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<i>Lactobacillus reuteri</i> DSM 17938 and Its Supernatant Ameliorate Parkinson's Disease in Association with Modulation of Gut Microbiota and Its Tryptophan Metabolism.

Overview

Authors: Bin Su1,2, Fanying Meng1,2, Yao Lu1,2, Yunlong Zhang1,2, Tingting Wang1,2, Yuxin Zhang1,2, Jiajia Liu1,2, Lianbing Lin1,2
ORCID iDs: Bin Su, Fanying Meng, Jiajia Liu
  1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China; (B.S.); (F.M.); (Y.L.); (Y.Z.); (T.W.); (Y.Z.); (J.L.)
  2. Engineering Research Center for Replacement Technology of Feed Antibiotics of Yunnan College, Kunming 650500, China
Institutions: Kunming University of Science and Technology (China)
Journal: Antioxidants (Basel, Switzerland), volume 15, issue 7, article 882
Dates: received 28 May 2026; accepted 14 July 2026; published online 16 July 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.3390/antiox15070882 · PMID 42510613 · PMCID PMC13406045 · OpenAlex W7168772981
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), Parkinson's (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Statistics, Machine learning, Smoothing, state filtering, decompositions
Keywords: Parkinson’s disease, gut microbiota, Lactobacillus reuteri DSM 17938, microbial tryptophan metabolites, probiotics
Topic: Gut microbiota and health (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Major Science and Technology Plan Special Project in Yunnan Province, China (CB22144SO29A)
Citations: not cited yet (Europe PMC); 54 references in the paper

Abstract

Parkinson’s disease (PD) is a neurodegenerative disorder associated with gut dysbiosis and tryptophan metabolism disturbance, but the mechanisms of probiotic action are unclear. We orally administered Lactobacillus reuteri DSM 17938 live bacteria (1.0 × 109 CFU/mL, 0.2 mL) or its fermentation supernatant lyophilized powder at three concentrations to MPTP-induced PD male C57BL/6J mice. Treatments increased locomotor distance and speed, elevated serum SOD and GSH, reduced MDA, TNF-α, IL-6, and IL-1β, promoted neuronal survival, and tended to increase TH expression in the substantia nigra. 16S rRNA sequencing showed that treatments altered gut microbiota composition. PD mice had increased Lactobacillus and Allobaculum but decreased Oscillospira and Helicobacter; treatments restored Oscillospira. Fecal untargeted metabolomics revealed disturbed tryptophan metabolism in PD, with elevated indoleacetic acid and reduced kynurenic acid, xanthurenic acid, indole-3-ethanol, and α-oxo-1H-indole-3-propanoic acid. Treatments significantly restored neuroprotective metabolites including kynurenic acid, xanthurenic acid, and serotonin. PICRUSt2 predicted tryptophan synthesis pathway-associated microbes (Oscillospira, Ruminococcus, Coprococcus). Treatments ameliorated motor deficits, oxidative stress, inflammation, and dopaminergic neuron death, correlating with gut microbiota modulation and accumulation of microbiota-derived tryptophan metabolites. Live bacteria showed superior antioxidant and neuroprotective efficacy compared to supernatant, likely due to sustained colonization and continuous metabolic activity. These findings suggest that targeting key tryptophan-metabolizing bacteria or their metabolites may be a potential PD therapy.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

Data Availability Statement

The raw data of 16S rRNA high-throughput sequencing was uploaded to the Sequence Read Archive (SRA) database of NCBI, accession number: PRJNA1345351 (https://www.ncbi.nlm.nih.gov/sra/PRJNA1345351, accessed on 15 July 2026), and the raw data of the untargeted metabolomics has been uploaded to the Metabolights database, accession number: MTBLS13169 (https://www.ebi.ac.uk/metabolights/MTBLS13169, accessed on 15 July 2026). The remaining data are available upon request from the corresponding author or the first author.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 5 keywords, 1 funder, 54 references.

Cite

This paper

Su, B., Meng, F., Lu, Y., Zhang, Y., Wang, T., Zhang, Y., Liu, J., & Lin, L. (2026). <i>Lactobacillus reuteri</i> DSM 17938 and Its Supernatant Ameliorate Parkinson's Disease in Association with Modulation of Gut Microbiota and Its Tryptophan Metabolism. Antioxidants (Basel, Switzerland), 15(7), 882. https://doi.org/10.3390/antiox15070882

BibTeX

@article{su2026lt,
author = {Su, Bin and Meng, Fanying and Lu, Yao and Zhang, Yunlong and Wang, Tingting and Zhang, Yuxin and Liu, Jiajia and Lin, Lianbing},
title = {{\<i\>Lactobacillus reuteri\</i\> DSM 17938 and Its Supernatant Ameliorate Parkinson's Disease in Association with Modulation of Gut Microbiota and Its Tryptophan Metabolism}},
journal = {Antioxidants (Basel, Switzerland)},
year = {2026},
month = jul,
volume = {15},
number = {7},
pages = {882},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {2076-3921},
doi = {10.3390/antiox15070882},
url = {https://doi.org/10.3390/antiox15070882},
pmid = {42510613},
pmcid = {PMC13406045}
}

RIS

TY - JOUR
AU - Su, Bin
AU - Meng, Fanying
AU - Lu, Yao
AU - Zhang, Yunlong
AU - Wang, Tingting
AU - Zhang, Yuxin
AU - Liu, Jiajia
AU - Lin, Lianbing
TI - <i>Lactobacillus reuteri</i> DSM 17938 and Its Supernatant Ameliorate Parkinson's Disease in Association with Modulation of Gut Microbiota and Its Tryptophan Metabolism
T2 - Antioxidants (Basel, Switzerland)
J2 - Antioxidants (Basel)
PY - 2026
DA - 2026/07/16
VL - 15
IS - 7
SP - 882
SN - 2076-3921
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/antiox15070882
UR - https://doi.org/10.3390/antiox15070882
LA - en
ER -

CSL-JSON

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