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Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults.

Overview

Authors: Hyun Woong Roh1,2,3, Sang Won Seo4, Seong Hye Choi5, Eun-Joo Kim6, Soo Hyun Cho7, Byeong C Kim7, Jin Wook Choi8, Young-Sil An9, Na-Rae Kim10, Bumhee Park10,11, Sun Min Lee12, So Young Moon12, Dongha Lee13, Chang Hyung Hong1, Sang Joon Son1, Eun Young Kim2,3,14
14 affiliations
  1. Department of Psychiatry, Ajou University School of Medicine, Suwon 16499, Republic of Korea
  2. Department of Biomedical Sciences, Graduate School of Ajou University, Suwon 16499, Republic of Korea
  3. BK21 R&E Initiative for Advanced Precision Medicine, Graduate School of Ajou University, Suwon 16499, Republic of Korea
  4. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea
  5. Department of Neurology, Inha University College of Medicine, Incheon 22212, Republic of Korea
  6. Department of Neurology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan 50612, Republic of Korea
  7. Department of Neurology, Chonnam National University Medical School, Chonnam National University Hospital, Gwangju 61469, Republic of Korea
  8. Department of Radiology, Ajou University School of Medicine, Seoul 16499, Republic of Korea
  9. Department of Nuclear Medicine and Molecular Imaging, Ajou University School of Medicine, Suwon 16499, Republic of Korea
  10. Department of Biomedical Informatics, Ajou University School of Medicine, Suwon 16499, Republic of Korea
  11. Office of Biostatistics, Ajou Research Institute for Innovative Medicine, Ajou University Medical Center, Suwon 16499, Republic of Korea
  12. Department of Neurology, Ajou University School of Medicine, Suwon 16499, Republic of Korea
  13. Cognitive Science Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea
  14. Department of Brain Science, Ajou University School of Medicine, Suwon 16499, Republic of Korea
Dates: received 13 October 2025; accepted 22 January 2026; published online 2 March 2026; in print 10 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2527236123 · PMID 41770932 · PMCID PMC12974411 · OpenAlex W7133234701
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: structural MRI / diffusion (modality), human (organism), other condition (population), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Preprocessing, Machine learning
Keywords: Alzheimer’s disease, biomarkers, cellular circadian period, neurodegeneration, dermal fibroblast
MeSH: Aging*, Alzheimer Disease*, Brain*, Circadian Rhythm*, Aged, Aged, 80 and over, Biomarkers, Female, Fibroblasts, Glial Fibrillary Acidic Protein, Humans, Male, tau Proteins (* major topic)
Topic: Circadian rhythm and melatonin (Endocrine and Autonomic Systems, Neuroscience), according to OpenAlex
Funding: Korea Ministry of Science and ICT (RS-2023-00267453, NRF-2019R1A5A2026045, RS-2023-00208490, RS-2022-KH130303, RS-2022-KH125898, RS-2021-KH113821, RS-2024-00406876); MOHW | Korea National Institute of Health (2024-ER0505-01); Ajou University Medical Center (M2020C046000038, M2023C046000094, M2024C046000078); Korea Ministry of Health and Welfare (RS-2024-00339665, RS-2025-02215497); Gyenggi Province (GRRCAjou2023-B02)
Citations: cited by 1 paper (Europe PMC); 74 references in the paper
Notices: A comment on this paper has been published (41941651, from Europe PMC)

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1073/pnas.2527236123.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 5 keywords, 13 MeSH terms, 5 funders, 72 references, 1 integrity notice.

Cite

This paper

Roh, H. W., Seo, S. W., Choi, S. H., Kim, E.-J., Cho, S. H., Kim, B. C., Choi, J. W., An, Y.-S., Kim, N.-R., Park, B., Lee, S. M., Moon, S. Y., Lee, D., Hong, C. H., Son, S. J., & Kim, E. Y. (2026). Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults. Proceedings of the National Academy of Sciences of the United States of America, 123(10), e2527236123. https://doi.org/10.1073/pnas.2527236123

BibTeX

@article{roh2026cellular,
author = {Roh, Hyun Woong and Seo, Sang Won and Choi, Seong Hye and Kim, Eun-Joo and Cho, Soo Hyun and Kim, Byeong C and Choi, Jin Wook and An, Young-Sil and Kim, Na-Rae and Park, Bumhee and Lee, Sun Min and Moon, So Young and Lee, Dongha and Hong, Chang Hyung and Son, Sang Joon and Kim, Eun Young},
title = {{Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = mar,
volume = {123},
number = {10},
pages = {e2527236123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2527236123},
url = {https://doi.org/10.1073/pnas.2527236123},
pmid = {41770932},
pmcid = {PMC12974411}
}

RIS

TY - JOUR
AU - Roh, Hyun Woong
AU - Seo, Sang Won
AU - Choi, Seong Hye
AU - Kim, Eun-Joo
AU - Cho, Soo Hyun
AU - Kim, Byeong C
AU - Choi, Jin Wook
AU - An, Young-Sil
AU - Kim, Na-Rae
AU - Park, Bumhee
AU - Lee, Sun Min
AU - Moon, So Young
AU - Lee, Dongha
AU - Hong, Chang Hyung
AU - Son, Sang Joon
AU - Kim, Eun Young
TI - Cellular circadian period and its deviation associate with Alzheimer's pathology and brain aging in cognitively impaired older adults
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/03/02
VL - 123
IS - 10
SP - e2527236123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2527236123
UR - https://doi.org/10.1073/pnas.2527236123
LA - en
ER -

CSL-JSON

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"PMID": "41770932",
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"language": "en",
"issued": {
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