OSCR

Cognitive reserve and longitudinal changes in brain and cognition in semantic variant primary progressive aphasia.

Overview

Authors: Lauren A. Grebe1,2,3, Brittany T. Morin2,4, Janhavi Pillai2, David Paul Galang Baquirin2, Buddhika Ratnasiri2, Rian Bogley2, Zoe Ezzes2, Lisa D. Wauters2,5, Maria Luisa Mandelli2, Zachary A. Miller2, Boon Lead Tee2, Jessica de Leon2, Kaitlin B. Casaletto2, Howard J. Rosen2, Maria Luisa Gorno Tempini2, Elizabeth E. Galletta6,7, Mira Goral3,8, Jet M. J. Vonk2
  1. Communication Sciences and Disorders St. John's University Jamaica New York USA
  2. Memory and Aging Center, Department of Neurology University of California, San Francisco San Francisco California USA
  3. Speech‐Language‐Hearing Sciences The Graduate Center, City University of New York New York New York USA
  4. Mission Bay Campus University of California, San Francisco San Francisco California USA
  5. Speech, Language, and Hearing Sciences University of Texas at Austin Austin Texas USA
  6. Department of Rehabilitation Medicine NYU Grossman School of Medicine New York New York USA
  7. Communication Sciences & Disorders SUNY, Plattsburgh Plattsburgh New York USA
  8. Speech‐Language‐Hearing Sciences Lehman College Bronx New York USA
Institutions: The Graduate Center, CUNY (United States); St. John's University (United States); City University of New York (United States); University of California, San Francisco (United States); The University of Texas at Austin (United States); State University of New York (United States); New York University (United States); SUNY Plattsburgh (United States); Lehman College (United States)
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association, volume 22, issue 5, article e71440
Dates: received 14 October 2025; accepted 1 April 2026; published online 3 May 2026; in print May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/alz.71440 · PMID 42071171 · PMCID PMC13135915 · OpenAlex W7160090155
Open access: hybrid, a free copy (OpenAlex)
Status: code verified
Categories: structural MRI / diffusion (modality), human (organism), Alzheimer's / dementia (population), cognitive (subfield)
Methods: Statistics
Keywords: cognitive resilience, education, frontotemporal dementia, language, occupation, trajectories
MeSH: Aphasia, Primary Progressive*, Brain*, Cognition*, Cognitive Reserve*, Aged, Disease Progression, Educational Status, Female, Gray Matter, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Semantics (* major topic)
Topic: Neurobiology of Language and Bilingualism (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: Alzheimer's Disease Research Center of California; NIH (NIA R01AG080469, R01AG083840, U19AG079774, P01AG019724 (J.D.L.), U01NS128913, NIDCD K24DC015544 (M.L.G.T.), RF1NS050915 (M.L.G.T.), R01 NS100440‐01, R01AG058233, R01AG080396 (J.D.L.), R01AG075775 (M.L.G.T.)); Alzheimer's Association (AACSFD‐22‐972143); NWO/ZonMw Veni Grant; U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) (R00AG066934)
Citations: not cited yet (Europe PMC); 64 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

jmjvonk

License: none: the authors keep all their rights
State: the link answers, verified on 27 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: the text, “Statistical analyses”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source: github.com/jmjvonk

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
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Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 18 authors, 6 keywords, 16 MeSH terms, 5 funders, 60 references.

Cite

This paper

Grebe, L. A., Morin, B. T., Pillai, J., Baquirin, D. P. G., Ratnasiri, B., Bogley, R., Ezzes, Z., Wauters, L. D., Mandelli, M. L., Miller, Z. A., Tee, B. L., de Leon, J., Casaletto, K. B., Rosen, H. J., Gorno Tempini, M. L., Galletta, E. E., Goral, M., & Vonk, J. M. J. (2026). Cognitive reserve and longitudinal changes in brain and cognition in semantic variant primary progressive aphasia. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(5), e71440. https://doi.org/10.1002/alz.71440

BibTeX

@article{grebe2026cognitive,
author = {Grebe, Lauren A. and Morin, Brittany T. and Pillai, Janhavi and Baquirin, David Paul Galang and Ratnasiri, Buddhika and Bogley, Rian and Ezzes, Zoe and Wauters, Lisa D. and Mandelli, Maria Luisa and Miller, Zachary A. and Tee, Boon Lead and de Leon, Jessica and Casaletto, Kaitlin B. and Rosen, Howard J. and Gorno Tempini, Maria Luisa and Galletta, Elizabeth E. and Goral, Mira and Vonk, Jet M. J.},
title = {{Cognitive reserve and longitudinal changes in brain and cognition in semantic variant primary progressive aphasia}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = may,
volume = {22},
number = {5},
pages = {e71440},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/alz.71440},
url = {https://doi.org/10.1002/alz.71440},
pmid = {42071171},
pmcid = {PMC13135915}
}

RIS

TY - JOUR
AU - Grebe, Lauren A.
AU - Morin, Brittany T.
AU - Pillai, Janhavi
AU - Baquirin, David Paul Galang
AU - Ratnasiri, Buddhika
AU - Bogley, Rian
AU - Ezzes, Zoe
AU - Wauters, Lisa D.
AU - Mandelli, Maria Luisa
AU - Miller, Zachary A.
AU - Tee, Boon Lead
AU - de Leon, Jessica
AU - Casaletto, Kaitlin B.
AU - Rosen, Howard J.
AU - Gorno Tempini, Maria Luisa
AU - Galletta, Elizabeth E.
AU - Goral, Mira
AU - Vonk, Jet M. J.
TI - Cognitive reserve and longitudinal changes in brain and cognition in semantic variant primary progressive aphasia
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/05/01
VL - 22
IS - 5
SP - e71440
SN - 1552-5260
PB - Wiley
DO - 10.1002/alz.71440
UR - https://doi.org/10.1002/alz.71440
LA - en
ER -

CSL-JSON

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