OSCR

Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair.

Overview

Authors: Tuoxin Cao1,2, Matin Hemati-Gourabi1,2, Yongliang Liu1,2, Anna E Mills1, Lauren Baur1, Ellie P Rice1, Theo Klippel1, Yiwen Yan1, Xiu Xu1, William K Fenske1, Jean X Jiang3, Meifan Chen1,4,5
ORCID iDs: Meifan Chen
  1. Spinal Cord and Brain Injury Research Center, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
  2. These authors contributed equally
  3. Department of Biochemistry and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
  4. Department of Neuroscience, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
  5. Lead contact
Institutions: University of Kentucky (United States); The University of Texas at San Antonio Health Science Center (United States)
Journal: Cell reports, volume 45, issue 6, article 117418
Dates: published online 30 May 2026; in print 23 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.celrep.2026.117418 · PMID 42217185 · PMCID PMC13366903 · OpenAlex W7162763639
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, fMRI & imaging
Keywords: Spinal cord injury, CNS repair, IFN-β, CNS injury, Interferon Response, Reactive Astrocytes, Csf1, Astrocyte-microglia Interaction, Cp: Neuroscience, Glia Crosstalk, Wound Repair Astrogliosis
MeSH: Astrocytes*, Central Nervous System*, Interferon-beta*, Macrophage Colony-Stimulating Factor*, Microglia*, Animals, Cell Communication, Mice, Mice, Inbred C57BL, Signal Transduction, Spinal Cord Injuries, Wound Healing (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: NINDS NIH HHS (R21 NS137256, R01 NS121193); Kentucky Spinal Cord and Head Injury Research Board; National Institutes of Health; National Institute of Neurological Disorders and Stroke (NS121193, NS137256); Craig H Neilsen Foundation (1170750, 1176076)
Citations: not cited yet (Europe PMC); 73 references in the paper
Research resources: GFAP RRID:AB_10013382, IFNβ RRID:AB_11039065, IBA1 RRID:AB_11156585, Donkey anti-mouse Alexa Fluor 546 RRID:AB_11180613, NeuN RRID:AB_11205592, CD45 RRID:AB_2174426, SOX9 RRID:AB_2194160, IGF1 RRID:AB_2248752, GFAP RRID:AB_2532994, Donkey anti-rabbit Alexa Fluor 568 RRID:AB_2534017, Donkey anti-goat Alexa Fluor 488 RRID:AB_2534102, Donkey anti-goat Alexa Fluor 568 RRID:AB_2534104, Goat anti-guinea pig Alexa Fluor 546 RRID:AB_2534118, Goat anti-rat Alexa Fluor 568 RRID:AB_2534121, Donkey anti-rabbit Alexa Fluor 488 RRID:AB_2535792, Donkey anti-rabbit Alexa Fluor 647 RRID:AB_2536183, Donkey anti-rat Alexa Fluor 650 RRID:AB_2556609, BV421 Ly6G RRID:AB_2562567, APC-CD45 RRID:AB_2658220, PEconjugated CD11b RRID:AB_2726045, NeuN RRID:AB_2736206, CSF1 RRID:AB_2764828, PE-ACSA2 RRID:AB_2811488, Donkey anti-goat Alexa Fluor 647 RRID:AB_2910635, Ki67 RRID:AB_393778, Neurofilament 200 RRID:AB_477272, IBA1 RRID:AB_839504, R-Studio v2025.09.2 build 418 RRID:SCR_000432, R v4.5.1 RRID:SCR_001905, GraphPad Prism v10.4.1 RRID:SCR_002798, ImageJ v1.54f RRID:SCR_003070, FlowJo v10.10.0 RRID:SCR_008520, ggplot2 v4.0.3 RRID:SCR_014601, pheatmap v1.0.12 RRID:SCR_016418, RColorBrewer v1.1-3 RRID:SCR_016697, mixOmics v6.18.0 RRID:SCR_016889, BioRender RRID:SCR_018361, ShinyGO v0.85.1 RRID:SCR_019213

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

ncbi.nlm.nih.gov/geo/query

License: none: the authors keep all their rights
State: the link answers, verified on 27 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: the text, “Footnotes”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source: ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326801

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: n/a → Cell Press
  • Authors: added Meifan Chen (0000-0002-4190-4001); removed Meifan Chen

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 11 keywords, 12 MeSH terms, 5 funders, 72 references, 38 RRIDs.

Cite

This paper

Cao, T., Hemati-Gourabi, M., Liu, Y., Mills, A. E., Baur, L., Rice, E. P., Klippel, T., Yan, Y., Xu, X., Fenske, W. K., Jiang, J. X., & Chen, M. (2026). Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair. Cell reports, 45(6), 117418. https://doi.org/10.1016/j.celrep.2026.117418

BibTeX

@article{cao2026astrocyte,
author = {Cao, Tuoxin and Hemati-Gourabi, Matin and Liu, Yongliang and Mills, Anna E and Baur, Lauren and Rice, Ellie P and Klippel, Theo and Yan, Yiwen and Xu, Xiu and Fenske, William K and Jiang, Jean X and Chen, Meifan},
title = {{Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair}},
journal = {Cell reports},
year = {2026},
month = may,
volume = {45},
number = {6},
pages = {117418},
publisher = {Cell Press},
issn = {2211-1247},
doi = {10.1016/j.celrep.2026.117418},
url = {https://doi.org/10.1016/j.celrep.2026.117418},
pmid = {42217185},
pmcid = {PMC13366903}
}

RIS

TY - JOUR
AU - Cao, Tuoxin
AU - Hemati-Gourabi, Matin
AU - Liu, Yongliang
AU - Mills, Anna E
AU - Baur, Lauren
AU - Rice, Ellie P
AU - Klippel, Theo
AU - Yan, Yiwen
AU - Xu, Xiu
AU - Fenske, William K
AU - Jiang, Jean X
AU - Chen, Meifan
TI - Astrocyte-microglia crosstalk via CSF1 and IFN-β promotes central nervous system repair
T2 - Cell reports
J2 - Cell Rep
PY - 2026
DA - 2026/05/30
VL - 45
IS - 6
SP - 117418
SN - 2211-1247
PB - Cell Press
DO - 10.1016/j.celrep.2026.117418
UR - https://doi.org/10.1016/j.celrep.2026.117418
LA - en
ER -

CSL-JSON

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