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Longitudinal effects of physical activity on sleep in association with hippocampal-amygdala subfield structure and functional connectivity in Alzheimer's disease.

Overview

Authors: Ravi Dadsena1,2, Ana S. Costa1,2, Shari David1, Luisa Haberl1, Jörg B. Schulz1,2, Kathrin Reetz1,2, Alexa Haeger1,2
ORCID iDs: Ravi Dadsena, Ana S. Costa
  1. Centre for Dementia and Prevention Aachen (ZDPA) Department of Neurology RWTH Aachen University Aachen Germany
  2. JARA Brain Institute Translational Neuroscience Research Centre Jülich and RWTH Aachen University Aachen Germany
Institutions: Jülich Aachen Research Alliance (Germany); RWTH Aachen University (Germany)
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association, volume 22, issue 8, article e71651
Dates: received 2 March 2026; accepted 6 June 2026; published online 25 August 2026; in print August 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1002/alz.71651 · PMID 42638617 · PMCID PMC13504447 · OpenAlex W7204185505
Open access: hybrid, a free copy (OpenAlex)
Status: code on request
Categories: structural MRI / diffusion (modality), fMRI (modality), human (organism), Alzheimer's / dementia (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Statistics, Smoothing, state filtering, decompositions, Connectivity, fMRI & imaging, Machine learning
Keywords: Alzheimer's disease, cognitive decline, functional connectivity, medial temporal lobe subfields, neurodegeneration, neuroimaging, physical activity intervention, resting state, sleep
MeSH: Alzheimer Disease*, Amygdala*, Exercise*, Hippocampus*, Sleep*, Aged, Aged, 80 and over, Atrophy, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests (* major topic)
Topic: Dementia and Cognitive Impairment Research (Psychiatry and Mental health, Medicine), according to OpenAlex
Funding: RWTH‐Startup Grant from the Exploratory Research Space – ERS, RWTH Aachen University (StUpPD_329‐18); Rotation Program and Short Term Program of the Faculty of Medicine, RWTH Aachen University; Stiftung Universitätsmedizin Aachen; IRTG Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) (269953372/GRK2150)
Citations: not cited yet (Europe PMC); 87 references in the paper

Abstract

INTRODUCTION: Sleep is a modifiable risk factor in Alzheimer's disease (AD), but its relationship to medial temporal lobe (MTL) subfields and responsiveness to lifestyle interventions remain unclear.

METHODS: In the Dementia‐Multi‐Objective Validation of Exercise (MOVE) study, 46 individuals on the AD continuum were randomized to 6 months of multimodal exercise (n = 25) or psychoeducation (n = 21) and followed for 18 months (T1–T4). Clinical and cognitive testing, sleep/activity measures (PSQI, diaries, wearables), high‐resolution T1, and resting‐state functional magnetic resonance imaging scans were acquired. Hippocampal and amygdala subfield volumes and hippocampus−amygdala connectivity were analyzed longitudinally.

RESULTS: After the 6‐month intervention, the intervention group showed increased hippocampus–amygdala connectivity and attenuated subfield atrophy. One year later, both groups progressed in cognitive decline and hippocampal atrophy. Hippocampal and amygdalar volumes and connectivity were associated with sleep parameters as well as activity and cognitive parameters.

DISCUSSION: Exercise was associated with short‐term MTL preservation and network reorganization linked to sleep and activity, supporting continuous physical activity for lasting benefits.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

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Data

No dataset and no data link were found in the paper.

Data availability statement

De‐identified study data and the analysis code used in this study are available from the corresponding author on reasonable request, subject to institutional and data protection regulations.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 9 keywords, 15 MeSH terms, 4 funders, 82 references.

Cite

This paper

Dadsena, R., Costa, A. S., David, S., Haberl, L., Schulz, J. B., Reetz, K., & Haeger, A. (2026). Longitudinal effects of physical activity on sleep in association with hippocampal-amygdala subfield structure and functional connectivity in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(8), e71651. https://doi.org/10.1002/alz.71651

BibTeX

@article{dadsena2026longitudinal,
author = {Dadsena, Ravi and Costa, Ana S. and David, Shari and Haberl, Luisa and Schulz, Jörg B. and Reetz, Kathrin and Haeger, Alexa},
title = {{Longitudinal effects of physical activity on sleep in association with hippocampal-amygdala subfield structure and functional connectivity in Alzheimer's disease}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = aug,
volume = {22},
number = {8},
pages = {e71651},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/alz.71651},
url = {https://doi.org/10.1002/alz.71651},
pmid = {42638617},
pmcid = {PMC13504447}
}

RIS

TY - JOUR
AU - Dadsena, Ravi
AU - Costa, Ana S.
AU - David, Shari
AU - Haberl, Luisa
AU - Schulz, Jörg B.
AU - Reetz, Kathrin
AU - Haeger, Alexa
TI - Longitudinal effects of physical activity on sleep in association with hippocampal-amygdala subfield structure and functional connectivity in Alzheimer's disease
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/08/01
VL - 22
IS - 8
SP - e71651
SN - 1552-5260
PB - Wiley
DO - 10.1002/alz.71651
UR - https://doi.org/10.1002/alz.71651
LA - en
ER -

CSL-JSON

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