Dissecting medial temporal lobe from diencephalic sub-volumes: The amnesia dichotomy revisited.
Overview
- Normandie Univ, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron, Caen, France
- Centre Hospitalier Universitaire de Caen, Caen, France
- Normandie Univ, UNIROUEN, CRFDP (EA 7475), Rouen, France
- Service de Biochimie, Centre Hospitalier Universitaire de Caen, Caen, France
- Normandie Univ, UNICAEN, PSL Université, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, Caen, France
- Institut Universitaire de France (IUF), Paris, France
Abstract
Severe episodic memory deficits have historically been categorized as diencephalic amnesia, like in Korsakoff’s Syndrome (KS), or as medial temporal lobe (MTL) amnesia, like in Alzheimer’s Disease (AD). However, recent research has highlighted that both MTL and thalamus contribute to episodic memory. We aimed to challenge the traditional distinction by assessing whether subregional volume loss in the MTL and diencephalon reflects the distinct amnesia profiles traditionally associated with KS and AD. This cross-sectional observational study includes 203 subjects, comprising 81 healthy control participants. Of the 122 patients, 42 had amnesia: 18 patients with KS and 24 patients with AD at a dementia stage (dAD); and 80 had mild cognitive disorders: 50 patients with severe alcohol use disorder (AUD) without KS and 30 patients with amnestic mild cognitive impairment (aMCI). High-resolution T1-weighted MRI was used to quantify MTL subregions (anterior/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
The paper's code and data availability statement is in the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.
Data
No dataset and no data link were found in the paper.
Data and Code Availability
The data used in this study are available from the corresponding author upon reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 11 authors, 6 keywords, 7 funders, 63 references.
Cite
This paper
Soussi, C., Chauveau, L., de Flores, R., Cabé, N., Laniepce, A., Coulbault, L., Boudehent, C., de la Sayette, V., Chételat, G., Segobin, S., & Pitel, A.-L. (2026). Dissecting medial temporal lobe from diencephalic sub-volumes: The amnesia dichotomy revisited. Imaging neuroscience (Cambridge, Mass.), 4, IMAG.a.1205. https://
BibTeX
@article{soussi2026disse
author = {Soussi, Célia and Chauveau, Léa and de Flores, Robin and Cabé, Nicolas and Laniepce, Alice and Coulbault, Laurent and Boudehent, Céline and de la Sayette, Vincent and Chételat, Gael and Segobin, Shailendra and Pitel, Anne-Lise},
title = {{Dissecting medial temporal lobe from diencephalic sub-volumes: The amnesia dichotomy revisited}},
journal = {Imaging neuroscience (Cambridge, Mass.)},
year = {2026},
month = apr,
volume = {4},
pages = {IMAG.a.1205},
publisher = {MIT Press},
issn = {2837-6056},
doi = {10.1162/
url = {https://
pmid = {41993142},
pmcid = {PMC13081738}
}
RIS
TY - JOUR
AU - Soussi, Célia
AU - Chauveau, Léa
AU - de Flores, Robin
AU - Cabé, Nicolas
AU - Laniepce, Alice
AU - Coulbault, Laurent
AU - Boudehent, Céline
AU - de la Sayette, Vincent
AU - Chételat, Gael
AU - Segobin, Shailendra
AU - Pitel, Anne-Lise
TI - Dissecting medial temporal lobe from diencephalic sub-volumes: The amnesia dichotomy revisited
T2 - Imaging neuroscience (Cambridge, Mass.)
J2 - Imaging Neurosci (Camb)
PY - 2026
DA - 2026/
VL - 4
SP - IMAG.a.1205
SN - 2837-6056
PB - MIT Press
DO - 10.1162/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1162/
"type": "article-journal",
"title": "Dissecting medial temporal lobe from diencephalic sub-volumes: The amnesia dichotomy revisited",
"container-title": "Imaging neuroscience (Cambridge, Mass.)",
"author": [
{
"family": "Soussi",
"given": "Célia"
},
{
"family": "Chauveau",
"given": "Léa"
},
{
"family": "de Flores",
"given": "Robin"
},
{
"family": "Cabé",
"given": "Nicolas"
},
{
"family": "Laniepce",
"given": "Alice"
},
{
"family": "Coulbault",
"given": "Laurent"
},
{
"family": "Boudehent",
"given": "Céline"
},
{
"family": "de la Sayette",
"given": "Vincent"
},
{
"family": "Chételat",
"given": "Gael"
},
{
"family": "Segobin",
"given": "Shailendra"
},
{
"family": "Pitel",
"given": "Anne-Lise"
}
],
"container-title-short":
"volume": "4",
"page": "IMAG.a.1205",
"DOI": "10.1162/
"PMID": "41993142",
"PMCID": "PMC13081738",
"ISSN": "2837-6056",
"publisher": "MIT Press",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
13
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1093/cercor/bhag069
- Diencephalic integrity explains aspects of hippocampal amnesia.Journal: Cerebral cortex (New York, N.Y. : 1991)In common: other condition, 9 references
- [2] doi:10.1371/journal.pone.0351431 [code]
- Revisiting the role of structural connectivity-based parcellation in thalamic nuclei segmentation: Benchmarking against recent state-of-the-art methods.Journal: PloS oneIn common: 5 references
- [3] doi:10.1007/s00429-026-03163-z [code]
- Toward reliable thalamic segmentation: an evaluation of automated methods for structural MRI.Journal: Brain structure & functionIn common: 4 references
- [4] doi:10.1002/hbm.70542 [code]
- The In Vivo Microstructural Profile of Human Hippocampal Subfield CA1 and Its Relation to Memory Performance.Journal: Human brain mappingIn common: 4 references
- [5] doi:10.1073/pnas.2603114123 [code]
- The human hippocampus can pattern separate memories by meaning.Journal: Proceedings of the National Academy of Sciences of the United States of AmericaIn common: 3 references
- [6] doi:10.1038/s44400-026-00101-y
- Functional network contributions to longitudinal tau spread in Posterior Cortical Atrophy.Journal: NPJ dementiaIn common: Alzheimer's / dementia, 2 references
- [7] doi:10.1002/alz.71571 [code]
- Vulnerability of anterior medial temporal lobe subregions to early tau-related neurodegeneration in Alzheimer's disease: Converging evidence from tau-PET and plasma p-tau217.Journal: Alzheimer's & dementia : the journal of the Alzheimer's AssociationIn common: Alzheimer's / dementia, other condition, 2 references
- [8] doi:10.3390/brainsci16050535
- Linking Auditory Brainstem Neural Stability to Parent-Reported Autistic Traits in School-Age Children.Journal: Brain sciencesIn common: 3 references
- [9] doi:10.1093/braincomms/fcag204 [code]
- Altered rhythmic and arrhythmic electroencephalographic activity during non-rapid eye movement sleep in amnestic mild cognitive impairment.Journal: Brain communicationsIn common: Alzheimer's / dementia, 2 references
- [10] doi:10.1016/j.ynirp.2026.100405
- White matter microstructure and motor function in amnestic mild cognitive impairment and Alzheimer's dementia.Journal: Neuroimage. ReportsIn common: Alzheimer's / dementia, 2 references
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.