Structural Volumetric Alterations in Parkinson's Disease With Mild Cognitive Impairment.
Overview
- Department of Radiology Affiliated Hospital of Youjiang Medical University for Nationalities Baise China
- School of Medical Laboratory Science Affiliated Hospital of Youjiang Medical University for Nationalities Baise China
- Guangxi Engineering Research Center for Precise Genetic Testing of Long‐dwelling Nationalities, Guangxi, China Baise China
Abstract
Background: Parkinson's disease with mild cognitive impairment (PD‐MCI) is a critical dementia prodrome, but its structural neuropathology remains incompletely defined. While hippocampal atrophy is established, volumetric changes in other subcortical structures are poorly characterized.
Objective: To perform the first comprehensive meta‐analysis quantifying gray matter volume alterations across six subcortical regions in PD‐MCI.
Methods: A systematic search of PubMed, Web of Science, Embase, and Cochrane (inception‐June 2025) for studies reporting MRI volumetric data comparing PD‐MCI and cognitively normal PD (PD‐NC) was done. Random‐effects models calculated pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs). Heterogeneity (I 2), publication bias, sensitivity analyses, and meta‐regression were assessed.
Results: PD‐MCI showed significant bilateral atrophy versus PD‐NC in the hippocampus (total WMD = –0.65 cm3), thalamus, putamen, and amygdala, alongside right‐lateralized globus pallidus atrophy (WMD = –0.08 cm3). Bilateral caudate nuclei volumes were preserved. Sensitivity analyses confirmed robustness. Meta‐regression identified segmentation tools and country as sources of left hippocampal heterogeneity (p < 0.05). No publication bias was detected.
Conclusion: PD‐MCI exhibits a distinct subcortical atrophy signature involving limbic–striato‐thalamic networks, with right globus pallidus atrophy as a novel lateralized biomarker. Network‐based imaging paradigms are advocated, requiring standardized protocols and longitudinal validation.
Systematic Review Registration: Identifier PROSPERO (CRD420251051275).
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
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Data Availability Statement
The data supporting this meta‐analysis are available from the published articles cited in the manuscript. Extracted datasets and analysis scripts can be obtained from the corresponding author upon reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 5 keywords, 11 MeSH terms, 2 funders, 46 references.
Cite
This paper
Hu, J., Lei, P., Zhang, J., Wu, Q., Zhang, Z., Zhu, X., & Li, B. (2026). Structural Volumetric Alterations in Parkinson's Disease With Mild Cognitive Impairment. Brain and behavior, 16(5), e71410. https://
BibTeX
@article{hu2026structura
author = {Hu, Jinhua and Lei, Peng and Zhang, Jupeng and Wu, Qi and Zhang, Zhihao and Zhu, Xiqi and Li, Baosheng},
title = {{Structural Volumetric Alterations in Parkinson's Disease With Mild Cognitive Impairment}},
journal = {Brain and behavior},
year = {2026},
month = may,
volume = {16},
number = {5},
pages = {e71410},
publisher = {Wiley},
issn = {2162-3279},
doi = {10.1002/
url = {https://
pmid = {42043968},
pmcid = {PMC13118392}
}
RIS
TY - JOUR
AU - Hu, Jinhua
AU - Lei, Peng
AU - Zhang, Jupeng
AU - Wu, Qi
AU - Zhang, Zhihao
AU - Zhu, Xiqi
AU - Li, Baosheng
TI - Structural Volumetric Alterations in Parkinson's Disease With Mild Cognitive Impairment
T2 - Brain and behavior
J2 - Brain Behav
PY - 2026
DA - 2026/
VL - 16
IS - 5
SP - e71410
SN - 2162-3279
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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