The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling.
Overview
Abstract
This study aims to elucidate the role of suppressor of cytokine signaling 3 (SOCS3) in glioma stem cells (GSCs) via single‐cell RNA sequencing (scRNA‐seq), focusing on its regulation of STAT3‐mediated self‐renewal, apoptosis resistance, and tumor microenvironment (TME) remodeling. ScRNA‐seq data from 19 high‐grade glioma patients were analyzed using Seurat, Harmony, and SingleR for clustering, annotation, and SOCS3 stratification (SOCS3‐High: n = 4; SOCS3‐Low: n = 15). Differential gene analysis, pathway enrichment, and CellChat were employed for TME characterization. In vitro, SOCS3‐overexpressing/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- geo:GSE231859 — at NCBI GEO; found in the text, “Download of public datasets”
Data availability statement
All data can be provided as needed.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 6 keywords, 54 references.
Cite
This paper
Wang, J., Hou, G., Song, Z., Gao, K., Wang, H., & Li, T. (2026). The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling. Journal of cell communication and signaling, 20(3), e70041. https://
BibTeX
@article{wang2026suppres
author = {Wang, Jingtao and Hou, Gaolei and Song, Zhaofei and Gao, Kai and Wang, Hongbin and Li, Tao},
title = {{The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling}},
journal = {Journal of cell communication and signaling},
year = {2026},
month = aug,
volume = {20},
number = {3},
pages = {e70041},
publisher = {Wiley},
issn = {1873-9601},
doi = {10.1002/
url = {https://
pmid = {42542877},
pmcid = {PMC13428608}
}
RIS
TY - JOUR
AU - Wang, Jingtao
AU - Hou, Gaolei
AU - Song, Zhaofei
AU - Gao, Kai
AU - Wang, Hongbin
AU - Li, Tao
TI - The suppressor of cytokine signaling 3 regulates glioma stem cell maintenance and immune microenvironment through signal transducer and activator of transcription 3 signaling
T2 - Journal of cell communication and signaling
J2 - J Cell Commun Signal
PY - 2026
DA - 2026/
VL - 20
IS - 3
SP - e70041
SN - 1873-9601
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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