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1,25D3 reprograms mitochondrial quality control via sirtuin and sensitizes glioblastoma to chemotherapy.

Overview

Authors: Karrie M. Kiang1, Yixiong Shen1,2, Yogesh K.H. Wong1, Bo Chen1, Junbo Liao1, Anza Mnahal1, Wanjun Tang1, Zhiyuan Zhu3, Shuhan Cao1, Carmen S.C. Lo1, Sang Jin Lee4, Hongbo Guo2, Liyang Zhang5, Gilberto Ka-Kit Leung1,6,7
ORCID iDs: Karrie M. Kiang, Gilberto Ka-Kit Leung
  1. Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR
  2. Department of Neurosurgery Center, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou, China
  3. Department of Functional Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China
  4. Biofunctional Materials, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR
  5. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan, China
  6. Queen Mary Hospital, Hospital Authority, Hong Kong SAR
  7. Clinical Neuroscience Consortium, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR
Institutions: University of Hong Kong (Hong Kong SAR China); Zhujiang Hospital (China); Southern Medical University (China); Central South University (China); Xiangya Hospital Central South University (China); Hospital Authority (Hong Kong SAR China); Queen Mary Hospital (China)
Journal: Molecular therapy : the journal of the American Society of Gene Therapy, volume 34, issue 7, pages 4226-4242
Dates: received 29 October 2025; accepted 2 March 2026; published online 6 March 2026; in print 1 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.ymthe.2026.03.006 · PMID 41792999 · PMCID PMC13330008 · OpenAlex W7134117333
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Evoked potentials
Keywords: glioblastoma, cancer metabolism, mitophagy, sirtuin, mitochondrial quality control, vitamin D, chemoresistance, metabolic vulnerability
MeSH: Glioblastoma*, Mitochondria*, Mitochondrial Proteins*, Sirtuins*, Animals, Cell Line, Tumor, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Humans, Metabolic Reprogramming, Mice, Mitophagy, Receptors, Calcitriol, Signal Transduction, Temozolomide (* major topic)
Topic: Sirtuins and Resveratrol in Medicine (Geriatrics and Gerontology, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82403157, 82373347); Key Area Research and Development Program of Guangdong Province, China (2023B1111020008); Science and Technology Program of Guangzhou, China (2025A04J3868)
Citations: cited by 2 papers (Europe PMC); 46 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1016/j.ymthe.2026.03.006.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 8 keywords, 15 MeSH terms, 3 funders, 46 references.

Cite

This paper

Kiang, K. M., Shen, Y., Wong, Y. K., Chen, B., Liao, J., Mnahal, A., Tang, W., Zhu, Z., Cao, S., Lo, C. S., Lee, S. J., Guo, H., Zhang, L., & Leung, G. K.-K. (2026). 1,25D3 reprograms mitochondrial quality control via sirtuin and sensitizes glioblastoma to chemotherapy. Molecular therapy : the journal of the American Society of Gene Therapy, 34(7), 4226-4242. https://doi.org/10.1016/j.ymthe.2026.03.006

BibTeX

@article{kiang20261,
author = {Kiang, Karrie M. and Shen, Yixiong and Wong, Yogesh K.H. and Chen, Bo and Liao, Junbo and Mnahal, Anza and Tang, Wanjun and Zhu, Zhiyuan and Cao, Shuhan and Lo, Carmen S.C. and Lee, Sang Jin and Guo, Hongbo and Zhang, Liyang and Leung, Gilberto Ka-Kit},
title = {{1,25D3 reprograms mitochondrial quality control via sirtuin and sensitizes glioblastoma to chemotherapy}},
journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
year = {2026},
month = mar,
volume = {34},
number = {7},
pages = {4226--4242},
publisher = {American Society of Gene \& Cell Therapy},
issn = {1525-0016},
doi = {10.1016/j.ymthe.2026.03.006},
url = {https://doi.org/10.1016/j.ymthe.2026.03.006},
pmid = {41792999},
pmcid = {PMC13330008}
}

RIS

TY - JOUR
AU - Kiang, Karrie M.
AU - Shen, Yixiong
AU - Wong, Yogesh K.H.
AU - Chen, Bo
AU - Liao, Junbo
AU - Mnahal, Anza
AU - Tang, Wanjun
AU - Zhu, Zhiyuan
AU - Cao, Shuhan
AU - Lo, Carmen S.C.
AU - Lee, Sang Jin
AU - Guo, Hongbo
AU - Zhang, Liyang
AU - Leung, Gilberto Ka-Kit
TI - 1,25D3 reprograms mitochondrial quality control via sirtuin and sensitizes glioblastoma to chemotherapy
T2 - Molecular therapy : the journal of the American Society of Gene Therapy
J2 - Mol Ther
PY - 2026
DA - 2026/03/06
VL - 34
IS - 7
SP - 4226
EP - 4242
SN - 1525-0016
PB - American Society of Gene & Cell Therapy
DO - 10.1016/j.ymthe.2026.03.006
UR - https://doi.org/10.1016/j.ymthe.2026.03.006
LA - en
ER -

CSL-JSON

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