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Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19.

Overview

Authors: Simon Couly1, Yuko Yasui1, Ioannis Grammatikakis2, Yuriko Kimura1, Joshua J. Hinkle3, Juan L. Gomez4, Hsiang-En Wu1, Ashish Lal2, Michael Michaelides4, Brandon K. Harvey3, Tsung-Ping Su1
ORCID iDs: Simon Couly, Juan L. Gomez
  1. Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Suite 3512, 333 Cassell Drive, Baltimore, MD 21224, USA
  2. Regulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD 20892, USA
  3. Cellular Stress and Inflammation Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA
  4. Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Biomedical Research Center, 251 Bayview Boulevard, Baltimore, MD 21224, USA
Institutions: National Institutes of Health (United States); National Institute on Drug Abuse (United States); National Cancer Institute (United States); Center for Cancer Research (United States); United States Department of Health and Human Services (United States)
Journal: iScience, volume 29, issue 6, article 116092
Dates: received 28 April 2025; accepted 7 May 2026; published online 26 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.isci.2026.116092 · PMID 42256306 · PMCID PMC13233774 · OpenAlex W4412791844
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.07.28.667250
Status: code on request
Categories: PET / SPECT (modality), mouse (organism), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials
Keywords: molecular biology, neuroscience
Topic: Pharmacological Receptor Mechanisms and Effects (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Intramural Research Program; NIH
Citations: not cited yet (Europe PMC); 84 references in the paper
Research resources: Mouse monoclonal anti-MTCO1 RRID:AB_10374492, Mouse monoclonal anti-Enolase RRID:AB_10609119, Rabbit monoclonal anti-GAPDH RRID:AB_10622025, RRID:AB_10956166, Rabbit polyclonal anti-SDHA RRID:AB_11182164, Rabbit polyclonal anti-Hexokinase RRID:AB_11182717, Rabbit polyclonal anti-ATP5A1 RRID:AB_2061761, Rabbit polyclonal anti-LDHA RRID:AB_2137173, Rabbit polyclonal anti-GRIM19 RRID:AB_2150609, Rabbit monoclonal anti-PDH RRID:AB_2162926, Rabbit monoclonal anti-PKM RRID:AB_2163695, Rabbit polyclonal anti-UQCRC2 RRID:AB_2241442, B5 anti-S1R receptor antibody RRID:AB_2285870, Rabbit polyclonal anti-Sigma-1 receptor RRID:AB_2301712, Rabbit polyclonal anti-MAP2 RRID:AB_2722660, RRID:AB_621842, Peredox NADH/NAD+ cytosolic sensor RRID:Addgene_163060

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

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Read it in the paper: doi.org/10.1016/j.isci.2026.116092.

Versions

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Version 2, 28 September 2026

  • Authors: added Juan L. Gomez (0000-0003-3170-9904); removed Juan L. Gomez

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 2 keywords, 2 funders, 84 references, 17 RRIDs.

Cite

This paper

Couly, S., Yasui, Y., Grammatikakis, I., Kimura, Y., Hinkle, J. J., Gomez, J. L., Wu, H.-E., Lal, A., Michaelides, M., Harvey, B. K., & Su, T.-P. (2026). Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19. iScience, 29(6), 116092. https://doi.org/10.1016/j.isci.2026.116092

BibTeX

@article{couly2026sigma,
author = {Couly, Simon and Yasui, Yuko and Grammatikakis, Ioannis and Kimura, Yuriko and Hinkle, Joshua J. and Gomez, Juan L. and Wu, Hsiang-En and Lal, Ashish and Michaelides, Michael and Harvey, Brandon K. and Su, Tsung-Ping},
title = {{Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19}},
journal = {iScience},
year = {2026},
month = may,
volume = {29},
number = {6},
pages = {116092},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.116092},
url = {https://doi.org/10.1016/j.isci.2026.116092},
pmid = {42256306},
pmcid = {PMC13233774}
}

RIS

TY - JOUR
AU - Couly, Simon
AU - Yasui, Yuko
AU - Grammatikakis, Ioannis
AU - Kimura, Yuriko
AU - Hinkle, Joshua J.
AU - Gomez, Juan L.
AU - Wu, Hsiang-En
AU - Lal, Ashish
AU - Michaelides, Michael
AU - Harvey, Brandon K.
AU - Su, Tsung-Ping
TI - Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/05/26
VL - 29
IS - 6
SP - 116092
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.116092
UR - https://doi.org/10.1016/j.isci.2026.116092
LA - en
ER -

CSL-JSON

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