OSCR

Diffusion MRI and α-Synuclein Seed Amplification Status in Parkinson's Disease.

Overview

Authors: Shannon Y. Chiu1, Wei‐en Wang2, Robin Chen2, Jesse C. DeSimone2, Derek B. Archer3,4, Charles H. Adler1, Shyamal H. Mehta1, Sara R. Dresler1, Melissa J. Armstrong5, Nikolaus McFarland5, Michael Okun5, David E. Vaillancourt2, Parkinson's Progression Markers Initiative
  1. Department of Neurology Mayo Clinic College of Medicine Scottsdale AZ
  2. Department of Applied Physiology and Kinesiology University of Florida Gainesville FL
  3. Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center Nashville TN
  4. Vanderbilt Brain Institute, Vanderbilt University Nashville TN
  5. Norman Fixel Institute for Neurological Diseases, Department of Neurology University of Florida Gainesville FL
Institutions: Mayo Clinic (United States); Mayo Clinic in Arizona (United States); University of Florida (United States); Vanderbilt University (United States); Vanderbilt University Medical Center (United States); University of Florida Health (United States)
Journal: Annals of neurology, volume 100, issue 2, pages 295-304
Dates: received 12 June 2025; accepted 13 April 2026; published online 7 May 2026; in print August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/ana.78252 · PMID 42095555 · PMCID PMC13387916 · OpenAlex W7160517361
Open access: hybrid, a free copy (OpenAlex)
Status: code verified
Categories: structural MRI / diffusion (modality), human (organism), Parkinson's (population), clinical / translational (subfield)
Methods: Statistics, fMRI & imaging
MeSH: alpha-Synuclein*, Brain*, Diffusion Magnetic Resonance Imaging*, Parkinson Disease*, Aged, Female, Humans, Male, Middle Aged (* major topic)
Topic: Parkinson's Disease Mechanisms and Treatments (Neurology, Medicine), according to OpenAlex
Funding: NIA NIH HHS (K01 AG073584, P30 AG066506, K23 AG073525); NINDS NIH HHS (R01 NS058487, R01 NS075012, T32 NS082168, U01 NS119562)
Citations: cited by 1 paper (Europe PMC); 46 references in the paper
Research resources: RRID:SCR_006431

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

stnava.github.io

License: none: the authors keep all their rights
State: the link answers, verified on 28 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: the text, “dMRI Analysis”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 28 September 2026: the link answers (HTTP 200)
  • 28 September 2026: the link answers (HTTP 200)
At the source: stnava.github.io

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request

Read it in the paper: doi.org/10.1002/ana.78252.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: — → Wiley

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 9 MeSH terms, 2 funders, 39 references, 1 RRID.

Cite

This paper

Chiu, S. Y., Wang, W., Chen, R., DeSimone, J. C., Archer, D. B., Adler, C. H., Mehta, S. H., Dresler, S. R., Armstrong, M. J., McFarland, N., Okun, M., Vaillancourt, D. E., & Parkinson's Progression Markers Initiative. (2026). Diffusion MRI and α-Synuclein Seed Amplification Status in Parkinson's Disease. Annals of neurology, 100(2), 295-304. https://doi.org/10.1002/ana.78252

BibTeX

@article{chiu2026diffusion,
author = {Chiu, Shannon Y. and Wang, Wei‐en and Chen, Robin and DeSimone, Jesse C. and Archer, Derek B. and Adler, Charles H. and Mehta, Shyamal H. and Dresler, Sara R. and Armstrong, Melissa J. and McFarland, Nikolaus and Okun, Michael and Vaillancourt, David E. and {Parkinson's Progression Markers Initiative}},
title = {{Diffusion MRI and α-Synuclein Seed Amplification Status in Parkinson's Disease}},
journal = {Annals of neurology},
year = {2026},
month = may,
volume = {100},
number = {2},
pages = {295--304},
publisher = {Wiley},
issn = {0364-5134},
doi = {10.1002/ana.78252},
url = {https://doi.org/10.1002/ana.78252},
pmid = {42095555},
pmcid = {PMC13387916}
}

RIS

TY - JOUR
AU - Chiu, Shannon Y.
AU - Wang, Wei‐en
AU - Chen, Robin
AU - DeSimone, Jesse C.
AU - Archer, Derek B.
AU - Adler, Charles H.
AU - Mehta, Shyamal H.
AU - Dresler, Sara R.
AU - Armstrong, Melissa J.
AU - McFarland, Nikolaus
AU - Okun, Michael
AU - Vaillancourt, David E.
AU - Parkinson's Progression Markers Initiative
TI - Diffusion MRI and α-Synuclein Seed Amplification Status in Parkinson's Disease
T2 - Annals of neurology
J2 - Ann Neurol
PY - 2026
DA - 2026/05/07
VL - 100
IS - 2
SP - 295
EP - 304
SN - 0364-5134
PB - Wiley
DO - 10.1002/ana.78252
UR - https://doi.org/10.1002/ana.78252
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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