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Single-cell atlas reveals the key role of pro-inflammatory IREB2⁺ microglia subsets in the microenvironment of Alzheimer's disease.

A correction to this paper has been published: the notice, 42366234, from Europe PMC.

Overview

Authors: Wenzheng Rong1,2,3, Jing Xu4, Bo Li1,3, Yapeng Li1,2,3, Yuming Xu1,2,3
  1. Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan People’s Republic of China
  2. Tianjian Laboratory of Advanced Biomedical Sciences, School of life sciences, Zhengzhou University, Zhengzhou, Henan China
  3. NHC Key Laboratory of Prevention and Treatment of Cerebrovascular Diseases, Henan Key Laboratory of Cerebrovascular Diseases, Zhengzhou, Japan
  4. Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Institutions: Zhengzhou University (China); First Affiliated Hospital of Zhengzhou University (China)
Journal: Clinical and experimental medicine, volume 26, issue 1, article 231
Dates: received 4 April 2026; accepted 9 May 2026; published online 20 May 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s10238-026-02188-2 · PMID 42159858 · PMCID PMC13233937 · OpenAlex W7161787638
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), other condition (population), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Connectivity, Statistics, Smoothing, state filtering, decompositions, Machine learning
Keywords: Alzheimer’s disease, IREB2, Neuro-inflammation, IL-6, TNF-a
MeSH: Alzheimer Disease*, Iron Regulatory Protein 2*, Microglia*, Brain, Cell Line, Tumor, Cytokines, Humans, Inflammation, Signal Transduction, Single-Cell Analysis (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: National Key Research and Development Program of China (2017YFA0105003); National Natural Science Foundation of China (U1904207)
Citations: not cited yet (Europe PMC); 25 references in the paper
Notices: A correction to this paper has been published (42366234, from Europe PMC)

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Data availability statement

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Read it in the paper: doi.org/10.1007/s10238-026-02188-2.

Versions

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Version 2, 28 September 2026

  • Publisher: n/a → Springer Science+Business Media

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 5 keywords, 10 MeSH terms, 2 funders, 25 references, 1 integrity notice.

Cite

This paper

Rong, W., Xu, J., Li, B., Li, Y., & Xu, Y. (2026). Single-cell atlas reveals the key role of pro-inflammatory IREB2⁺ microglia subsets in the microenvironment of Alzheimer's disease. Clinical and experimental medicine, 26(1), 231. https://doi.org/10.1007/s10238-026-02188-2

BibTeX

@article{rong2026single,
author = {Rong, Wenzheng and Xu, Jing and Li, Bo and Li, Yapeng and Xu, Yuming},
title = {{Single-cell atlas reveals the key role of pro-inflammatory IREB2⁺ microglia subsets in the microenvironment of Alzheimer's disease}},
journal = {Clinical and experimental medicine},
year = {2026},
month = may,
volume = {26},
number = {1},
pages = {231},
publisher = {Springer Science+Business Media},
issn = {1591-8890},
doi = {10.1007/s10238-026-02188-2},
url = {https://doi.org/10.1007/s10238-026-02188-2},
pmid = {42159858},
pmcid = {PMC13233937}
}

RIS

TY - JOUR
AU - Rong, Wenzheng
AU - Xu, Jing
AU - Li, Bo
AU - Li, Yapeng
AU - Xu, Yuming
TI - Single-cell atlas reveals the key role of pro-inflammatory IREB2⁺ microglia subsets in the microenvironment of Alzheimer's disease
T2 - Clinical and experimental medicine
J2 - Clin Exp Med
PY - 2026
DA - 2026/05/20
VL - 26
IS - 1
SP - 231
SN - 1591-8890
PB - Springer Science+Business Media
DO - 10.1007/s10238-026-02188-2
UR - https://doi.org/10.1007/s10238-026-02188-2
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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