GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain.
Overview
- Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095
- Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095
- Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala 75185, Sweden
- Department of Neurology, Emory University, Atlanta, GE 30329
- Laboratory for Experimental Medicine, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46225
- Finsen Laboratory Copenhagen University Hospital–Rigshospitalet, Copenhagen N DK-2200, Denmark
- Biotechnology Research and Innovation Centre, University of Copenhagen, Copenhagen N DK-2200, Denmark
- Department of Medicine-Huddinge, Karolinska Institute Campus Flemingsberg, Huddinge SE-141 83, Sweden
- Department of Human Genetics, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095
Abstract
In peripheral tissues, lipoprotein lipase (LPL) is secreted by parenchymal cells (adipocytes, myocytes) into the interstitial spaces, where it is captured by GPIHBP1 (a glycosylphosphatidylinos
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
The paper's code and data availability statement is in the Data section.
Tracing map
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Data
Datasets cited
- geo:GSE253462, at NCBI GEO; found in the text, “Single-Cell and Single-Nuclei Transcriptomics.”
Data, Materials, and Software Availability
Study data are included in the article and/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 4 keywords, 7 MeSH terms, 5 funders, 85 references.
Cite
This paper
Liu, M., Hung, M., Kozlov, E., Hung, M., Colaço-Gaspar, M., Roy, S., Tu, Y., Magaki, S. D., Williams, C. K., Andaloussi Mäe, M., Johnson, E. C. B., Siegel, R. W., Konrad, R. J., Ploug, M., Betsholtz, C., Beigneux, A. P., He, L., Fong, L. G., & Young, S. G. (2026). GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain. Proceedings of the National Academy of Sciences of the United States of America, 123(23), e2610646123. https://
BibTeX
@article{liu2026gpihbp1,
author = {Liu, Minjun and Hung, Madison and Kozlov, Ellen and Hung, Megan and Colaço-Gaspar, Mariana and Roy, Shristi and Tu, Yiping and Magaki, Shino D and Williams, Christopher K and Andaloussi Mäe, Maarja and Johnson, Erik C B and Siegel, Robert W and Konrad, Robert J and Ploug, Michael and Betsholtz, Christer and Beigneux, Anne P and He, Liqun and Fong, Loren G and Young, Stephen G},
title = {{GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = jun,
volume = {123},
number = {23},
pages = {e2610646123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/
url = {https://
pmid = {42224591},
pmcid = {PMC13250511}
}
RIS
TY - JOUR
AU - Liu, Minjun
AU - Hung, Madison
AU - Kozlov, Ellen
AU - Hung, Megan
AU - Colaço-Gaspar, Mariana
AU - Roy, Shristi
AU - Tu, Yiping
AU - Magaki, Shino D
AU - Williams, Christopher K
AU - Andaloussi Mäe, Maarja
AU - Johnson, Erik C B
AU - Siegel, Robert W
AU - Konrad, Robert J
AU - Ploug, Michael
AU - Betsholtz, Christer
AU - Beigneux, Anne P
AU - He, Liqun
AU - Fong, Loren G
AU - Young, Stephen G
TI - GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/
VL - 123
IS - 23
SP - e2610646123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/
UR - https://
LA - en
ER -
CSL-JSON
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