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Sigma-1 Expression in Chronic Mouse Models of Temporal Lobe Epilepsy.

Overview

Authors: Victoria Magna Stocker1, Christian Lad1,2, Aleksandr Markov1,2, Heidrun Potschka1, Eva-Lotta von Rüden1
ORCID iDs: Victoria Magna Stocker, Heidrun Potschka, Eva-Lotta von Rüden
  1. Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-Universität München (LMU),Königinstr. 16, 80539 Munich, Germany
  2. Graduate School of Systemic Neurosciences, Munich Center for Neurosciences - Brain & Mind (MCN), Ludwig-Maximilians-Universität (LMU) München,Munich, Germany
Institutions: Ludwig-Maximilians-Universität München (Germany); Munich Center for Neurosciences – Brain and Mind (Germany)
Journal: Molecular neurobiology, volume 63, issue 1, article 855
Dates: received 18 February 2026; accepted 14 August 2026; published online 25 August 2026; in print 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1007/s12035-026-06155-6 · PMID 42642676 · PMCID PMC13506606 · OpenAlex W7204199648
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: histology / microscopy (modality), mouse (organism), epilepsy (population), cellular / molecular (subfield)
Methods: Statistics, Connectivity
Keywords: Antiseizure medication, Temporal lobe epilepsy, Intrahippocampal kainate model, Amygdala kindling model, Immunohistochemistry, Target validation
MeSH: Epilepsy, Temporal Lobe*, Receptors, sigma*, Amygdala, Animals, Astrocytes, Chronic Disease, Disease Models, Animal, Hippocampus, Kainic Acid, Kindling, Neurologic, Male, Mice, Mice, Inbred C57BL, Neurons, Sigma-1 Receptor (* major topic)
Topic: Pharmacological Receptor Mechanisms and Effects (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Ludwig-Maximilians-Universität München (1024)
Citations: not cited yet (Europe PMC); 101 references in the paper

Abstract

Sigma-1 is an atypical receptor protein that modulates neuronal excitability and cellular stress responses, making it a promising target for therapeutic epilepsy management. However, its expression profile following epileptogenic insults, during epileptogenesis, and following chronic epilepsy manifestation remains unclear. We investigated brain Sigma-1 expression immunohistochemically and via quantitative PCR in two chronic mouse models of temporal lobe epilepsy: the amygdala kindling and intrahippocampal kainate model. Thereby, different disease phases were considered from the early phase following an epileptogenic insult, epileptogenesis, to the chronic epileptic state with recurrent seizures. Sigma-1 expression was largely stable across the examined brain areas. Transient increases in expression intensity were observed 2 days after status epilepticus in the kainate model in the CA3 region of the hippocampus and the entorhinal cortex, whereas no persistent protein-level reductions were detected in the chronic phase. Descriptive coexpression analyses indicated Sigma-1 expression in excitatory and inhibitory neurons, astrocytes, and microglia. These findings indicate that Sigma-1 expression is preserved during epileptogenesis and chronic epilepsy, supporting the continued consideration of Sigma-1 as a potential therapeutic target in epilepsy management. The early alterations observed following an epileptogenic insult further support the rationale for investigating Sigma-1-directed interventions during epileptogenesis, including preventive antiepileptogenic approaches.

Supplementary Information: The online version contains supplementary material available at 10.1007/s12035-026-06155-6.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data

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Data Availability

The data are available through Figshare [10.6084/m9.figshare.33287073].

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 2, 28 September 2026

  • Publisher: n/a → Springer Science+Business Media

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 6 keywords, 15 MeSH terms, 1 funder, 100 references.

Cite

This paper

Stocker, V. M., Lad, C., Markov, A., Potschka, H., & von Rüden, E.-L. (2026). Sigma-1 Expression in Chronic Mouse Models of Temporal Lobe Epilepsy. Molecular neurobiology, 63(1), 855. https://doi.org/10.1007/s12035-026-06155-6

BibTeX

@article{stocker2026sigma,
author = {Stocker, Victoria Magna and Lad, Christian and Markov, Aleksandr and Potschka, Heidrun and von Rüden, Eva-Lotta},
title = {{Sigma-1 Expression in Chronic Mouse Models of Temporal Lobe Epilepsy}},
journal = {Molecular neurobiology},
year = {2026},
month = aug,
volume = {63},
number = {1},
pages = {855},
publisher = {Springer Science+Business Media},
issn = {0893-7648},
doi = {10.1007/s12035-026-06155-6},
url = {https://doi.org/10.1007/s12035-026-06155-6},
pmid = {42642676},
pmcid = {PMC13506606}
}

RIS

TY - JOUR
AU - Stocker, Victoria Magna
AU - Lad, Christian
AU - Markov, Aleksandr
AU - Potschka, Heidrun
AU - von Rüden, Eva-Lotta
TI - Sigma-1 Expression in Chronic Mouse Models of Temporal Lobe Epilepsy
T2 - Molecular neurobiology
J2 - Mol Neurobiol
PY - 2026
DA - 2026/08/25
VL - 63
IS - 1
SP - 855
SN - 0893-7648
PB - Springer Science+Business Media
DO - 10.1007/s12035-026-06155-6
UR - https://doi.org/10.1007/s12035-026-06155-6
LA - en
ER -

CSL-JSON

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