Lambert, Jean-Charles
TI - PLCG2 downregulation impairs synaptic function and increases Alzheimer's disease hallmarks in neuronal cultures
T2 - Nature genetics
J2 - Nat Genet
PY - 2026
DA - 2026/08/14
VL - 58
IS - 9
SP - 2164
EP - 2176
SN - 1061-4036
PB - Nature Portfolio
DO - 10.1038/s41588-026-02709-5
UR - https://doi.org/10.1038/s41588-026-02709-5
LA - en
ER -

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