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Active conformations of neuronal Na<sup>+</sup>, K<sup>+</sup>-ATPase isoforms and a disease-causing mutant.

Overview

Authors: Mads Eskesen Christensen1,2, Michael Habeck1,2, Adriana Katz3, Marlene Uglebjerg Fruergaard1,2, Yoav Peleg4, Uri Pick3, Steven J. D. Karlish3, Poul Nissen1,2
ORCID iDs: Marlene Uglebjerg Fruergaard, Yoav Peleg, Uri Pick, Steven J. D. Karlish, Poul Nissen
  1. Danish Research Institute of Translational Neuroscience - DANDRITE, Nordic EMBL Partnership for Molecular Medicine, Aarhus University,Aarhus C, Denmark
  2. Dept. of Molecular Biology and Genetics, Aarhus University,Aarhus C, Denmark
  3. Dept. of Biomolecular Sciences, Weizmann Institute of Science,Rehovot, Israel
  4. Structural Proteomics Unit, Weizmann Institute of Science,Rehovot, Israel
Institutions: Aarhus University (Denmark); Weizmann Institute of Science (Israel)
Journal: Nature communications, volume 17, issue 1, article 9278
Dates: received 3 September 2025; accepted 15 July 2026; published online 29 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-75997-4 · PMID 42669691 · PMCID PMC13526833 · OpenAlex W7171696665
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: histology / microscopy (modality), human (organism), other condition (population), cellular / molecular (subfield)
Methods: fMRI & imaging
Keywords: Cryoelectron microscopy, Ion transport, Mechanisms of disease, Molecular neuroscience, Neurodevelopmental disorders
MeSH: Neurons*, Sodium-Potassium-Exchanging ATPase*, Animals, Binding Sites, Cryoelectron Microscopy, Hemiplegia, Humans, Isoenzymes, Models, Molecular, Mutation, Protein Conformation, Sodium (* major topic)
Topic: Ion Transport and Channel Regulation (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Lundbeck Foundation (R310-2018-3713); Novo Nordisk Fonden (NNF20OC0060483, CryoNET); Carlsbergfondet (Carlsberg Foundation) (CF22-1535, CF23-1394); EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) (793086)
Citations: not cited yet (Europe PMC); 84 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-75997-4.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 5 keywords, 12 MeSH terms, 4 funders, 83 references.

Cite

This paper

Christensen, M. E., Habeck, M., Katz, A., Fruergaard, M. U., Peleg, Y., Pick, U., Karlish, S. J. D., & Nissen, P. (2026). Active conformations of neuronal Na<sup>+</sup>, K<sup>+</sup>-ATPase isoforms and a disease-causing mutant. Nature communications, 17(1), 9278. https://doi.org/10.1038/s41467-026-75997-4

BibTeX

@article{christensen2026active,
author = {Christensen, Mads Eskesen and Habeck, Michael and Katz, Adriana and Fruergaard, Marlene Uglebjerg and Peleg, Yoav and Pick, Uri and Karlish, Steven J. D. and Nissen, Poul},
title = {{Active conformations of neuronal Na\<sup\>+\</sup\>, K\<sup\>+\</sup\>-ATPase isoforms and a disease-causing mutant}},
journal = {Nature communications},
year = {2026},
month = jul,
volume = {17},
number = {1},
pages = {9278},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-75997-4},
url = {https://doi.org/10.1038/s41467-026-75997-4},
pmid = {42669691},
pmcid = {PMC13526833}
}

RIS

TY - JOUR
AU - Christensen, Mads Eskesen
AU - Habeck, Michael
AU - Katz, Adriana
AU - Fruergaard, Marlene Uglebjerg
AU - Peleg, Yoav
AU - Pick, Uri
AU - Karlish, Steven J. D.
AU - Nissen, Poul
TI - Active conformations of neuronal Na<sup>+</sup>, K<sup>+</sup>-ATPase isoforms and a disease-causing mutant
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/07/29
VL - 17
IS - 1
SP - 9278
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-75997-4
UR - https://doi.org/10.1038/s41467-026-75997-4
LA - en
ER -

CSL-JSON

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"container-title": "Nature communications",
"author": [
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"family": "Christensen",
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"ISSN": "2041-1723",
"publisher": "Nature Publishing Group",
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"language": "en",
"issued": {
"date-parts": [
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