Neuroglial Response to High-Amplitude, Short-Duration Pressure Transients in Monoculture.
Overview
- Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA
- Vanderbilt Biophotonics Center, Vanderbilt University, Nashville, Tennessee, USA
- Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Abstract
Blast‐induced traumatic brain injury (bTBI) was reported in 125,000 U.S. service men and women from 2000 to 2018. With no prophylactic treatments having been granted FDA approval, there is a clear need for further understanding of the impact of blasts on the central nervous system. The biological response of brain cells due to the near‐instantaneous overpressure of blast onset remains unresolved. Laser‐induced pressures isolate high‐amplitude, short‐duration pressure transients, similar to the initial peak of blast pressures. In this study, we uncover the effects of high‐amplitude, short‐duration pressure transients on monocultures of astrocytes, microglia, and neurons through intracellular calcium imaging, cell viability assays, and quantifying intracellular and extracellular immune signaling proteins. The results indicate that while all three cell types follow a similar activation curve for induced intracellular calcium transients, the downstream impact of high‐amplitude, short‐duration pressures on neurons and glia deviate. Neurons are particularly susceptible to non‐reversible damage, while glia activates traditionally neuroprotective pathways rather than neurodegenerative pathways in response to high‐amplitude, short‐duration pressures. This work has important implications for developing countermeasures for bTBI with either the high‐frequency component of a blast wave or the effects of that component being potential targets for prevention.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 2, 28 September 2026
- Publisher: — → Wiley
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 4 keywords, 12 MeSH terms, 1 funder, 51 references.
Cite
This paper
Jenkins, J. L., Rasiah, P. K., Hardenburger, J., Adams, W., Mahadevan‐Jansen, A., Millis, B., & Jansen, E. D. (2026). Neuroglial Response to High-Amplitude, Short-Duration Pressure Transients in Monoculture. Cell biochemistry and function, 44(5), e70231. https://
BibTeX
@article{jenkins2026neur
author = {Jenkins, J Logan and Rasiah, Pratheepa Kumari and Hardenburger, Jacob and Adams, Wilson and Mahadevan‐Jansen, Anita and Millis, Bryan and Jansen, E Duco},
title = {{Neuroglial Response to High-Amplitude, Short-Duration Pressure Transients in Monoculture}},
journal = {Cell biochemistry and function},
year = {2026},
month = may,
volume = {44},
number = {5},
pages = {e70231},
publisher = {Wiley},
issn = {0263-6484},
doi = {10.1002/
url = {https://
pmid = {42117196},
pmcid = {PMC13162088}
}
RIS
TY - JOUR
AU - Jenkins, J Logan
AU - Rasiah, Pratheepa Kumari
AU - Hardenburger, Jacob
AU - Adams, Wilson
AU - Mahadevan‐Jansen, Anita
AU - Millis, Bryan
AU - Jansen, E Duco
TI - Neuroglial Response to High-Amplitude, Short-Duration Pressure Transients in Monoculture
T2 - Cell biochemistry and function
J2 - Cell Biochem Funct
PY - 2026
DA - 2026/
VL - 44
IS - 5
SP - e70231
SN - 0263-6484
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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