OSCR

Integrated imaging and molecular profiling reveals APOE4-associated neurovascular and glial disruptions in young adult mice.

Overview

Authors: Yi Guan1, Chia Hsin Cheng1, Sonal Dinesh Khanna1, Catalina Fader1, Yolanda Ohene2,3, Jack A Wells4, Bang-Bon Koo1
ORCID iDs: Yolanda Ohene
  1. Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine,Boston, MA 02118 USA
  2. Division of Psychology, Communication and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester,Manchester, UK
  3. Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust, The University of Manchester,Manchester, UK
  4. UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London,London, UK
Institutions: Boston University (United States); University of Manchester (United Kingdom); University College London (United Kingdom)
Journal: Journal of neuroinflammation, volume 23, issue 1, article 262
Dates: received 24 February 2026; accepted 20 May 2026; published online 28 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03888-y · PMID 42210271 · PMCID PMC13430709 · OpenAlex W7162640213
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: genetics / omics (modality), structural MRI / diffusion (modality), mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Connectivity, fMRI & imaging, Physiology & signal measures
Keywords: APOE, Magnetic Resonance Imaging, Neurovascular Unit, Blood-Brain Barrier, Matrix Metalloproteinase-9
MeSH: Apolipoprotein E4*, Brain*, Neuroglia*, Animals, Astrocytes, Female, Magnetic Resonance Imaging, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: Department of Defense / Congressionally Directed Medical Research Programs (CDMRP) TERP (HT94252410934); Boston University Marion & Henri Gendron Fund
Citations: not cited yet (Europe PMC); 111 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

Tracing map

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Data

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Code and data availability statement

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  • it says that the data are available on request
  • it says that the code is available on request

Read it in the paper: doi.org/10.1186/s12974-026-03888-y.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 5 keywords, 11 MeSH terms, 2 funders, 108 references.

Cite

This paper

Guan, Y., Cheng, C. H., Khanna, S. D., Fader, C., Ohene, Y., Wells, J. A., & Koo, B.-B. (2026). Integrated imaging and molecular profiling reveals APOE4-associated neurovascular and glial disruptions in young adult mice. Journal of neuroinflammation, 23(1), 262. https://doi.org/10.1186/s12974-026-03888-y

BibTeX

@article{guan2026integrated,
author = {Guan, Yi and Cheng, Chia Hsin and Khanna, Sonal Dinesh and Fader, Catalina and Ohene, Yolanda and Wells, Jack A and Koo, Bang-Bon},
title = {{Integrated imaging and molecular profiling reveals APOE4-associated neurovascular and glial disruptions in young adult mice}},
journal = {Journal of neuroinflammation},
year = {2026},
month = may,
volume = {23},
number = {1},
pages = {262},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03888-y},
url = {https://doi.org/10.1186/s12974-026-03888-y},
pmid = {42210271},
pmcid = {PMC13430709}
}

RIS

TY - JOUR
AU - Guan, Yi
AU - Cheng, Chia Hsin
AU - Khanna, Sonal Dinesh
AU - Fader, Catalina
AU - Ohene, Yolanda
AU - Wells, Jack A
AU - Koo, Bang-Bon
TI - Integrated imaging and molecular profiling reveals APOE4-associated neurovascular and glial disruptions in young adult mice
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/05/28
VL - 23
IS - 1
SP - 262
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03888-y
UR - https://doi.org/10.1186/s12974-026-03888-y
LA - en
ER -

CSL-JSON

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"title": "Integrated imaging and molecular profiling reveals APOE4-associated neurovascular and glial disruptions in young adult mice",
"container-title": "Journal of neuroinflammation",
"author": [
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"family": "Guan",
"given": "Yi"
},
{
"family": "Cheng",
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{
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"container-title-short": "J Neuroinflammation",
"volume": "23",
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"page": "262",
"DOI": "10.1186/s12974-026-03888-y",
"PMID": "42210271",
"PMCID": "PMC13430709",
"ISSN": "1742-2094",
"publisher": "BMC",
"URL": "https://doi.org/10.1186/s12974-026-03888-y",
"language": "en",
"issued": {
"date-parts": [
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28
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]
}
}

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