Distinct and shared multimodal neuroimaging patterns in clinical frontotemporal dementia syndromes.
Overview
- Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
- Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
- Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
- Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
Abstract
Clinical syndromes of frontotemporal dementia present both distinct and overlapping neuroimaging abnormalities and, consequently, domains of impairment. The aim of this study was to determine how well covariance patterns from multiple neuroimaging modalities discriminate across clinical frontotemporal dementia syndromes. Four-hundred participants with a clinical frontotemporal dementia diagnosis, including behavioural variant of frontotemporal dementia, semantic variant of primary progressive aphasia, right temporal variant of frontotemporal dementia, primary progressive aphasia, apraxia of speech with agrammatic aphasia, primary progressive apraxia of speech, progressive supranuclear palsy and corticobasal syndrome, and 109 cognitively unimpaired participants underwent extensive neurological and neuropsychological assessments, structural magnetic resonance imaging (MRI), flortaucipir-PET for tau and [18F] fluorodeoxyglucose-PET. Multimodal imaging covariance was investigated at the voxel-level using principal component analysis after adjusting for age and sex effects. Linear regression models were fit to investigate the relationship between principal components and clinical scores. Multinomial logistic regression models were used to investigate the ability of imaging principal components to discriminate across syndromes. The first principal component, which describes the largest source of variability in the data, was a pattern of widespread cortical atrophy (21% variability explained) and of frontoparietal and temporal hypometabolism (21%): scores were lowest in the behavioural variant of frontotemporal dementia and correlated with general cognitive impairment. On tau-PET, the first principal component (43% of variability) did not significantly differ among syndromes and captured a widespread cortical tau uptake, with a focus on the temporal lobe. In all three modalities, the second principal component captured temporal lobe imaging abnormalities, contrasting the motor and semantic clinical syndromes. Subsequent components described smaller variability. In cross-validation, the classifiers based on principal components from MRI (multiclass area under the receiver operating characteristic: 0.76) and [18F]fluorodeoxyglucose-
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data and scripts (R, MATLAB) that support the findings of this study are available from the corresponding author upon reasonable request.
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Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 5 keywords, 2 funders, 77 references.
Cite
This paper
Sintini, I., Singh-Reilly, N., Ali, F., Duffy, J. R., Clark, H. M., Utianski, R. L., Meade, G. F., Machulda, M. M., Satoh, R., Dickson, D. W., Lowe, V. J., Josephs, K. A., & Whitwell, J. L. (2026). Distinct and shared multimodal neuroimaging patterns in clinical frontotemporal dementia syndromes. Brain communications, 8(5), fcag341. https://
BibTeX
@article{sintini2026dist
author = {Sintini, Irene and Singh-Reilly, Neha and Ali, Farwa and Duffy, Joseph R and Clark, Heather M and Utianski, Rene L and Meade, Gabriela F and Machulda, Mary M and Satoh, Ryota and Dickson, Dennis W and Lowe, Val J and Josephs, Keith A and Whitwell, Jennifer L},
title = {{Distinct and shared multimodal neuroimaging patterns in clinical frontotemporal dementia syndromes}},
journal = {Brain communications},
year = {2026},
month = sep,
volume = {8},
number = {5},
pages = {fcag341},
publisher = {Oxford University Press},
issn = {2632-1297},
doi = {10.1093/
url = {https://
pmid = {42756560},
pmcid = {PMC13583894}
}
RIS
TY - JOUR
AU - Sintini, Irene
AU - Singh-Reilly, Neha
AU - Ali, Farwa
AU - Duffy, Joseph R
AU - Clark, Heather M
AU - Utianski, Rene L
AU - Meade, Gabriela F
AU - Machulda, Mary M
AU - Satoh, Ryota
AU - Dickson, Dennis W
AU - Lowe, Val J
AU - Josephs, Keith A
AU - Whitwell, Jennifer L
TI - Distinct and shared multimodal neuroimaging patterns in clinical frontotemporal dementia syndromes
T2 - Brain communications
J2 - Brain Commun
PY - 2026
DA - 2026/
VL - 8
IS - 5
SP - fcag341
SN - 2632-1297
PB - Oxford University Press
DO - 10.1093/
UR - https://
LA - en
ER -
CSL-JSON
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