SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain.
Overview
- Center for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
- Center for Data Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
- Bioinformatics Shared Resource, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
- Proteomics Core Facility, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
- NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
- Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
- The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
- Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA
Abstract
A role for the trafficking receptor SORLA (Sortilin-related receptor containing LDLR class A repeats) in reducing Aβ levels has been well established; however, relatively little is known with respect to whether and how SORLA can potentially affect tau pathology in vivo. Here, we show that transgenic SORLA up-regulation (SORLA TG) can attenuate pathological effects in aged PS19 (P301S tau) mouse brain, including tau phosphorylation and seeding, ventricle dilation, synapse loss, long-term potentiation (LTP) impairment, and glial hyperactivation. Proteomic analysis indicates attenuation of PS19 profiles in PS19/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- geo:GSE278216, at NCBI GEO; found in “Data, code, and materials availability:”
Data, code, and materials availability
All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/
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Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 17 MeSH terms, 6 funders, 118 references.
Cite
This paper
Huang, H., Shi, C. H., Yang, W., Piña-Crespo, J. C., Bhatnagar, J., Curatolo, J., Murad, R., Shah, P., Campos, A., Houser, A., Porritt, R. A., Van Vo, G., Xiao, Q., Zhang, T., Feng, S., Yip, K. Y., & Huang, T. Y. (2026). SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain. Science advances, 12(29), eaed6825. https://
BibTeX
@article{huang2026sorla,
author = {Huang, Huijie and Shi, Christina Huan and Yang, Wenqi and Piña-Crespo, Juan C and Bhatnagar, Jay and Curatolo, Julian and Murad, Rabi and Shah, Palak and Campos, Alex and Houser, Alexandra and Porritt, Rebecca A and Van Vo, Giau and Xiao, Qiang and Zhang, Tongmei and Feng, Shengjie and Yip, Kevin Y and Huang, Timothy Y},
title = {{SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain}},
journal = {Science advances},
year = {2026},
month = jul,
volume = {12},
number = {29},
pages = {eaed6825},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/
url = {https://
pmid = {42467771},
pmcid = {PMC13378584}
}
RIS
TY - JOUR
AU - Huang, Huijie
AU - Shi, Christina Huan
AU - Yang, Wenqi
AU - Piña-Crespo, Juan C
AU - Bhatnagar, Jay
AU - Curatolo, Julian
AU - Murad, Rabi
AU - Shah, Palak
AU - Campos, Alex
AU - Houser, Alexandra
AU - Porritt, Rebecca A
AU - Van Vo, Giau
AU - Xiao, Qiang
AU - Zhang, Tongmei
AU - Feng, Shengjie
AU - Yip, Kevin Y
AU - Huang, Timothy Y
TI - SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/
VL - 12
IS - 29
SP - eaed6825
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/
UR - https://
LA - en
ER -
CSL-JSON
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