Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum.
Overview
- Department of Radiology China‐Japan Friendship Hospital Beijing China
- Peking University China‐Japan Friendship School of Clinical Medicine Beijing China
- Department of Radiology MRI Research Institute (MRIRI) Weill Cornell Medicine New York New York USA
- State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing China
- Department of Neurology China‐Japan Friendship Hospital Beijing China
- Department of Nuclear Medicine, China‐Japan Friendship Hospital Beijing China
- Department of Radiology Brain Health Imaging Institute (BHII) Weill Cornell Medicine New York New York USA
Abstract
INTRODUCTION: We tested whether quantitative transport mapping (QTM)‐derived perfusion velocity would detect earlier and more sex‐specific microvascular alterations than cerebral blood flow (CBF) across the Alzheimer's disease (AD) continuum.
METHODS: In 182 participants (cognitively normal = 53, subjective cognitive decline [SCD] = 48, mild cognitive impairment [MCI] = 31, AD = 50), seven‐delay arterial spin labeling was used to derive CBF and QTM velocity. Age/
RESULTS: QTM velocity was reduced already in SCD, including the hippocampus, whereas CBF declined mainly in MCI/
DISCUSSION: QTM is a non‐invasive biomarker more sensitive than CBF to early, female‐biased microvascular transport dysfunction in AD.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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The raw data and analytical code that support the findings of this study are available on request from the corresponding author.
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 8 keywords, 14 MeSH terms, 4 funders, 65 references.
Cite
This paper
Xu, M., Gao, Y., Ou, P., Yang, H., Wang, J., Liu, W., Shu, N., Sun, Y., Fu, L., Glodzik, L., Butler, T. A., Chaing, G. C., Li, Y., Wang, Y., Zhou, L., & Ma, G. (2026). Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(9), e71811. https://
BibTeX
@article{xu2026female,
author = {Xu, Manxi and Gao, Yian and Ou, Peiling and Yang, Haoyu and Wang, Jia and Liu, Wulong and Shu, Ni and Sun, Yu and Fu, Liping and Glodzik, Lidia and Butler, Tracy A and Chaing, Gloria C and Li, Yi and Wang, Yi and Zhou, Liangdong and Ma, Guolin},
title = {{Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = sep,
volume = {22},
number = {9},
pages = {e71811},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/
url = {https://
pmid = {42675347},
pmcid = {PMC13529826}
}
RIS
TY - JOUR
AU - Xu, Manxi
AU - Gao, Yian
AU - Ou, Peiling
AU - Yang, Haoyu
AU - Wang, Jia
AU - Liu, Wulong
AU - Shu, Ni
AU - Sun, Yu
AU - Fu, Liping
AU - Glodzik, Lidia
AU - Butler, Tracy A
AU - Chaing, Gloria C
AU - Li, Yi
AU - Wang, Yi
AU - Zhou, Liangdong
AU - Ma, Guolin
TI - Female vulnerability to microvascular transport dysfunction emerges early across the Alzheimer's disease continuum
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/
VL - 22
IS - 9
SP - e71811
SN - 1552-5260
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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