OSCR

Propranolol alleviates cerebral infarction through the β2-AR-mediated ERK/NLRP3 pathway.

Overview

Authors: Meng-Meng Zhu1, Tian-Xiao Li1, Xue-Ting Liu1, Xiu Chen1, Na Zhao1, Fan Geng1, Zhi-Jun Zhang1,2, Lei Zuo1,2, Qing-Guo Ren1,2
  1. Department of Neurology, School of Medicine, Southeast University, #87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China
  2. Department of Neuropsychiatry, Zhongda Hospital Affiliated to Southeast University, #87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China
Journal: iScience, volume 29, issue 5, article 115779
Dates: received 4 September 2025; accepted 15 April 2026; published online 17 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.115779 · PMID 42111174 · PMCID PMC13156568 · OpenAlex W7154687926
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: mouse (organism), stroke (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: biological sciences, cell biology, molecular biology
Topic: Inflammasome and immune disorders (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Citations: not cited yet (Europe PMC); 71 references in the paper
Research resources: GAPDH antibody RRID:AB_2107448, RRID:AB_2630356, Recombinant Anti-Iba1 antibody RRID:AB_2636859, RRID:AB_2650602, Anti-Occludin antibody RRID:AB_2737295, Recombinant Anti-ERK1 + ERK2 antibody RRID:AB_2802136, IL-1 beta antibody RRID:AB_2880351, Recombinant Anti-NLRP3 antibody RRID:AB_2889890, Recombinant Anti-CD31 antibody RRID:AB_2920881, RRID:AB_2934088, Goat Anti-Rabbit IgG H&L (HRP) RRID:AB_955447

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.

Data

No dataset and no data link were found in the paper.

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1016/j.isci.2026.115779.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 3 keywords, 2 funders, 71 references, 11 RRIDs.

Cite

This paper

Zhu, M.-M., Li, T.-X., Liu, X.-T., Chen, X., Zhao, N., Geng, F., Zhang, Z.-J., Zuo, L., & Ren, Q.-G. (2026). Propranolol alleviates cerebral infarction through the β2-AR-mediated ERK/NLRP3 pathway. iScience, 29(5), 115779. https://doi.org/10.1016/j.isci.2026.115779

BibTeX

@article{zhu2026propranolol,
author = {Zhu, Meng-Meng and Li, Tian-Xiao and Liu, Xue-Ting and Chen, Xiu and Zhao, Na and Geng, Fan and Zhang, Zhi-Jun and Zuo, Lei and Ren, Qing-Guo},
title = {{Propranolol alleviates cerebral infarction through the β2-AR-mediated ERK/NLRP3 pathway}},
journal = {iScience},
year = {2026},
month = apr,
volume = {29},
number = {5},
pages = {115779},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.115779},
url = {https://doi.org/10.1016/j.isci.2026.115779},
pmid = {42111174},
pmcid = {PMC13156568}
}

RIS

TY - JOUR
AU - Zhu, Meng-Meng
AU - Li, Tian-Xiao
AU - Liu, Xue-Ting
AU - Chen, Xiu
AU - Zhao, Na
AU - Geng, Fan
AU - Zhang, Zhi-Jun
AU - Zuo, Lei
AU - Ren, Qing-Guo
TI - Propranolol alleviates cerebral infarction through the β2-AR-mediated ERK/NLRP3 pathway
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/04/17
VL - 29
IS - 5
SP - 115779
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.115779
UR - https://doi.org/10.1016/j.isci.2026.115779
LA - en
ER -

CSL-JSON

{
"id": "10.1016/j.isci.2026.115779",
"type": "article-journal",
"title": "Propranolol alleviates cerebral infarction through the β2-AR-mediated ERK/NLRP3 pathway",
"container-title": "iScience",
"author": [
{
"family": "Zhu",
"given": "Meng-Meng"
},
{
"family": "Li",
"given": "Tian-Xiao"
},
{
"family": "Liu",
"given": "Xue-Ting"
},
{
"family": "Chen",
"given": "Xiu"
},
{
"family": "Zhao",
"given": "Na"
},
{
"family": "Geng",
"given": "Fan"
},
{
"family": "Zhang",
"given": "Zhi-Jun"
},
{
"family": "Zuo",
"given": "Lei"
},
{
"family": "Ren",
"given": "Qing-Guo"
}
],
"container-title-short": "iScience",
"volume": "29",
"issue": "5",
"page": "115779",
"DOI": "10.1016/j.isci.2026.115779",
"PMID": "42111174",
"PMCID": "PMC13156568",
"ISSN": "2589-0042",
"publisher": "Elsevier",
"URL": "https://doi.org/10.1016/j.isci.2026.115779",
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
17
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1016/j.redox.2026.104210
Vespakinin-M delineates an AMPK/mTOR-arginine-TCA cycle axis to act as an immunometabolic switch in post-stroke microglia.
Journal: Redox biology
In common: stroke, mouse, cellular / molecular, 2 references
[2] doi:10.1002/jev2.70295
RVG-Modified BMSCs-Derived Small Extracellular Vesicles Loaded With miR-21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/Akt/mTOR Pathway After Cerebral Ischaemia.
Journal: Journal of extracellular vesicles
In common: stroke, mouse, cellular / molecular, 2 references
[3] doi:10.1007/s10565-026-10177-0
Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke.
Journal: Cell biology and toxicology
In common: stroke, mouse, cellular / molecular, 2 references
[4] doi:10.1002/glia.70163
A Cross-Disease Microglial Transcriptional Program Characterizes Neurodegeneration and Highlights SPP1 as a Biomarker.
Journal: Glia
In common: mouse, cellular / molecular, 2 references
[5] doi:10.1016/j.crmeth.2026.101476 [code]
Unsupervised deep learning enables blur-free resolution enhancement in two-photon microscopy.
Journal: Cell reports methods
In common: mouse, cellular / molecular, 2 references
[6] doi:10.1038/s41467-026-71643-1 [code]
Pericytes are organ-specific regulators of tissue morphogenesis.
Journal: Nature communications
In common: mouse, cellular / molecular, 2 references
[7] doi:10.1016/j.isci.2026.116575 [code]
Mapping human microglial morphological diversity via handcrafted and deep learning-derived image features.
Journal: iScience
In common: cellular / molecular, 2 references
[8] doi:10.3389/fnins.2026.1805957
Treadmill training induces sex-dependent changes in hippocampal epigenetic patterns and plaque-associated microglial morphology in aged TgF344 rats.
Journal: Frontiers in neuroscience
In common: cellular / molecular, 2 references
[9] doi:10.1002/brb3.71700
Downregulation of Lgals3 Alleviates Inflammatory Response and Apoptosis in a Mouse Model of Cerebral Ischemia/Reperfusion Injury.
Journal: Brain and behavior
In common: stroke, mouse, cellular / molecular, 1 reference
[10] doi:10.1161/jaha.125.046208
Integration of Genome-Wide Association Studies With Single-Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes.
Journal: Journal of the American Heart Association
In common: stroke, mouse, cellular / molecular, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.