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Targeting the astrocyte-microglia EFEMP1-GALNT10 axis: a spatially programmable therapeutic strategy for hippocampal vulnerability in Alzheimer's disease.

Overview

Authors: Junting Liu1, Jing Liu1, Yujian Fan1, Congcong Liu1, Jingrong Cao1, Haixia Ma1, Yuli Hou1, Shuo Gao1, Peichang Wang1
ORCID iDs: Peichang Wang
  1. Department of Clinical Laboratory, Xuanwu Hospital, National Clinical Research Center for Geriatric Diseases, Capital Medical University, Beijing, China
Journal: Journal of translational medicine, volume 24, issue 1, article 699
Dates: received 25 October 2025; accepted 31 March 2026; published online 11 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12967-026-08098-x · PMID 41965693 · PMCID PMC13214142 · OpenAlex W7153510965
Open access: gold, a free copy (OpenAlex)
Status: dead link
Categories: genetics / omics (modality), human (organism), mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, fMRI & imaging, Spectral & time-frequency
Keywords: Alzheimer’s disease, Causal inference, Multi-omics integration, Single-cell genomics, Astrocyte-microglia crosstalk, EFEMP1-GALNT10 axis, Hippocampal vulnerability
MeSH: Alzheimer Disease*, Astrocytes*, Extracellular Matrix Proteins*, Hippocampus*, Microglia*, N-Acetylgalactosaminyltransferases*, Animals, Humans, Mice, Mice, Transgenic, Quantitative Trait Loci (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: The State Key Program of the National Natural Science Foundation of China grants (82030064); Natural Science Foundation of Beijing Municipality (L246009)
Citations: not cited yet (Europe PMC); 88 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

DrLiu-jt/snRNA-SMR

License: none: the authors keep all their rights
State: the link is dead, verified on 29 September 2026
Evidence: found in the paper
Software Heritage: not archived
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 29 September 2026: the link is dead
  • 29 September 2026: the link is dead

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to the authors' code: DrLiu-jt/snRNA-SMR
  • it says that the code is available on request

Read it in the paper: doi.org/10.1186/s12967-026-08098-x.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: NCBI GEO GSE188545
  • it points to the authors' code: DrLiu-jt/snRNA-SMR
  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1186/s12967-026-08098-x.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 7 keywords, 11 MeSH terms, 2 funders, 76 references.

Cite

This paper

Liu, J., Liu, J., Fan, Y., Liu, C., Cao, J., Ma, H., Hou, Y., Gao, S., & Wang, P. (2026). Targeting the astrocyte-microglia EFEMP1-GALNT10 axis: a spatially programmable therapeutic strategy for hippocampal vulnerability in Alzheimer's disease. Journal of translational medicine, 24(1), 699. https://doi.org/10.1186/s12967-026-08098-x

BibTeX

@article{liu2026targeting,
author = {Liu, Junting and Liu, Jing and Fan, Yujian and Liu, Congcong and Cao, Jingrong and Ma, Haixia and Hou, Yuli and Gao, Shuo and Wang, Peichang},
title = {{Targeting the astrocyte-microglia EFEMP1-GALNT10 axis: a spatially programmable therapeutic strategy for hippocampal vulnerability in Alzheimer's disease}},
journal = {Journal of translational medicine},
year = {2026},
month = apr,
volume = {24},
number = {1},
pages = {699},
publisher = {BMC},
issn = {1479-5876},
doi = {10.1186/s12967-026-08098-x},
url = {https://doi.org/10.1186/s12967-026-08098-x},
pmid = {41965693},
pmcid = {PMC13214142}
}

RIS

TY - JOUR
AU - Liu, Junting
AU - Liu, Jing
AU - Fan, Yujian
AU - Liu, Congcong
AU - Cao, Jingrong
AU - Ma, Haixia
AU - Hou, Yuli
AU - Gao, Shuo
AU - Wang, Peichang
TI - Targeting the astrocyte-microglia EFEMP1-GALNT10 axis: a spatially programmable therapeutic strategy for hippocampal vulnerability in Alzheimer's disease
T2 - Journal of translational medicine
J2 - J Transl Med
PY - 2026
DA - 2026/04/11
VL - 24
IS - 1
SP - 699
SN - 1479-5876
PB - BMC
DO - 10.1186/s12967-026-08098-x
UR - https://doi.org/10.1186/s12967-026-08098-x
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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