Noninvasive diffuse optical monitoring of cerebral blood flow and oxygenation responses to intermittent hypoxia in neonatal rats.
Overview
- University of Kentucky, Department of Biomedical Engineering, Lexington, Kentucky, United States
- Bioptics Technology LLC, Advanced Science & Technology Commercialization Center (ASTeCC), Lexington, Kentucky, United States
- University of Kentucky, Department of Internal Medicine, Lexington, Kentucky, United States
- University of Kentucky, Department of Neurosurgery, Lexington, Kentucky, United States
Abstract
Significance: Intermittent hypoxia (IH) is common in preterm neonates and can cause hypoxic–ischemic brain injury. Simultaneous monitoring of cerebral blood flow (CBF) and oxygenation is essential to detect oxygen delivery-extraction mismatches and guide intervention.
Aim: We aimed to adapt and test an innovative diffuse speckle contrast flow oximetry (DSCFO) system for continuous monitoring of cerebral hemodynamics during IH in neonatal rats, a model approximating human neonates.
Approach: Two compact laser diodes and a miniature CMOS camera were integrated into a fiber-free probe for continuous monitoring of changes in relative CBF (rCBF) and oxy- and deoxy-hemoglobin concentrations (Δ[HbO2] and Δ[Hb]) in 8-day-old neonatal rats. Sham rats (n=
Results: Sham rats maintained stable cerebral hemodynamics under normoxia, whereas IH rats exhibited pronounced periodic fluctuations during IH. Hypoxic episodes caused instantaneous decreases in rCBF and Δ[HbO2] and increases in Δ[Hb], whereas hyperoxic episodes reversed these effects, reducing hypoxic stress. However, the pronounced cerebral hemodynamic fluctuations during IH may still contribute to brain injury.
Conclusions: We demonstrate an affordable, noninvasive, wearable, fiber-free DSCFO system for continuous monitoring of rCBF, Δ[HbO2], and Δ[Hb] during IH in neonatal rats. The system captured hypoxia-induced cerebral deoxygenation and hyperoxia-driven recovery, revealing episode-dependent protective and disruptive mechanisms. Future work will correlate DSCFO findings with neurological and histological outcomes to guide IH interventions in large neonatal animal models and human infants.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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All codes and data supporting the findings of this study are available from the corresponding author upon reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 6 keywords, 11 MeSH terms, 1 funder, 66 references.
Cite
This paper
Safavi, P., Mohtasebi, M., Azimul Haque, C., Akbari, F., Liu, X., Yuan, Y., Chen, L., Chen, L., & Yu, G. (2026). Noninvasive diffuse optical monitoring of cerebral blood flow and oxygenation responses to intermittent hypoxia in neonatal rats. Journal of biomedical optics, 31(4), 047001. https://
BibTeX
@article{safavi2026nonin
author = {Safavi, Pegah and Mohtasebi, Mehrana and Azimul Haque, Chowdhury and Akbari, Faezeh and Liu, Xuhui and Yuan, Yiqi and Chen, Li and Chen, Lei and Yu, Guoqiang},
title = {{Noninvasive diffuse optical monitoring of cerebral blood flow and oxygenation responses to intermittent hypoxia in neonatal rats}},
journal = {Journal of biomedical optics},
year = {2026},
month = apr,
volume = {31},
number = {4},
pages = {047001},
publisher = {Society of Photo-Optical Instrumentation Engineers},
issn = {1083-3668},
doi = {10.1117/
url = {https://
pmid = {42007231},
pmcid = {PMC13086530}
}
RIS
TY - JOUR
AU - Safavi, Pegah
AU - Mohtasebi, Mehrana
AU - Azimul Haque, Chowdhury
AU - Akbari, Faezeh
AU - Liu, Xuhui
AU - Yuan, Yiqi
AU - Chen, Li
AU - Chen, Lei
AU - Yu, Guoqiang
TI - Noninvasive diffuse optical monitoring of cerebral blood flow and oxygenation responses to intermittent hypoxia in neonatal rats
T2 - Journal of biomedical optics
J2 - J Biomed Opt
PY - 2026
DA - 2026/
VL - 31
IS - 4
SP - 047001
SN - 1083-3668
PB - Society of Photo-Optical Instrumentation Engineers
DO - 10.1117/
UR - https://
LA - en
ER -
CSL-JSON
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