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Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts.

Overview

Authors: Brooke D Conway Kleven1,2,3, Lung-Chang Chien1, Dana Surwill4, Michael L Alosco5,6,7,8,9, Jennifer V Wethe10, Yorghos Tripodis6,11, Charles H Adler12, Martha E Shenton13,14,15, Ofer Pasternak16,17, Douglas I Katz5,6,7, Elaine Peskind18,19, Laura J Balcer20, Inga K Koerte21,22,23,24, Jesse Mez5,6,7, Eric M Reiman25,26, Robert C Cantu6,7, Robert A Stern5,6,7,8,9, Henrik Zetterberg27,28,29,30,31,32,33, Charles Bernick34, Jeffrey L Cummings2,3
ORCID iDs: Brooke D Conway Kleven
34 affiliations
  1. Department of Epidemiology and Biostatistics, School of Public Health, University of Nevada Las Vegas, Las Vegas, NV USA
  2. Department of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, Las Vegas, NV USA
  3. Chambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada Las Vegas, Las Vegas, NV USA
  4. Department of Environmental and Global Health, School of Public Health, University of NevadaLas Vegas, Las Vegas, NV USA
  5. Department of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA USA
  6. Boston University Alzheimer’s Disease Research Center, Boston, MA USA
  7. BU CTE Center, Boston University, Boston, MA USA
  8. Department of Anatomy & Neurobiology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA USA
  9. Department of Neurology, Boston Medical Center, Boston, MA USA
  10. Department of Psychiatry and Psychology, Mayo Clinic School of Medicine and Science, Scottsdale, AZ USA
  11. Center for Health Data Science, Boston University School of Public Health, Boston, Massachusetts USA
  12. Department of Neurology, Mayo Clinic School of Medicine and Science, Scottsdale, AZ USA
  13. Department of Psychiatry and Radiology, Harvard Medical School, Boston, MA USA
  14. Brigham and Women’s Hospital and Baker Children’s Center, Boston, MA USA
  15. Massachusetts General Hospital, Boston, MA USA
  16. Department of Psychiatry, Mass General Brigham, Harvard Medical School, Boston, MA USA
  17. Department of Radiology, Mass General Brigham, Harvard Medical School, Boston, MA USA
  18. Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA USA
  19. VA Puget Sound Health Care System, Seattle, WA USA
  20. Department of Neurology, Grossman School of Medicine, New York University, New York, NY USA
  21. Department of Child and Adolescent Psychiatry, Psychosomatic and Psychotherapy, cBRAIN, Ludwig-Maximilians-Universität (LMU), Munich, Germany
  22. German Center for Child and Adolescent Health (DZKJ), Partner site Munich, Munich, Germany
  23. Psychiatry Neuroimaging Laboratory, Psychiatry Department, Mass General Brigham Academic Medical Centers, Boston, MA USA
  24. Harvard Medical School, Boston, MA USA
  25. Banner Alzheimer’s Institute, Phoenix, AZ USA
  26. Department of Psychiatry, University of Arizona College of Medicine – Phoenix, Phoenix, AZ USA
  27. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden
  28. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden
  29. Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI USA
  30. Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI USA
  31. Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK
  32. UK Dementia Research Institute at UCL, London, UK
  33. Centre for Brain Research, Indian Institute of Science, Bangalore, India
  34. Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV USA
Institutions: University of Nevada, Las Vegas (United States); Boston University (United States); Boston Medical Center (United States); Mayo Clinic in Arizona (United States); Mayo Clinic (United States); Brigham and Women's Hospital (United States); Harvard University (United States); Massachusetts General Hospital (United States); Mass General Brigham (United States); University of Washington (United States); VA Puget Sound Health Care System (United States); New York University (United States); Ludwig-Maximilians-Universität München (Germany); Banner Alzheimer’s Institute; University of Arizona College of Medicine- Phoenix (United States); University of Wisconsin–Madison (United States); Sahlgrenska University Hospital (Sweden); UK Dementia Research Institute (United Kingdom); National Hospital for Neurology and Neurosurgery (United Kingdom); UCL Queen Square Institute of Neurology (United Kingdom); University College London (United Kingdom); Indian Institute of Science Bangalore (India); University of Gothenburg (Sweden); Cleveland Clinic (United States); Lou Ruvo Brain Institute (United States)
Journal: Alzheimer's research & therapy, volume 18, issue 1, article 189
Dates: received 11 April 2026; accepted 4 June 2026; published online 13 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s13195-026-02110-8 · PMID 42288852 · PMCID PMC13495526 · OpenAlex W7164515092
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: structural MRI / diffusion (modality), other (modality), human (organism), other condition (population), Alzheimer's / dementia (population), traumatic brain injury (population), clinical / translational (subfield)
Methods: Statistics, Machine learning
Keywords: Chronic traumatic encephalopathy, Traumatic encephalopathy syndrome, Repetitive head impacts, Blood biomarkers, Neuroimaging, Neurodegeneration
MeSH: Athletes*, Brain*, Chronic Traumatic Encephalopathy*, Cognition*, Adult, Athletic Injuries, Biomarkers, Cohort Studies, Football, Humans, Magnetic Resonance Imaging, Male, Neurofilament Proteins, Neuroimaging, Neuropsychological Tests, tau Proteins, Young Adult (* major topic)
Topic: Traumatic Brain Injury Research (Epidemiology, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 38 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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  • it says that the data are available on request
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Read it in the paper: doi.org/10.1186/s13195-026-02110-8.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 6 keywords, 17 MeSH terms, 34 references.

