RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle-Brain Communication.
Overview
- Department of Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
- Department of Anesthesiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
- Center For Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
- School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China
- Department of Anesthesiology, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi, China
- Shaanxi Belt and Road Joint Laboratory of Precision Medicine in Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China
- Shaanxi Provincial Key Laboratory of Biological Psychiatry, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Abstract
Anxiety disorders pose a considerable burden on public health. While exercise has been increasingly established as a viable strategy for preventing and alleviating anxiety symptoms, the underlying molecular mechanisms of this action remain elusive. We previously conducted an 8‐week randomized controlled trial which suggested that exercise not only significantly reduced anxiety levels but also triggered the release of acidic ribosomal protein P2 (RPLP2) from peripheral tissues into the bloodstream. These elevated circulating RPLP2 levels showed an inverse association with anxiety severity in patients, suggesting a potential therapeutic role for the protein. Further experiments in mice confirmed that skeletal muscle–derived RPLP2 exerts its anxiolytic effects by facilitating hippocampal neurogenesis. Mechanistically, RPLP2 facilitates ribosomal localization and increases the efficiency of ribosomal subunit assembly, thereby increasing local protein synthesis and supporting the development and maturation of newly generated neurons. The successful maturation of these neurons, in turn, promotes morphological and functional synaptic plasticity, which is crucial for the integration and functional maturation of newborn neurons into hippocampal circuits. Collectively, our findings reveal a previously unknown muscle–brain axis mediated by RPLP2, offering mechanistic evidence for exercise‐induced stress resistance.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Data links
- ncbi.nlm.nih.gov/
geo/ — NCBI; found in “Data Availability Statement”query
Data Availability Statement
The raw proteomics sequence data generated in this study have been submitted to the PRoteomics IDEntifications Database (PRIDE) and are accessible at the following website: https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, pages, dates, 19 authors, 7 keywords, 3 funders, 74 references.
Cite
This paper
Luo, P., Wu, W., Peng, H., He, D., Guo, Y., Zhao, B., Wang, X., Ma, L., Qin, Y., Zhai, Y., Zhuo, L., Zhang, Y., Guo, Y., Jing, L., Chen, F., Zhang, E., Wang, W., Ma, X., & Li, Y. (2026). RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle-Brain Communication. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e76479. https://
BibTeX
@article{luo2026rplp2,
author = {Luo, Peiyu and Wu, Wei and Peng, Huan and He, Dan and Guo, Yuxi and Zhao, Boyue and Wang, Xiaodan and Ma, Li and Qin, Yuhang and Zhai, Yifang and Zhuo, Lixia and Zhang, Ying and Guo, Yijie and Jing, Linlin and Chen, Fangyao and Zhang, Erfei and Wang, Wei and Ma, Xiancang and Li, Yan},
title = {{RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle-Brain Communication}},
journal = {Advanced science (Weinheim, Baden-Wurttemberg, Germany)},
year = {2026},
month = jul,
pages = {e76479},
publisher = {Wiley},
issn = {2198-3844},
doi = {10.1002/
url = {https://
pmid = {42423553},
pmcid = {PMC13348651}
}
RIS
TY - JOUR
AU - Luo, Peiyu
AU - Wu, Wei
AU - Peng, Huan
AU - He, Dan
AU - Guo, Yuxi
AU - Zhao, Boyue
AU - Wang, Xiaodan
AU - Ma, Li
AU - Qin, Yuhang
AU - Zhai, Yifang
AU - Zhuo, Lixia
AU - Zhang, Ying
AU - Guo, Yijie
AU - Jing, Linlin
AU - Chen, Fangyao
AU - Zhang, Erfei
AU - Wang, Wei
AU - Ma, Xiancang
AU - Li, Yan
TI - RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle-Brain Communication
T2 - Advanced science (Weinheim, Baden-Wurttemberg, Germany)
J2 - Adv Sci (Weinh)
PY - 2026
DA - 2026/
SP - e76479
SN - 2198-3844
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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