High mannose content of mesenchymal glioblastoma correlates with hydroxyl proton transfer-weighted (HPTw) MRI as noninvasive biomarker of tumor aggressiveness.
Overview
- Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Cellular Imaging Section and Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Hugo W. Moser Research Institute at Kennedy Krieger, Baltimore, MD, USA
- Department of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
- Department of Chemical & Biomolecular Engineering, The Johns Hopkins Whiting school of Engineering, Baltimore, MD, USA
Abstract
Glioblastoma (GBM) contains mesenchymal cancer stem cells that drive tumor aggressiveness and recurrence and exhibit aberrant glycosylation during proneural-to-mesenchymal
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 12 MeSH terms, 9 funders, 54 references.
Cite
This paper
Ghaemi, B., Lopez-Bertoni, H., Kuddannaya, S., Sall, S., Laterra, J., Liu, G., & Bulte, J. W. M. (2026). High mannose content of mesenchymal glioblastoma correlates with hydroxyl proton transfer-weighted (HPTw) MRI as noninvasive biomarker of tumor aggressiveness. Science advances, 12(20), eadz5324. https://
BibTeX
@article{ghaemi2026high,
author = {Ghaemi, Behnaz and Lopez-Bertoni, Hernando and Kuddannaya, Shreyas and Sall, Sophie and Laterra, John and Liu, Guanshu and Bulte, Jeff W M},
title = {{High mannose content of mesenchymal glioblastoma correlates with hydroxyl proton transfer-weighted (HPTw) MRI as noninvasive biomarker of tumor aggressiveness}},
journal = {Science advances},
year = {2026},
month = may,
volume = {12},
number = {20},
pages = {eadz5324},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/
url = {https://
pmid = {42127174},
pmcid = {PMC13170648}
}
RIS
TY - JOUR
AU - Ghaemi, Behnaz
AU - Lopez-Bertoni, Hernando
AU - Kuddannaya, Shreyas
AU - Sall, Sophie
AU - Laterra, John
AU - Liu, Guanshu
AU - Bulte, Jeff W M
TI - High mannose content of mesenchymal glioblastoma correlates with hydroxyl proton transfer-weighted (HPTw) MRI as noninvasive biomarker of tumor aggressiveness
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/
VL - 12
IS - 20
SP - eadz5324
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/
UR - https://
LA - en
ER -
CSL-JSON
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