Differential Gene Expression in Human Hippocampus With Aging.
Overview
- Group of Cellular Oncology, Biogipuzkoa (Biodonostia) Health Research Institute, San Sebastian, Spain
- Pathology Department, Donostia University Hospital, San Sebastian, Spain
- Neuroimmunology Group, Biogipuzkoa (Biodonostia) Health Research Institute, San Sebastian, Spain
- CIBER of Neurodegenerative Diseases (CIBERNED), Carlos III Institute, Madrid, Spain
- Department of Basic Psychological Processes and Their Development, School of Psychology, University of the Basque Country (UPV/EHU), San Sebastian, Spain
- BIOMICs Research Group, Microfluidics & BIOMICs Cluster, Department of Pharmacy and Food Sciences, Lascaray Research Center, University of the Basque Country (UPV/EHU), Vitoria, Spain
- CIBER of Frailty and Healthy Aging (CIBERFES), Carlos III Institute, Madrid, Spain
- IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
Abstract
Brain aging consists of a progressive loss of functional capacities, which is associated with a progressive cognitive decline and can lead to neurodegenerative diseases. Studies comparing the underlying molecular mechanisms of the human hippocampus between young and older adults remain scarce. In our study, we completed a transcriptomic analysis from hippocampal samples of different ages and performed 2 complementary analyses. A comparison between young and old groups revealed a set of genes differentially expressed in aged individuals linked to inflammation and immune system pathways, DNA repair, metabolism, or neural activity. Correlation analysis showed that the expression of an additional subset of 6 genes was associated with chronological aging. Among them, further analysis identified RAD23B as the most significant gene with a negative correlation of its mRNA and protein expression with age in the human hippocampus. Its expression was even lower in patients with Alzheimer's disease. RAD23B was mostly expressed in neurons and astrocytes, where studies in human primary cultures uncovered that it is required for cell survival and function. In summary, these results unravel dynamic gene expression changes that distinguish young from older adults and identify RAD23B as a putative biomarker and regulator of cell aging in the brain.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- geo:GSE201118, at NCBI GEO; found in “Data Availability Statement”
Other data links
- ncbi.nlm.nih.gov/
geo , NCBI; found in “Data Availability Statement”
Data Availability Statement
The data that support the findings of this study are openly available in NCBI's Gene Expression Omnibus at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 4 keywords, 14 MeSH terms, 2 funders, 45 references.
Cite
This paper
Saenz‐Antoñanzas, A., Moreno‐Valladares, M., Muñoz‐Culla, M., Cruces‐Salguero, S., Landa, J., Alberro, A., Vergara‐Arce, J., Arroyo‐Izaga, M., Otaegui, D., & Matheu, A. (2026). Differential Gene Expression in Human Hippocampus With Aging. Aging cell, 25(4), e70459. https://
BibTeX
@article{saenzantonanzas
author = {Saenz‐Antoñanzas, Ander and Moreno‐Valladares, Manuel and Muñoz‐Culla, Maider and Cruces‐Salguero, Sara and Landa, Jon and Alberro, Ainhoa and Vergara‐Arce, Jhonatan and Arroyo‐Izaga, Marta and Otaegui, David and Matheu, Ander},
title = {{Differential Gene Expression in Human Hippocampus With Aging}},
journal = {Aging cell},
year = {2026},
month = apr,
volume = {25},
number = {4},
pages = {e70459},
publisher = {Wiley},
issn = {1474-9718},
doi = {10.1111/
url = {https://
pmid = {41883201},
pmcid = {PMC13140639}
}
RIS
TY - JOUR
AU - Saenz‐Antoñanzas, Ander
AU - Moreno‐Valladares, Manuel
AU - Muñoz‐Culla, Maider
AU - Cruces‐Salguero, Sara
AU - Landa, Jon
AU - Alberro, Ainhoa
AU - Vergara‐Arce, Jhonatan
AU - Arroyo‐Izaga, Marta
AU - Otaegui, David
AU - Matheu, Ander
TI - Differential Gene Expression in Human Hippocampus With Aging
T2 - Aging cell
J2 - Aging Cell
PY - 2026
DA - 2026/
VL - 25
IS - 4
SP - e70459
SN - 1474-9718
PB - Wiley
DO - 10.1111/
UR - https://
LA - en
ER -
CSL-JSON
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