Ten3-Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly.
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MATLAB · 118 lines · 4.7 KB · no license
Fig. 2 analysis.m at commit 1f862bd, no license · at the source
Overview
- Department of Biology, Howard Hughes Medical Institute, Stanford University, Stanford, CA, 94305, USA
- Neurosciences Interdepartmental PhD Program, Stanford University, Stanford, CA, 94305, USA
- Present address: Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA
Abstract
How do thousands of cell-surface proteins specify billions of neuronal connections in developing brains? We previously found that inverse expression of a ligand–receptor pair, teneurin-3 (Ten3) and latrophilin-2 (Lphn2) in CA1 and subiculum, instructs CA1→subiculum target selection through Ten3–Ten3 homophilic attraction and Ten3–Lphn2 heterophilic reciprocal repulsions. Here, we leveraged conditional knockouts to demonstrate that these mechanisms generalize to extended hippocampal networks, including entorhinal cortex and hypothalamus. Cooperation between attraction and repulsion differs depending on the order in which developing axons encounter the attractant and repellent subfields. Ten3 and Lphn2 can serve both as ligands for incoming axons and receptors for their own target selection, within the same neuron; Ten3 can be repulsive or attractive as ligand or receptor. Thus, multifunctionality and repeated use, together with recurrent circuit motifs prevalent in the brain, enable one ligand–receptor pair to instruct target selection of many more neurons.
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dpederick/Reciprocal-repulsions-instruct-the-precise-assembly-of-parallel-hippocampal-networks
1f862bddf0d5b3aa9d6a5de7f56a77145413930a, 31 March 2021Availability: 1 check, the latest on 28 September 2026: the link answers
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Data and code availability
Data reported in this paper are available from lead contact upon request.
Data was normalized using custom MATLAB code (resample.m), previously published in Pederick et al. 20219 and can be found here: https://
Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.
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Version 2, 28 September 2026
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 10 keywords, 8 MeSH terms, 10 funders, 57 references, 11 RRIDs.
Cite
This paper
Gingrich, E. C., Pederick, D. T., Zhang, Y., & Luo, L. (2026). Ten3-Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly. Current biology : CB, 36(10), 2622-2636.e5. https://
BibTeX
@article{gingrich2026ten
author = {Gingrich, Ellen C. and Pederick, Daniel T. and Zhang, Yanbo and Luo, Liqun},
title = {{Ten3-Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly}},
journal = {Current biology : CB},
year = {2026},
month = may,
volume = {36},
number = {10},
pages = {2622--2636.e5},
publisher = {Elsevier BV},
issn = {0960-9822},
doi = {10.1016/
url = {https://
pmid = {42105755},
pmcid = {PMC13250448}
}
RIS
TY - JOUR
AU - Gingrich, Ellen C.
AU - Pederick, Daniel T.
AU - Zhang, Yanbo
AU - Luo, Liqun
TI - Ten3-Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly
T2 - Current biology : CB
J2 - Curr Biol
PY - 2026
DA - 2026/
VL - 36
IS - 10
SP - 2622
EP - 2636.e5
SN - 0960-9822
PB - Elsevier BV
DO - 10.1016/
UR - https://
LA - en
ER -
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