OSCR

The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities.

Overview

Authors: Fengshou Chen1, Limei Wang1, Hao Liu2, Qasim Khan3, Bing Tang1, Naren Bao1
  1. Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, Liaoning China
  2. Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning China
  3. Schulich School of Engineering, University of Calgary, Calgary, T2N 1N4 Canada
Journal: Journal of nanobiotechnology, volume 24, issue 1, article 790
Dates: received 14 January 2026; accepted 7 May 2026; published online 10 July 2026
Type: Review · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12951-026-04551-7 · PMID 42432671 · PMCID PMC13491992 · OpenAlex W7167828523
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), other condition (population), Alzheimer's / dementia (population), Parkinson's (population), multiple sclerosis (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning
Keywords: Neurological Disorders, Alzheimer’s Disease, Parkinson’s Disease, Multiple Sclerosis, Artificial Intelligence, Drug Repurposing
MeSH: Artificial Intelligence*, Drug Repositioning*, Nervous System Diseases*, Animals, Blood-Brain Barrier, Humans, Neurodegenerative Diseases (* major topic)
Topic: Artificial Intelligence in Healthcare and Education (Health Informatics, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 364 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1186/s12951-026-04551-7.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 6 keywords, 7 MeSH terms, 345 references.

Cite

This paper

Chen, F., Wang, L., Liu, H., Khan, Q., Tang, B., & Bao, N. (2026). The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities. Journal of nanobiotechnology, 24(1), 790. https://doi.org/10.1186/s12951-026-04551-7

BibTeX

@article{chen2026role,
author = {Chen, Fengshou and Wang, Limei and Liu, Hao and Khan, Qasim and Tang, Bing and Bao, Naren},
title = {{The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities}},
journal = {Journal of nanobiotechnology},
year = {2026},
month = jul,
volume = {24},
number = {1},
pages = {790},
publisher = {BMC},
issn = {1477-3155},
doi = {10.1186/s12951-026-04551-7},
url = {https://doi.org/10.1186/s12951-026-04551-7},
pmid = {42432671},
pmcid = {PMC13491992}
}

RIS

TY - JOUR
AU - Chen, Fengshou
AU - Wang, Limei
AU - Liu, Hao
AU - Khan, Qasim
AU - Tang, Bing
AU - Bao, Naren
TI - The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities
T2 - Journal of nanobiotechnology
J2 - J Nanobiotechnology
PY - 2026
DA - 2026/07/10
VL - 24
IS - 1
SP - 790
SN - 1477-3155
PB - BMC
DO - 10.1186/s12951-026-04551-7
UR - https://doi.org/10.1186/s12951-026-04551-7
LA - en
ER -

CSL-JSON

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{
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"volume": "24",
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"PMCID": "PMC13491992",
"ISSN": "1477-3155",
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"language": "en",
"issued": {
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}

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