Application of the Allen Human Brain Atlas in Alzheimer's disease and Parkinson's disease.
Overview
- Laboratory of Neurodegenerative Disorders, Department of Neurology, Rare Disease Center, National Clinical Research Center for Geriatric, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan China
- Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041 Sichuan China
Abstract
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common age-related neurodegenerative disorders. Allen Human Brain Atlas (AHBA) provides high-resolution transcriptomic data across 102 brain regions with multi-site sampling from healthy controls, promoting the use of brain-wide transcriptomic data for imaging transcriptomics and cross-modal model construction. Increasingly, researchers are utilizing brain-wide transcriptomic datasets to investigate the transcriptome correlates of the neuroimage phenotypes in AD and PD. Leveraging the AHBA, researchers have analyzed the transcriptomic correlations of regional susceptibility to Aβ deposition, tau deposition, α-synuclein propagation, and disease-related multiple-dominal neuroimage phenotypes. These studies revealed that transcriptomic pathways related to metabolism, immunity, neurotransmission, and synaptic function play critical roles in the neuroimage phenotype of AD and PD. By incorporating transcriptomic data modeling, subsequent analyses further confirmed that transcriptomic differences provide the molecular basis for the varying susceptibility observed across brain regions. The analytical approaches of imaging transcriptomics, multimodal data integration strategies, and model construction methods used in AD and PD provide a novel perspective for exploration and can be extended to other neurodegenerative diseases. Future research is expected to utilize brain-wide transcriptomic data to uncover the gene expression mechanisms driving neurodegenerative disease phenotypes.
Supplementary Information: The online version contains supplementary material available at 10.1186/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- figshare:33076006, at figshare; found in DataCite
- geo:GSE73721, at NCBI GEO; found in the text, “Cell types associated with structural changes…”
Data availability
No datasets were generated or analysed during the current study.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 5 keywords, 7 MeSH terms, 5 funders, 101 references.
Cite
This paper
Xiao, Y., Wang, S., Hou, Y., & Shang, H. (2026). Application of the Allen Human Brain Atlas in Alzheimer's disease and Parkinson's disease. Translational neurodegeneration, 15(1), 33. https://
BibTeX
@article{xiao2026applica
author = {Xiao, Yi and Wang, Shichan and Hou, Yanbing and Shang, Huifang},
title = {{Application of the Allen Human Brain Atlas in Alzheimer's disease and Parkinson's disease}},
journal = {Translational neurodegeneration},
year = {2026},
month = jul,
volume = {15},
number = {1},
pages = {33},
publisher = {BMC},
issn = {2047-9158},
doi = {10.1186/
url = {https://
pmid = {42493790},
pmcid = {PMC13393942}
}
RIS
TY - JOUR
AU - Xiao, Yi
AU - Wang, Shichan
AU - Hou, Yanbing
AU - Shang, Huifang
TI - Application of the Allen Human Brain Atlas in Alzheimer's disease and Parkinson's disease
T2 - Translational neurodegeneration
J2 - Transl Neurodegener
PY - 2026
DA - 2026/
VL - 15
IS - 1
SP - 33
SN - 2047-9158
PB - BMC
DO - 10.1186/
UR - https://
LA - en
ER -
CSL-JSON
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