The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities.
Overview
- Department of Anesthesiology, The First Hospital of China Medical University, Shenyang, Liaoning China
- Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning China
- Schulich School of Engineering, University of Calgary, Calgary, T2N 1N4 Canada
Abstract
The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.
Code
The paper links to its data, not to its authors' code: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Datasets cited
- geo:GSE16561, at NCBI GEO; found in the resources table
Data availability statement
The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:
- no repository, dataset or request procedure was recognized in it
Read it in the paper: doi.org/10.1186/s12951-026-04551-7.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 6 keywords, 7 MeSH terms, 345 references.
Cite
This paper
Chen, F., Wang, L., Liu, H., Khan, Q., Tang, B., & Bao, N. (2026). The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities. Journal of nanobiotechnology, 24(1), 790. https://
BibTeX
@article{chen2026role,
author = {Chen, Fengshou and Wang, Limei and Liu, Hao and Khan, Qasim and Tang, Bing and Bao, Naren},
title = {{The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities}},
journal = {Journal of nanobiotechnology},
year = {2026},
month = jul,
volume = {24},
number = {1},
pages = {790},
publisher = {BMC},
issn = {1477-3155},
doi = {10.1186/
url = {https://
pmid = {42432671},
pmcid = {PMC13491992}
}
RIS
TY - JOUR
AU - Chen, Fengshou
AU - Wang, Limei
AU - Liu, Hao
AU - Khan, Qasim
AU - Tang, Bing
AU - Bao, Naren
TI - The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities
T2 - Journal of nanobiotechnology
J2 - J Nanobiotechnology
PY - 2026
DA - 2026/
VL - 24
IS - 1
SP - 790
SN - 1477-3155
PB - BMC
DO - 10.1186/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1186/
"type": "article-journal",
"title": "The role of AI-assisted drug repurposing in neurological disorders: a systematic review of validation strategies, challenges and opportunities",
"container-title": "Journal of nanobiotechnology",
"author": [
{
"family": "Chen",
"given": "Fengshou"
},
{
"family": "Wang",
"given": "Limei"
},
{
"family": "Liu",
"given": "Hao"
},
{
"family": "Khan",
"given": "Qasim"
},
{
"family": "Tang",
"given": "Bing"
},
{
"family": "Bao",
"given": "Naren"
}
],
"container-title-short":
"volume": "24",
"issue": "1",
"page": "790",
"DOI": "10.1186/
"PMID": "42432671",
"PMCID": "PMC13491992",
"ISSN": "1477-3155",
"publisher": "BMC",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
7,
10
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1038/s44321-026-00473-x
- OTUB1 non-canonically inhibits TAB2 ubiquitination to govern microglia-mediated neuroinflammation.Journal: EMBO molecular medicineIn common: NCBI GEO GSE16561, 2 references
- [2] doi:10.3389/fphar.2026.1870571
- Tissue-autonomous pharmacological direction: how target expression landscapes convert balanced compounds into tissue-selective agents.Journal: Frontiers in pharmacologyIn common: NCBI GEO GSE16561, 1 reference
- [3] doi:10.3389/fmolb.2026.1844734
- Discovery and validation of programmed cell death-associated key biomarker genes in ischemic stroke via ssGSEA/
WGCNA and LASSO-SVM-RFE. Journal: Frontiers in molecular biosciencesIn common: NCBI GEO GSE16561, 1 reference - [4] doi:10.1038/s41598-026-50523-0 [code]
- Mechanistic multiscale modeling identifies putative natural tri-target candidates of MAO-B, LRRK2 and A₂A for Parkinson's disease.Journal: Scientific reportsIn common: Parkinson's, 3 references
- [5] doi:10.21203/rs.3.rs-9060414/v1 [code]
- Cross-Species Aging Knowledge Integration into Agentic AI Platform Uncovers Conserved MechanismsJournal: Research Square (preprint)In common: Alzheimer's / dementia, 3 references
- [6] doi:10.1093/bioinformatics/btag553 [code]
- Spatial-spectral fusion enables drug repositioning by capturing indirect and long-range associations in biological networks.Journal: Bioinformatics (Oxford, England)In common: Parkinson's, Alzheimer's / dementia, 2 references
- [7] doi:10.1007/s10571-026-01710-0
- The Role and Diagnostic Efficacy of the METTL14/
GADD45B m& lt;sup& gt;6& lt;/ sup& gt;A Methylation/ BDNF Regulatory Axis in Acute Ischemic Stroke. Journal: Cellular and molecular neurobiologyIn common: NCBI GEO GSE16561 - [8] doi:10.1101/gr.281113.125 [code]
- Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease.Journal: Genome researchIn common: Parkinson's, 3 references
- [9] doi:10.1002/jnr.70130
- Pantothenic Acid Protects Neurons After Ischemic Stroke by Targeting ID3 to Restore Action Potential Amplitude.Journal: Journal of neuroscience researchIn common: NCBI GEO GSE16561
- [10] doi:10.1007/s00401-026-03039-w [code]
- Correlative ultrastructural mapping of Lewy pathology reveals regional diversity in Parkinson's and dementia with Lewy bodies.Journal: Acta neuropathologicaIn common: Parkinson's, Alzheimer's / dementia, 2 references
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.
