OSCR

Hierarchical organization of tau topography across the Alzheimer's disease continuum integrates amyloid, connectome, and intrinsic molecular vulnerability.

Overview

Authors: Zhi-Ming Zeng1,2, Shu-Shu Han3, Qin Liu4,5, Cui-Die Zeng1,2, Xin Jia1,2, Jing Bi1,2, Ling-Chen Liu1,2, Teng-Ao Gao1,2, Lei Liang6, Fang-Xiao Cheng1,2
ORCID iDs: Zhi-Ming Zeng, Shu-Shu Han, Lei Liang, Fang-Xiao Cheng
  1. Institute of Medical Technology, Peking University Health Science Center,Beijing, China
  2. Beijing Key Laboratory of Intelligent Neuromodulation and Brain Disorder Treatment, Beijing, China
  3. Department of Nutrition, Fuwai Shenzhen Hospital, Chinese Academy of Medical Sciences,Shenzhen, China
  4. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center,Guangzhou, P. R. China
  5. Department of Nasopharyngeal Cancer, Sun Yat-sen University Cancer Center,Guangzhou, China
  6. Department of Ultrasound, Aerospace Center Hospital,Beijing, China
Institutions: Peking University (China); Chinese Academy of Medical Sciences & Peking Union Medical College (China); Sun Yat-sen University Cancer Center (China); Aerospace Center Hospital (China)
Journal: Communications biology, volume 9, issue 1, article 1163
Dates: received 19 January 2026; accepted 21 May 2026; published online 3 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s42003-026-10388-5 · PMID 42230978 · PMCID PMC13534679 · OpenAlex W7163226226
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: PET / SPECT (modality), human (organism), other condition (population), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Connectivity, Statistics, Machine learning, fMRI & imaging, Smoothing, state filtering, decompositions
Keywords: Neurogenesis, Disorders of consciousness
MeSH: Alzheimer Disease*, Amyloid beta-Peptides*, Brain*, Connectome*, tau Proteins*, Female, Humans, Positron-Emission Tomography (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (62571010) Clinical Medicine Plus X-Young Scholars Project, Peking University, the Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China(62371010) Aerospace Medical & Healthcare Technology Group (2021YK01)
Citations: cited by 1 paper (Europe PMC); 75 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

Zenodo 20278594

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 2 files
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source:

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to the authors' code: Zenodo 20278594

Read it in the paper: doi.org/10.1038/s42003-026-10388-5.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1038/s42003-026-10388-5.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 2 keywords, 8 MeSH terms, 2 funders, 75 references.

Cite

This paper

Zeng, Z.-M., Han, S.-S., Liu, Q., Zeng, C.-D., Jia, X., Bi, J., Liu, L.-C., Gao, T.-A., Liang, L., & Cheng, F.-X. (2026). Hierarchical organization of tau topography across the Alzheimer's disease continuum integrates amyloid, connectome, and intrinsic molecular vulnerability. Communications biology, 9(1), 1163. https://doi.org/10.1038/s42003-026-10388-5

BibTeX

@article{zeng2026hierarchical,
author = {Zeng, Zhi-Ming and Han, Shu-Shu and Liu, Qin and Zeng, Cui-Die and Jia, Xin and Bi, Jing and Liu, Ling-Chen and Gao, Teng-Ao and Liang, Lei and Cheng, Fang-Xiao},
title = {{Hierarchical organization of tau topography across the Alzheimer's disease continuum integrates amyloid, connectome, and intrinsic molecular vulnerability}},
journal = {Communications biology},
year = {2026},
month = jun,
volume = {9},
number = {1},
pages = {1163},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/s42003-026-10388-5},
url = {https://doi.org/10.1038/s42003-026-10388-5},
pmid = {42230978},
pmcid = {PMC13534679}
}

RIS

TY - JOUR
AU - Zeng, Zhi-Ming
AU - Han, Shu-Shu
AU - Liu, Qin
AU - Zeng, Cui-Die
AU - Jia, Xin
AU - Bi, Jing
AU - Liu, Ling-Chen
AU - Gao, Teng-Ao
AU - Liang, Lei
AU - Cheng, Fang-Xiao
TI - Hierarchical organization of tau topography across the Alzheimer's disease continuum integrates amyloid, connectome, and intrinsic molecular vulnerability
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/06/03
VL - 9
IS - 1
SP - 1163
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/s42003-026-10388-5
UR - https://doi.org/10.1038/s42003-026-10388-5
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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