Cite

This paper

Conway Kleven, B. D., Chien, L.-C., Surwill, D., Alosco, M. L., Wethe, J. V., Tripodis, Y., Adler, C. H., Shenton, M. E., Pasternak, O., Katz, D. I., Peskind, E., Balcer, L. J., Koerte, I. K., Mez, J., Reiman, E. M., Cantu, R. C., Stern, R. A., Zetterberg, H., Bernick, C., & Cummings, J. L. (2026). Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts. Alzheimer's research & therapy, 18(1), 189. https://doi.org/10.1186/s13195-026-02110-8

BibTeX

@article{conwaykleven2026cognitive,
author = {Conway Kleven, Brooke D and Chien, Lung-Chang and Surwill, Dana and Alosco, Michael L and Wethe, Jennifer V and Tripodis, Yorghos and Adler, Charles H and Shenton, Martha E and Pasternak, Ofer and Katz, Douglas I and Peskind, Elaine and Balcer, Laura J and Koerte, Inga K and Mez, Jesse and Reiman, Eric M and Cantu, Robert C and Stern, Robert A and Zetterberg, Henrik and Bernick, Charles and Cummings, Jeffrey L},
title = {{Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts}},
journal = {Alzheimer's research \& therapy},
year = {2026},
month = jun,
volume = {18},
number = {1},
pages = {189},
publisher = {BMC},
issn = {1758-9193},
doi = {10.1186/s13195-026-02110-8},
url = {https://doi.org/10.1186/s13195-026-02110-8},
pmid = {42288852},
pmcid = {PMC13495526}
}

RIS

TY - JOUR
AU - Conway Kleven, Brooke D
AU - Chien, Lung-Chang
AU - Surwill, Dana
AU - Alosco, Michael L
AU - Wethe, Jennifer V
AU - Tripodis, Yorghos
AU - Adler, Charles H
AU - Shenton, Martha E
AU - Pasternak, Ofer
AU - Katz, Douglas I
AU - Peskind, Elaine
AU - Balcer, Laura J
AU - Koerte, Inga K
AU - Mez, Jesse
AU - Reiman, Eric M
AU - Cantu, Robert C
AU - Stern, Robert A
AU - Zetterberg, Henrik
AU - Bernick, Charles
AU - Cummings, Jeffrey L
TI - Cognitive, biomarker, and neuroimaging indices associated with traumatic encephalopathy syndrome across two independent athlete cohorts
T2 - Alzheimer's research & therapy
J2 - Alzheimers Res Ther
PY - 2026
DA - 2026/06/13
VL - 18
IS - 1
SP - 189
SN - 1758-9193
PB - BMC
DO - 10.1186/s13195-026-02110-8
UR - https://doi.org/10.1186/s13195-026-02110-8
LA - en
ER -

CSL-JSON

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