Pantothenic Acid Protects Neurons After Ischemic Stroke by Targeting ID3 to Restore Action Potential Amplitude.
Overview
- Department of Neurology, The First Affiliated Hospital of Guangxi University of Science and Technology, Liuzhou City, Guangxi Zhuang Autonomous Region, China
- Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning City, Guangxi Zhuang Autonomous Region, China
Abstract
Ischemic stroke (IS) remains a devastating condition with limited neuroprotective options. This study investigated the role of the transcription factor inhibitor of DNA binding 3 (ID3) in acute IS through an integrated approach. Combining bioinformatic analysis of Gene Expression Omnibus (GEO) datasets with machine learning (ML) algorithms, we identified ID3 as a consistently downregulated key gene, and its expression level correlated with neurological severity. Functional analysis suggested ID3 modulates neuroinflammation. Furthermore, ID3 and C‐type lectin domain family 4 member E (CLEC4E) showed potential as diagnostic biomarkers. Using network pharmacology, pantothenic acid (PA) was predicted as a potential ID3‐targeting drug. This was preliminarily tested in an oxygen–glucose deprivation/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- geo:GSE16561, at NCBI GEO; found in “Data Availability Statement”
Data Availability Statement
The publicly available datasets (GSE16561 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 2, 28 September 2026
- Publisher: n/a → Wiley
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 5 keywords, 8 MeSH terms, 1 funder, 40 references.
Cite
This paper
Chen, H., Chen, M., Meng, L., Wei, X., Qin, Y., & Bi, Z. (2026). Pantothenic Acid Protects Neurons After Ischemic Stroke by Targeting ID3 to Restore Action Potential Amplitude. Journal of neuroscience research, 104(5), e70130. https://
BibTeX
@article{chen2026pantoth
author = {Chen, Hongqiao and Chen, Mingli and Meng, Lian and Wei, Xing and Qin, Yan and Bi, Zhumei},
title = {{Pantothenic Acid Protects Neurons After Ischemic Stroke by Targeting ID3 to Restore Action Potential Amplitude}},
journal = {Journal of neuroscience research},
year = {2026},
month = may,
volume = {104},
number = {5},
pages = {e70130},
publisher = {Wiley},
issn = {0360-4012},
doi = {10.1002/
url = {https://
pmid = {42130286},
pmcid = {PMC13172942}
}
RIS
TY - JOUR
AU - Chen, Hongqiao
AU - Chen, Mingli
AU - Meng, Lian
AU - Wei, Xing
AU - Qin, Yan
AU - Bi, Zhumei
TI - Pantothenic Acid Protects Neurons After Ischemic Stroke by Targeting ID3 to Restore Action Potential Amplitude
T2 - Journal of neuroscience research
J2 - J Neurosci Res
PY - 2026
DA - 2026/
VL - 104
IS - 5
SP - e70130
SN - 0360-4012
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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