OSCR

LRP4 is an entry receptor for multiple encephalitic alphaviruses.

Overview

Authors: Sicheng Tian1, Bingting Ma2, Hongyuan Guo1, Zhenlu Chong3, Theron C. Gilliland Jr.4, Sean Hui3, Guojie Wang1, Yuyi Zhang1, Jiayue Zhou1, Alan Sariol3, Xinran Sun1, Yingxin Hu5, Zhuohao He5, Daved H. Fremont3, William B. Klimstra4, Michael S. Diamond3, Ye Xiang2, Rong Zhang1
ORCID iDs: Zhenlu Chong, Sean Hui, Yuyi Zhang, Jiayue Zhou, Alan Sariol, Zhuohao He, Daved H. Fremont, William B. Klimstra, Michael S. Diamond, Ye Xiang, Rong Zhang
  1. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Fudan University,Shanghai, China
  2. Beijing Frontier Research Center for Biological Structure, Center for Infection Biology, School of Basic Medical Sciences, Tsinghua University,Beijing, China
  3. Departments of Medicine, Pathology & Immunology, and Molecular Microbiology, Washington University School of Medicine,St. Louis, MO USA
  4. The Center for Vaccine Research and Department of Immunology, The University of Pittsburgh,Pittsburgh, PA USA
  5. Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of the Chinese Academy of Sciences,Shanghai, China
Institutions: Fudan University (China); Tsinghua University (China); Washington University in St. Louis (United States); University of Pittsburgh (United States); Chinese Academy of Sciences (China)
Journal: Nature communications, volume 17, issue 1, article 7360
Dates: received 5 September 2025; accepted 19 May 2026; published online 9 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-73852-0 · PMID 42265108 · PMCID PMC13402676 · OpenAlex W7164042687
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Connectivity, Evoked potentials
Keywords: Alphaviruses, Virus-host interactions
MeSH: Alphavirus*, LDL-Receptor Related Proteins*, Receptors, Virus*, Virus Internalization*, Animals, Brain, Encephalitis Virus, Eastern Equine, HEK293 Cells, Humans, Male, Mice, Neurons, Receptors, LDL, Semliki forest virus, Sindbis Virus (* major topic)
Topic: Autoimmune Neurological Disorders and Treatments (Neurology, Medicine), according to OpenAlex
Funding: Shenzhen Medical Research Fund (SMRF No. B2302029 to R.Z.), Shanghai Municipal Science and Technology Major Project (ZD2021CY001 to R.Z.), Program of Shanghai Academic Research Leader (22XD1420600 to R.Z.), National Natural Science Foundation of China (81974305 to R.Z.), Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2023-PT310-02 to R.Z.); U.S. Government (Defense Threat Reduction Agency) under contracts W15QKN-16-9-1002 and MCDC2103-01 (to W.B.K.); National Institutes of Health (R01AI143673 and R01AI164653 to M.S.D.)
Citations: not cited yet (Europe PMC); 70 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-73852-0.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 18 authors, 2 keywords, 15 MeSH terms, 3 funders, 69 references.

Cite

This paper

Tian, S., Ma, B., Guo, H., Chong, Z., Gilliland, T. C., Hui, S., Wang, G., Zhang, Y., Zhou, J., Sariol, A., Sun, X., Hu, Y., He, Z., Fremont, D. H., Klimstra, W. B., Diamond, M. S., Xiang, Y., & Zhang, R. (2026). LRP4 is an entry receptor for multiple encephalitic alphaviruses. Nature communications, 17(1), 7360. https://doi.org/10.1038/s41467-026-73852-0

BibTeX

@article{tian2026lrp4,
author = {Tian, Sicheng and Ma, Bingting and Guo, Hongyuan and Chong, Zhenlu and Gilliland, Theron C. and Hui, Sean and Wang, Guojie and Zhang, Yuyi and Zhou, Jiayue and Sariol, Alan and Sun, Xinran and Hu, Yingxin and He, Zhuohao and Fremont, Daved H. and Klimstra, William B. and Diamond, Michael S. and Xiang, Ye and Zhang, Rong},
title = {{LRP4 is an entry receptor for multiple encephalitic alphaviruses}},
journal = {Nature communications},
year = {2026},
month = jun,
volume = {17},
number = {1},
pages = {7360},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-73852-0},
url = {https://doi.org/10.1038/s41467-026-73852-0},
pmid = {42265108},
pmcid = {PMC13402676}
}

RIS

TY - JOUR
AU - Tian, Sicheng
AU - Ma, Bingting
AU - Guo, Hongyuan
AU - Chong, Zhenlu
AU - Gilliland, Theron C.
AU - Hui, Sean
AU - Wang, Guojie
AU - Zhang, Yuyi
AU - Zhou, Jiayue
AU - Sariol, Alan
AU - Sun, Xinran
AU - Hu, Yingxin
AU - He, Zhuohao
AU - Fremont, Daved H.
AU - Klimstra, William B.
AU - Diamond, Michael S.
AU - Xiang, Ye
AU - Zhang, Rong
TI - LRP4 is an entry receptor for multiple encephalitic alphaviruses
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/06/09
VL - 17
IS - 1
SP - 7360
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-73852-0
UR - https://doi.org/10.1038/s41467-026-73852-0
LA - en
ER -

CSL-JSON

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