Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition.
A correction to this paper has been published: the notice, 42135991, from Europe PMC.
Overview
- Institute of Biochemistry and Cell Biology (IBBC), National Research Council of Italy (CNR), Rome, Italy
- Department of Ecological and Biological Sciences, University of Tuscia, Viterbo, Italy
- Department of Human Sciences, LUMSA University, Rome, Italy
- Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, Viterbo, Italy
- Onco‐Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant, Bambino Gesù Children's Hospital IRCCS, Rome, Italy
- Institute for Sustainable Plant Protection, National Research Council of Italy, Torino, Italy
- Institute of Biochemistry and Cell Biology, National Research Council of Italy (IBBC‐CNR/EMMA/INFRAFRONTIER/IMPC), Rome, Italy
Abstract
Hydroxytyrosol (HTyr), a phenolic compound present in olive oil, exhibits antioxidant, anti‐inflammatory, and neuroprotective properties, benefiting several age‐related diseases. Our previous research demonstrated that oral HTyr administration counteracts age‐associated neurogenesis decline in the dentate gyrus of the hippocampus by promoting the production of stem/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- bioproject:PRJNA1290279, at NCBI BioProject; found in “Data Availability Statement”
Data Availability Statement
The data of immunofluorescence and of behavioral tests generated and analyzed during this study are included in this article and its Supporting Information files. The raw data are available from the corresponding author on reasonable request. Moreover, all relevant NMR spectral data can be provided upon request. The data that support the findings of the microbiota analysis are openly available in NCBI Sequence Read Archive (SRA), at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Publisher: n/a → Wiley
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 6 keywords, 11 MeSH terms, 4 funders, 140 references, 25 RRIDs, 1 integrity notice.
Cite
This paper
D'Andrea, G., Bertini, L., Costanzi, M., Canini, F., Bernini, R., Fochetti, A., Clemente, M., Proietti, S., Ceccarelli, M., Caruso, C., Caruso, M., Scavizzi, F., Raspa, M., Tirone, F., & Micheli, L. (2026). Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition. Journal of neurochemistry, 170(5), e70448. https://
BibTeX
@article{dandrea2026hydr
author = {D'Andrea, Giorgio and Bertini, Laura and Costanzi, Marco and Canini, Fabiana and Bernini, Roberta and Fochetti, Andrea and Clemente, Mariangela and Proietti, Silvia and Ceccarelli, Manuela and Caruso, Carla and Caruso, Maurizia and Scavizzi, Ferdinando and Raspa, Marcello and Tirone, Felice and Micheli, Laura},
title = {{Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition}},
journal = {Journal of neurochemistry},
year = {2026},
month = may,
volume = {170},
number = {5},
pages = {e70448},
publisher = {Wiley},
issn = {0022-3042},
doi = {10.1111/
url = {https://
pmid = {42059580},
pmcid = {PMC13131041}
}
RIS
TY - JOUR
AU - D'Andrea, Giorgio
AU - Bertini, Laura
AU - Costanzi, Marco
AU - Canini, Fabiana
AU - Bernini, Roberta
AU - Fochetti, Andrea
AU - Clemente, Mariangela
AU - Proietti, Silvia
AU - Ceccarelli, Manuela
AU - Caruso, Carla
AU - Caruso, Maurizia
AU - Scavizzi, Ferdinando
AU - Raspa, Marcello
AU - Tirone, Felice
AU - Micheli, Laura
TI - Hydroxytyrosol Mitigates Anxiety-Like Behaviors After a Traumatic Experience in Aged Mice in Parallel With Increased Neurogenesis in the Ventral and Dorsal Dentate Gyrus, and Preservation of Gut Microbiota Composition
T2 - Journal of neurochemistry
J2 - J Neurochem
PY - 2026
DA - 2026/
VL - 170
IS - 5
SP - e70448
SN - 0022-3042
PB - Wiley
DO - 10.1111/
UR - https://
LA - en
ER -
CSL-JSON
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