SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain.
Overview
- Center for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
- Center for Data Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
- Bioinformatics Shared Resource, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
- Proteomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
- NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
- Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
- The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
- Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
Abstract
A role for the trafficking receptor SORLA (Sortilin-related receptor containing LDLR class A repeats) in reducing Aβ levels has been well established; however, relatively little is known with respect to whether and how SORLA can potentially affect tau pathology in vivo. Here, we show that transgenic SORLA up-regulation (SORLA TG) can attenuate pathological effects in aged PS19 (P301S tau) mouse brain, including tau phosphorylation and seeding, ventricle dilation, synapse loss, long-term potentiation (LTP) impairment, and glial hyperactivation. Proteomic analysis indicates attenuation of PS19 profiles in PS19/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- geo:GSE278216 — at NCBI GEO; found in “Data, code, and materials availability:”
Data, code, and materials availability
All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 17 MeSH terms, 6 funders, 118 references.
Cite
This paper
Huang, H., Shi, C. H., Yang, W., Piña-Crespo, J. C., Bhatnagar, J., Curatolo, J., Murad, R., Shah, P., Campos, A., Houser, A., Porritt, R. A., Van Vo, G., Xiao, Q., Zhang, T., Feng, S., Yip, K. Y., & Huang, T. Y. (2026). SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain. Science advances, 12(29), eaed6825. https://
BibTeX
@article{huang2026sorla,
author = {Huang, Huijie and Shi, Christina Huan and Yang, Wenqi and Piña-Crespo, Juan C and Bhatnagar, Jay and Curatolo, Julian and Murad, Rabi and Shah, Palak and Campos, Alex and Houser, Alexandra and Porritt, Rebecca A and Van Vo, Giau and Xiao, Qiang and Zhang, Tongmei and Feng, Shengjie and Yip, Kevin Y and Huang, Timothy Y},
title = {{SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain}},
journal = {Science advances},
year = {2026},
month = jul,
volume = {12},
number = {29},
pages = {eaed6825},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/
url = {https://
pmid = {42467771},
pmcid = {PMC13378584}
}
RIS
TY - JOUR
AU - Huang, Huijie
AU - Shi, Christina Huan
AU - Yang, Wenqi
AU - Piña-Crespo, Juan C
AU - Bhatnagar, Jay
AU - Curatolo, Julian
AU - Murad, Rabi
AU - Shah, Palak
AU - Campos, Alex
AU - Houser, Alexandra
AU - Porritt, Rebecca A
AU - Van Vo, Giau
AU - Xiao, Qiang
AU - Zhang, Tongmei
AU - Feng, Shengjie
AU - Yip, Kevin Y
AU - Huang, Timothy Y
TI - SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/
VL - 12
IS - 29
SP - eaed6825
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/
UR - https://
LA - en
ER -
CSL-JSON
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